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Noda M.F.,Instituto Nacional Of Oncologia Y Radiobiologia
Revista Cubana de Medicina | Year: 2012

The microRNAs (miRNAs) are a type of non-coding RNAs that act as gene expression regulators. The sequences of many of them are preserved into unrelated organisms, all of which suggests that these molecules do participate in essential biological processes. The miRNA expressions are often altered in many types of human cancers and they are critical to carcinogenesis, since they work as tumor suppressor genes or as oncogenes. Recent studies have proved that miRNAs are very associated to the cancer progression including the growth of tumor, the tumoral differentiation, the adhesion, the apoptosis, the invasion and the formation of metastasis. This literature review presented the basic and translational research carried out in the last decade, a period that may be called "the revolution of miRNAs" in the molecular oncology. It covered the characteristics, the biogenesis and processing and the functions of miRNAs as well as the mechanisms that modify their expression in cancer. The miRNAs have aroused great interest because of their potential applications in the field of medicine; therefore, the future perspectives in the diagnosis, prognosis and treatment of cancer by using miRNAs were also addressed. Source


Ferbeyre-Binelfa L.,Instituto Nacional Of Oncologia Y Radiobiologia
Cirugia y Cirujanos | Year: 2010

Background: Latissimus dorsi flap was the first myocutaneous flap reported in the literature. Tansini published in 1906 his experience in breast reconstruction. Quillen in 1978 used it as a pedicled flap for the first time in the head and neck region. Our study presents how to use this technique in head and neck reconstruction. The purpose of this report is to show functional and aesthetic results and to report complications with our patients. Methods: We performed a retrospective review of the clinical charts of 30 consecutive patients with various cancers admitted to the Institute of Oncology in La Habana, Cuba between September 1998 and August 2002 and who underwent latissimus dorsi flap reconstruction. We focus our report on functional and aesthetic results and postoperative complications Results: Tissue coverage was provided for eight large defects of the skin and soft tissues of the neck, ten hypopharyngoesophageal resections, eight oral cavity resections including two with full thickness loss of the cheek, two large parotid skin defects and two orbitomaxillary defects. Complete flap necrosis was present in three cases, all with hypopharyngoesophageal reconstructions. Partial necrosis occurred in two cases. Conclusions: The latissimus dorsi flap is a reliable method in head and neck reconstruction. Because of its exposed pedicle it is more likely to necrose after local infection and fistula in hypopharyngoesophageal reconstructions. Source


Wals L.S.,Instituto Nacional Of Oncologia Y Radiobiologia
Revista Cubana de Cirugia | Year: 2013

Breast cancer represents the highest incidence rate of this disease and the second cause of death in the female sex. Mastectomy is preformed as a result of surgical treatment. It causes patient's worry about undergoing reconstructive surgery. In this work, three cases of women who underwent mastectomies because they were suffering from cancer and benign diseases of aggressive behavior were presented. These women were treated in the Reconstructive Surgery Service of the National Institute of Oncology and Radiobiology from March 2010 to March 2012. Mammary reconstruction was performed in each patient, applying the most convenient surgical technique, according to the case. Surgical techniques such as tissular expansion, the latissimus dorsi myocutaneous flap, and the TRAM (transverse rectus abdominis myocutaneous) were used. All cases could be reconstructed, achieving good aesthetic results. The advantages of mammary reconstruction and the validity of myocutaneous flaps were demonstrated. Source


Moro-Soria A.,Instituto Nacional Of Oncologia Y Radiobiologia
Biotecnologia Aplicada | Year: 2014

Malignant tumors rank as the first cause of death mortality and potentially lost years of life in Cuba and many other countries where millions of people die each year because of cancer. Therefore, the diagnosis and treatment of cancer is a health issue worldwide. Malignant tumors are traditionally classified and treated according to clinical and pathological variables which are currently insufficient to reflect each patient's molecular features. Consequently, there is a need to find new individual biomarkers and therapeutic targets that could complement current clinical-pathological variables and become a guide for diagnosis, prognosis and treatment. Advances in understanding the biology of cancer as well as the development of more powerful gene analysis tools create new clinical perspectives to find such biomarkers and targets. MicroRNAs (miRNAs) belong to a class of non-coding RNA with post-transcription regulation of gene expression. Their expression is aberrant in cancer where they could function either as oncogenes or tumor suppressors, being used as diagnostic, prognostic or predictive biomarkers and therapeutic targets. Since, research on miRNA is a key issue for oncologists and researchers, in this review we provide a description of their biogenesis, mechanism of action and recent findings, supporting their use in cancer, either as biomarkers or therapeutic targets. Source


Moro-Soria A.,Instituto Nacional Of Oncologia Y Radiobiologia
Biotecnologia Aplicada | Year: 2014

Malignant tumors rank as the first cause of death mortality and potentially lost years of life in Cuba and many other countries where millions of people die each year because of cancer. Therefore, the diagnosis and treatment of cancer is a health issue worldwide. Malignant tumors are traditionally classified and treated according to clinical and pathological variables which are currently insufficient to reflect each patient's molecular features. Consequently, there is a need to find new individual biomarkers and therapeutic targets that could complement current clinical-pathological variables and become a guide for diagnosis, prognosis and treatment. Advances in understanding the biology of cancer as well as the development of more powerful gene analysis tools create new clinical perspectives to find such biomarkers and targets. MicroRNAs (miRNAs) belong to a class of non-coding RNA with post-transcription regulation of gene expression. Their expression is aberrant in cancer where they could function either as oncogenes or tumor suppressors, being used as diagnostic, prognostic or predictive biomarkers and therapeutic targets. Since, research on miRNA is a key issue for oncologists and researchers, in this review we provide a description of their biogenesis, mechanism of action and recent findings, supporting their use in cancer, either as biomarkers or therapeutic targets. Source

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