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Rios Hernandez M.L.A.,Instituto Nacional Of Oncologia Y Radiobiologia | Menendez M.H.,Instituto Nacional Of Oncologia Y Radiobiologia | Noda M.F.,Instituto Nacional Of Oncologia Y Radiobiologia
Revista Cubana de Obstetricia y Ginecologia | Year: 2016

Introduction: conventional risk factors cannot explain all cases of sporadic breast cancer. Infections caused by the mouse mammary tumor virus, Epstein-Barr virus and human papillomavirus have been suggested to be potential risk factors for this condition. Objective: to update the information on the role of some viral infections in the development of breast cancer. Methods: a review was conducted of papers about the subject published in several databases (PubMed, Medline, BioMed Central and SciELO). Conclusions: despite the fact that criteria on the subject are controversial, some results suggest that the action of these viruses may contribute to the development of malignant breast disease. © 2016, Editorial Ciencias Medicas. All rights reserved.


Rosa-Diaz J.,Clinica Central Cira Garcia | Navarrete-Zuazo V.,Clinica Central Cira Garcia | Diaz-Mendiondo M.,Instituto Nacional Of Oncologia Y Radiobiologia
Revista Mexicana de Anestesiologia | Year: 2014

Postoperative pain does not serve a useful function and the risk of not treating it is an increase in postoperative morbidity and mortality. Its successful treatment is one of the most important challenges remaining in the surgical field. Postoperative pain is associated with a noxious stimulus that triggers the pain mechanism by the nociceptive receptors activation. In its production concur all those neurotransmitters and neuromodulators of the conduction pathways and integrators of pain centers and, if pain persists, may evolve to become chronic. In order to solve this complex problem, numerous techniques and various drugs have been investigated. The primary goal of sound management of drugs, is to optimize the efficacy and minimize toxicity. The unimodal analgesia is insufficient, so multimodal therapies are currently recommended, in which different routes of administration and different analgesic or anesthetic drugs are combined, resulting in a synergistic effect which increases the analgesic potency, decreases doses and reduces the possibility of occurrence of side effects. The aim of this review is to present the main mechanisms of development of postoperative pain and relate its control to the mechanism of action of the major groups of analgesic drugs used and to address the preventive use of multimodal analgesia.


Guerra Mesa J.L.,Instituto Nacional Of Oncologia Y Radiobiologia | Silveira Pablos M.,Instituto Nacional Of Oncologia Y Radiobiologia
Revista Cubana de Cirugia | Year: 2016

Acute colonic pseudo-obstruction, also known as Ogilvie’s syndrome, refers to an acute massive colonic dilatation with combined symptoms and signs of colonic obstruction in the absence of mechanical obstruction. Although it is a well-known clinical entity, in many aspects it remains poorly understood and continues to challenge physicians and surgeons alike. Early recognition and appropriate management are critical to minimize morbidity and mortality. The case is presented of a female patient bearer of a post laparotomic evisceration caused by an acute massive colonic dilatation of Ogilvie’s syndrome, who was submitted to urgent surgical treatment with full recovery. This paper is aimed at presenting an unusual way of onset of Ogilvie’s syndromeand the review of the specialized literature. © 2016, Editorial Ciencias Medicas. All rights reserved.


Wals L.S.,Instituto Nacional Of Oncologia Y Radiobiologia
Revista Cubana de Cirugia | Year: 2013

Breast cancer represents the highest incidence rate of this disease and the second cause of death in the female sex. Mastectomy is preformed as a result of surgical treatment. It causes patient's worry about undergoing reconstructive surgery. In this work, three cases of women who underwent mastectomies because they were suffering from cancer and benign diseases of aggressive behavior were presented. These women were treated in the Reconstructive Surgery Service of the National Institute of Oncology and Radiobiology from March 2010 to March 2012. Mammary reconstruction was performed in each patient, applying the most convenient surgical technique, according to the case. Surgical techniques such as tissular expansion, the latissimus dorsi myocutaneous flap, and the TRAM (transverse rectus abdominis myocutaneous) were used. All cases could be reconstructed, achieving good aesthetic results. The advantages of mammary reconstruction and the validity of myocutaneous flaps were demonstrated.


Noda M.F.,Instituto Nacional Of Oncologia Y Radiobiologia
Revista Cubana de Medicina | Year: 2012

The microRNAs (miRNAs) are a type of non-coding RNAs that act as gene expression regulators. The sequences of many of them are preserved into unrelated organisms, all of which suggests that these molecules do participate in essential biological processes. The miRNA expressions are often altered in many types of human cancers and they are critical to carcinogenesis, since they work as tumor suppressor genes or as oncogenes. Recent studies have proved that miRNAs are very associated to the cancer progression including the growth of tumor, the tumoral differentiation, the adhesion, the apoptosis, the invasion and the formation of metastasis. This literature review presented the basic and translational research carried out in the last decade, a period that may be called "the revolution of miRNAs" in the molecular oncology. It covered the characteristics, the biogenesis and processing and the functions of miRNAs as well as the mechanisms that modify their expression in cancer. The miRNAs have aroused great interest because of their potential applications in the field of medicine; therefore, the future perspectives in the diagnosis, prognosis and treatment of cancer by using miRNAs were also addressed.


Ferbeyre-Binelfa L.,Instituto Nacional Of Oncologia Y Radiobiologia
Cirugia y Cirujanos | Year: 2010

Background: Latissimus dorsi flap was the first myocutaneous flap reported in the literature. Tansini published in 1906 his experience in breast reconstruction. Quillen in 1978 used it as a pedicled flap for the first time in the head and neck region. Our study presents how to use this technique in head and neck reconstruction. The purpose of this report is to show functional and aesthetic results and to report complications with our patients. Methods: We performed a retrospective review of the clinical charts of 30 consecutive patients with various cancers admitted to the Institute of Oncology in La Habana, Cuba between September 1998 and August 2002 and who underwent latissimus dorsi flap reconstruction. We focus our report on functional and aesthetic results and postoperative complications Results: Tissue coverage was provided for eight large defects of the skin and soft tissues of the neck, ten hypopharyngoesophageal resections, eight oral cavity resections including two with full thickness loss of the cheek, two large parotid skin defects and two orbitomaxillary defects. Complete flap necrosis was present in three cases, all with hypopharyngoesophageal reconstructions. Partial necrosis occurred in two cases. Conclusions: The latissimus dorsi flap is a reliable method in head and neck reconstruction. Because of its exposed pedicle it is more likely to necrose after local infection and fistula in hypopharyngoesophageal reconstructions.


Moro-Soria A.,Instituto Nacional Of Oncologia Y Radiobiologia
Biotecnologia Aplicada | Year: 2014

Malignant tumors rank as the first cause of death mortality and potentially lost years of life in Cuba and many other countries where millions of people die each year because of cancer. Therefore, the diagnosis and treatment of cancer is a health issue worldwide. Malignant tumors are traditionally classified and treated according to clinical and pathological variables which are currently insufficient to reflect each patient's molecular features. Consequently, there is a need to find new individual biomarkers and therapeutic targets that could complement current clinical-pathological variables and become a guide for diagnosis, prognosis and treatment. Advances in understanding the biology of cancer as well as the development of more powerful gene analysis tools create new clinical perspectives to find such biomarkers and targets. MicroRNAs (miRNAs) belong to a class of non-coding RNA with post-transcription regulation of gene expression. Their expression is aberrant in cancer where they could function either as oncogenes or tumor suppressors, being used as diagnostic, prognostic or predictive biomarkers and therapeutic targets. Since, research on miRNA is a key issue for oncologists and researchers, in this review we provide a description of their biogenesis, mechanism of action and recent findings, supporting their use in cancer, either as biomarkers or therapeutic targets.


Moro-Soria A.,Instituto Nacional Of Oncologia Y Radiobiologia
Biotecnologia Aplicada | Year: 2014

Malignant tumors rank as the first cause of death mortality and potentially lost years of life in Cuba and many other countries where millions of people die each year because of cancer. Therefore, the diagnosis and treatment of cancer is a health issue worldwide. Malignant tumors are traditionally classified and treated according to clinical and pathological variables which are currently insufficient to reflect each patient's molecular features. Consequently, there is a need to find new individual biomarkers and therapeutic targets that could complement current clinical-pathological variables and become a guide for diagnosis, prognosis and treatment. Advances in understanding the biology of cancer as well as the development of more powerful gene analysis tools create new clinical perspectives to find such biomarkers and targets. MicroRNAs (miRNAs) belong to a class of non-coding RNA with post-transcription regulation of gene expression. Their expression is aberrant in cancer where they could function either as oncogenes or tumor suppressors, being used as diagnostic, prognostic or predictive biomarkers and therapeutic targets. Since, research on miRNA is a key issue for oncologists and researchers, in this review we provide a description of their biogenesis, mechanism of action and recent findings, supporting their use in cancer, either as biomarkers or therapeutic targets.


Martin Alfonso C.L.A.,Escuela Nacional de Salud Publica | Grau Abalo C.J.A.,Instituto Nacional Of Oncologia Y Radiobiologia | Espinosa Brito C.A.D.,Hospital Gustavo Aldereguia Lima
Revista Cubana de Salud Publica | Year: 2014

Difficulties in monitoring the medical indications for chronically-ill patients, make thestudy of adherenceto treatmentan important and update research line This paper was aimed at presenting a conceptual framework to substantiate from the theoretical point of view, the understanding of the concept of adherence to treatment of chronic diseases as opposed to the use of other terms in research and medical practice. For the current state of researchon the subject, the available databases on telematics Health Network in Cuba, from 2003 to 2007 were reviewed. A proposal was submitted which allows enriching the actions to encourage adherence related to a comprehensive care system of chronically-ill patients. The conceptual framework may represent a referent for the study, evaluation and improvement of adherence to medical treatment in those patients.


Ferbeyre-Binelfa L.,Instituto Nacional Of Oncologia Y Radiobiologia
Cirugia y cirujanos | Year: 2010

Latissimus dorsi flap was the first myocutaneous flap reported in the literature. Tansini published in 1906 his experience in breast reconstruction. Quillen in 1978 used it as a pedicled flap for the first time in the head and neck region. Our study presents how to use this technique in head and neck reconstructive surgery. The purpose of this report is to show functional and aesthetic results and to report complications with our patients. We performed a retrospective review of the clinical charts of 30 consecutive patients with various cancers admitted to the Institute of Oncology in Havana, Cuba between September 1998 and August 2002 and who underwent latissimus dorsi myocutaneous flap (LDMF) reconstruction. We focus our report on functional and aesthetic results and postoperative complications. Tissue coverage was provided for eight large defects of the skin and soft tissues of the neck, ten hypopharyngoesophageal resections, eight oral cavity resections including two with full thickness loss of the cheek, two large parotid skin defects and two orbitomaxillary defects. Complete flap necrosis was present in three cases, all with hypopharyngoesophageal reconstructions. Partial necrosis occurred in two cases. LDMF is a reliable method in head and neck reconstruction. Because of its exposed pedicle it is more likely to necrose after local infection and fistula in hypopharyngoesophageal reconstructions.

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