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Benitez-King G.,Laboratorio Of Neurofarmacologia | Valdes-Tovar M.,Laboratorio Of Neurofarmacologia | Trueta C.,Instituto Nacional Of Psiquiatria Ramon Of La Fuente Muniz Inprfm | Galvan-Arrieta T.,Laboratorio Of Neurofarmacologia | And 4 more authors.
Molecular and Cellular Neuroscience | Year: 2016

Schizophrenia (SZ) and Bipolar Disorder (BD) are highly inheritable chronic mental disorders with a worldwide prevalence of around 1%. Despite that many efforts had been made to characterize biomarkers in order to allow for biological testing for their diagnoses, these disorders are currently detected and classified only by clinical appraisal based on the Diagnostic and Statistical Manual of Mental Disorders. Olfactory neuroepithelium-derived neuronal precursors have been recently proposed as a model for biomarker characterization. Because of their peripheral localization, they are amenable to collection and suitable for being cultured and propagated in vitro. Olfactory neuroepithelial cells can be obtained by a non-invasive brush-exfoliation technique from neuropsychiatric patients and healthy subjects. Neuronal precursors isolated from these samples undergo in vitro the cytoskeletal reorganization inherent to the neurodevelopment process which has been described as one important feature in the etiology of both diseases. In this paper, we will review the current knowledge on microtubular organization in olfactory neurons of patients with SZ and with BD that may constitute specific cytoskeletal endophenotypes and their relation with alterations in L-type voltage-activated Ca2+ currents. Finally, the potential usefulness of neuronal precursors for pharmacological screening will be discussed. © 2016 Elsevier Inc. Source


Marjan Lopez De La Parra M.D.P.,Instituto Nacional Of Psiquiatria Ramon Of La Fuente Muniz Inprfm | Cabrera D.M.,Servicios Clinicos | Suarez M.A.M.,Servicio de Hospitalizacion | Anzaldua A.D.,INPRFM | Sotres J.F.C.,INPRFM
Salud Mental | Year: 2014

Objective: To determine which clinical factors predict disability and poor quality of life in patients with generalized anxiety disorder. Methodology: This was a descriptive cross-sectional study. Data were analyzed using frequencies, percentages, mean. A linear regression analysis was used to determine how demographic factors predict clinical disability and poor quality of life. Results: We found that the presence of a family history of anxiety disorders, as well as higher scores on the Hamilton Depression Scale, predict a lower quality of life; unlike an older age which predicts a higher quality of life in these patients. Higher levels of disability were associated with males, a younger age, comorbid Axis II disorders, the presence of a family history of anxiety disorders, and higher scores on the Hamilton Depression Scale. Conclusions: Depressive symptoms and a family history of anxiety are associated with a poor quality of life. Knowing which factors predict the quality of life and disability in patients may guide us towards a more comprehensive diagnosis and treatment approach. This means will not just treat symptoms, but will seek patients' functional recovery, which leads in turn to a better quality of life. Source


Molina-Lopez A.,Instituto Nacional Of Psiquiatria Ramon Of La Fuente Muniz Inprfm | Lopez-Pedraza M.C.,Programa de Voluntad Anticipada | Morales-Gordillo N.,Servicio de Psicofarmacologia del Desarrollo | Ontiveros Uribe M.P.,Subdireccion de Hospital y Atencion Psiquiatrica Continua | Fresan-Orellana A.,INPRFM
Salud Mental | Year: 2014

Background The demand for Psychiatry Emergency Services (PES) has increased during the last years. There is little knowledge about the activity indicators of PES at Mexican psychiatric hospitals. It is necessary to study the activities of these PES, especially the ones which work through voluntary care and with no emergency severity assessment procedure (Triage) before consultation. Objective To describe and compare the activity indicators of a PES within a psychiatric hospital in Mexico City during five years. This hospital offered only voluntary care with no Triage procedure. Material and method The database of all registered PES visits from January 1st, 2004, to December 31th, 2008, was analysed. We determined the overall number of consultations and relative frequencies by trimester, semester, year and five years. After this, indicators were broken down using service variables and psychiatric diagnosis according to the ICD-10; they were then compared with each other. Results A total of n=41 058 consultations were attended during five years, showing an enhancement of 14.8% in the overall PES activity. We observed a significant enhancement of patients' proportion with no compliance to outpatient treatment as well as more night schedule visitations, while references and admission proportions decreased more than 4%. This suggests a "snow ball-like" progressive enhancement of frequent patients of PES with non-urgent conditions. We did not find any changes in psychiatric diagnosis proportion during the study, but there was a significant 9.69% increase in the overall activity of the first semester compared with the second one. Discussion Voluntary care with no Triage procedure tends to enhance the influx of frequent patients with non-urgent conditions, leading to PES overcrowding and disfavoring urgent conditions, specially during the first semester of each year. Source


Lozano-Verduzco I.,National Pedagogical University of Mexico | Marin-Navarrete R.,Instituto Nacional Of Psiquiatria Ramon Of La Fuente Muniz Inprfm | Marin-Navarrete R.,Ibero-American University of Mexico | Romero-Mendoza M.,Instituto Nacional Of Psiquiatria Ramon Of La Fuente Muniz Inprfm | Tena-Suck A.,Ibero-American University of Mexico
American Journal of Men's Health | Year: 2015

Fundamental elements of hegemonic masculinity such as power and violence are analyzed through characteristics of 12-step programs and philosophy immersed in Mutual-Aid Residential Centers for Addiction Treatment (CRAMAAs). CRAMAAs are a culturally specific form of substance abuse treatment in Mexico that are characterized by control and violence. Fifteen interviews were carried out with men of varied sociodemographic characteristics, and who resided in at least two of these centers. Results identify that power is expressed through drug abuse and leads them to subsequent biopsychosocial degradation. Residency in CRAMAAs is motivated by women, but men do not seek the residency and are usually admitted unwillingly. Power through violence is carried out inside CRAMAAs where men are victims of abuse. From a 12-step philosophy, this violence is believed to lead them to a path of recovery but instead produces feelings of anger and frustration. The implications of these centers on Mexican public health are discussed. © 2015, © The Author(s) 2015. Source


Alvarez-Salas E.,Instituto Nacional Of Psiquiatria Ramon Of La Fuente Muniz Inprfm | Aceves C.,Instituto Nacional Of Psiquiatria Ramon Of La Fuente | Anguiano B.,Instituto Nacional Of Psiquiatria Ramon Of La Fuente | Uribe R.M.,National Autonomous University of Mexico | And 3 more authors.
Endocrinology | Year: 2012

TRH synthesized in hypothalamic paraventricular nucleus (PVN) regulates thyroid axis function and is also implicated in anorexigenic effects. Under energy deficit, animals present decreased PVNTRH expression and release, low TSH levels, and increased appetite. Dehydration-induced anorexia (DIA) model allows insight into underlying mechanisms of feeding regulation. Animals drinking a 2.5% NaCl solution for 7 d present body weight reduction; despite their negative energy balance, they avoid food and have increased PVN TRH expression and TSH serum levels. These findings support an inhibiting role of PVN TRH in feeding control. We compared TRH expression by in situ hybridization in PVN subdivisions of 7-d dehydrated male rats to those of a pair-fed group (forced food-restricted) with similar metabolic changes than DIA, but motivated to eat, and to controls.We measured peripheral deiodinase activities, and expression and activity of medial basal hypothalamic type 2 deiodinase and pyroglutamyl-aminopeptidase II, to understand their regulating role in PVNTRH changes between food restriction and anorexia. TRH mRNA levels increased in anterior (aPVN) and medial-caudal subdivisions in DIA rats, whereas it decreased in medial PVN in both experimental groups. We confirmed the nonhypophysiotropic nature of aPVN TRHergic cells by injecting ip fluorogold tracer. Findings support a subspecialization of TRHergic hypophysiotrophic cells that responded differently between anorexic and food-restricted animals; also, that aPVN TRH participates in food intake regulation. Increased type 2 deiodinase activity seemed responsible for low medial PVN TRH synthesis, whereas increased medial basal hypothalamic pyroglutamyl-aminopeptidase II activity inDIA rats might counteract their high TRH release. Copyright © 2012 by The Endocrine Society. Source

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