Caracas, Venezuela
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Dos Santos Cerda M.F.,Instituto Nacional Of Nutricion | Ortega C.A.O.,Direccion de Estudios Nutricionales | Rivas J.B.,Simon Bolivar University of Venezuela
Revista Espanola de Nutricion Comunitaria | Year: 2014

Background: Screen time or been in contact with television or electronics are part of the obesogenic environment which includes factors such as the advertising of unhealthy foods, consumption of fast food and sedentarism. This study evaluates the association between screen time, food consumption, nutritional status and physical activity in Venezuelan children. Methods: Descriptive and transversal study with a non probabilistic sample of 8,073 subjects 7-14 years attending schools in Venezuela. Data were analyzed using descriptive statistics comparison between variables and simple logistic regression between the screen time and associated variables. Results:86% of children and adolescents spend 2 hours or less in front of screens. The more screen time is associated with increased consumption high energy density foods (e.x. cookies), higher body mass index and fat area and fewer hours of physical activity (p < 0.05). Conclusions: The screen time that children invest is a predictor of overweight and obesity in children studied. We need to design and apply public policies to control this problem and reduce the risk of chronic noncommunicable diseases in adulthood.


Marin-Hernandez A.,Instituto Nacional Of Cardiologia | Gallardo-Perez J.C.,Instituto Nacional Of Cardiologia | Lopez-Ramirez S.Y.,Instituto Nacional Of Cardiologia | Garcia-Garcia J.D.,Instituto Nacional Of Cardiologia | And 10 more authors.
Archives of Toxicology | Year: 2012

The copper-based drug Casiopeina II-gly (CasII-gly) shows potent antineoplastic eVect and diminishes mitochondrial metabolism on several human and rodent malignant tumors. To elucidate whether CasII-gly also aVects glycolysis, (a) the Xux through the complete pathway and the initial segment and (b) the activities of several glycolytic enzymes of AS-30D hepatocarcinoma cells were determined. CasII-gly (IC 50 = 0.74-6.7 μM) was more eVective to inhibit 24-72 h growth of several human carcinomas than 3-bromopyruvate (3BrPyr) (IC 50 = 45- 100 μM) with no apparent eVect on normal human-proliferating lymphocytes and HUVECs. In short-term 60-min experiments, CasII-gly increased tumor cell lactate production and glycogen breakdown. CasII-gly was 1.3-21 times more potent than 3BrPyr and cisplatin to inhibit tumor HK. As CasII-gly inhibited the soluble and mitochondrial HK activities and the Xux through the HK-TPI glycolytic segment, whereas PFK-1, GAPDH, PGK, PYK activities and HPI-TPI segment Xux were not aVected, the data suggested glycogenolysis activation induced by HK inhibition. Accordingly, glycogen-depleted as well as oligomycintreated cancer cells became more sensitive to CasII-gly. The inhibition time-course of HK by CasII-gly was slower than that of OxPhos in AS-30D cells, indicating that glycolytic toxicity was secondary to mitochondria, the primary CasII-gly target. In long-term 24-h experiments with HeLa cells, 5 μM CasII-gly inhibited OxPhos (80%), glycolysis (40%), and HK (42%). The present data indicated that CasII-gly is an eVective multisite anticancer drug simultaneously targeting mitochondria and glycolysis. © Springer-Verlag 2012.


Arista-Nasr J.,Instituto Nacional Of Nutricion | Trolle-Silva A.,Instituto Nacional Of Nutricion | Aguilar-Ayala E.,Institute Seguridad Y Servicios Sociales Of Los Trabajadores Del Estado | Martinez-Benitez B.,Instituto Nacional Of Nutricion
Actas Urologicas Espanolas | Year: 2016

Objectives In most prostate biopsies, the seminal epithelium is easily recognised because it meets characteristic histological criteria. However, some biopsies can mimic malignant or premalignant prostatic lesions. The aims of this study were to analyse the histological appearance of the biopsies that mimic adenocarcinomas or preneoplastic prostatic lesions, discuss the differential diagnosis and determine the frequency of seminal epithelia in prostate biopsies. Methods We consecutively reviewed 500 prostate puncture biopsies obtained using the sextant method and selected those cases in which we observed seminal vesicle or ejaculatory duct epithelium. In the biopsies in which the seminal epithelium resembled malignant or premalignant lesions, immunohistochemical studies were conducted that included prostate-specific antigen and MUC6. The most important clinical data were recorded. Results Thirty-six (7.2%) biopsies showed seminal epithelium, and 7 of them (1.4%) resembled various prostate lesions, including high-grade prostatic intraepithelial neoplasia, atypical acinar proliferations, adenocarcinomas with papillary patterns and poorly differentiated carcinoma. The seminal epithelium resembled prostate lesions when the lipofuscin deposit, the perinuclear vacuoles or the nuclear pseudoinclusions were inconspicuous or missing. Five of the 7 biopsies showed mild to moderate cellular atypia with small and hyperchromatic nuclei, and only 2 showed cellular pleomorphism. The patients were alive and asymptomatic after an average of 6 years of progression. Conclusions The seminal epithelium resembles prostatic intraepithelial neoplasia, atypical acinar proliferations and various types of prostatic adenocarcinomas in approximately 1.4% of prostate biopsies. © 2015 AEU.


PubMed | Instituto Nacional Of Nutricion and Institute Seguridad Y Servicios Sociales Of Los Trabajadores Del Estado
Type: Journal Article | Journal: Actas urologicas espanolas | Year: 2016

In most prostate biopsies, the seminal epithelium is easily recognised because it meets characteristic histological criteria. However, some biopsies can mimic malignant or premalignant prostatic lesions. The aims of this study were to analyse the histological appearance of the biopsies that mimic adenocarcinomas or preneoplastic prostatic lesions, discuss the differential diagnosis and determine the frequency of seminal epithelia in prostate biopsies.We consecutively reviewed 500 prostate puncture biopsies obtained using the sextant method and selected those cases in which we observed seminal vesicle or ejaculatory duct epithelium. In the biopsies in which the seminal epithelium resembled malignant or premalignant lesions, immunohistochemical studies were conducted that included prostate-specific antigen and MUC6. The most important clinical data were recorded.Thirty-six (7.2%) biopsies showed seminal epithelium, and 7 of them (1.4%) resembled various prostate lesions, including high-grade prostatic intraepithelial neoplasia, atypical acinar proliferations, adenocarcinomas with papillary patterns and poorly differentiated carcinoma. The seminal epithelium resembled prostate lesions when the lipofuscin deposit, the perinuclear vacuoles or the nuclear pseudoinclusions were inconspicuous or missing. Five of the 7 biopsies showed mild to moderate cellular atypia with small and hyperchromatic nuclei, and only 2 showed cellular pleomorphism. The patients were alive and asymptomatic after an average of 6 years of progression.The seminal epithelium resembles prostatic intraepithelial neoplasia, atypical acinar proliferations and various types of prostatic adenocarcinomas in approximately 1.4% of prostate biopsies.


Carrillo S.,Instituto Nacional Of Nutricion | Rios V.H.,National Autonomous University of Mexico | Calvo C.,Instituto Nacional Of Nutricion | Carranco M.E.,Instituto Nacional Of Nutricion | And 2 more authors.
Journal of Applied Phycology | Year: 2012

Inclusion of sardine oil (SO) in diets for laying hens significantly increases the n-3 polyunsaturated fatty acids (PUFAs) in the egg, but these are more sensitive to oxidation, so the storage time and temperature can cause a decrease in their concentration. Therefore, the objective of this study was to determine the effect of algae Macrocystis pyrifera, Enteromorpha spp., and Sargassum sinicola on n-3 PUFA contents in eggs from laying hens fed diets supplemented with sardine oil and stored for different times (0, 15, and 30 days) and temperatures (20°C and 4°C), for 8 weeks. One hundred and twenty hens were divided into four treatments: T1 (commercial diet), T2 (2% SO + 10% M. pyrifera), T3 (2% SO + 10% Enteromorpha), and T4 (2% SO + 10% S. sinicola). At the end, 50 eggs per treatment were collected to quantify total lipids and egg n-3 PUFAs at different times (0, 15, and 30 days) and temperatures (20°C and 4°C) of storage. The results were analyzed using a 3 × 3 × 2 factorial design, and Tukey test to compare means (P < 0.05). The results show that M. pyrifera and S. sinicola had a better effect on eicosapentaenoic acid, while Enteromorpha was better for docosahexaenoic acid. In relation to time and temperature, the content of the fractions analyzed in the three treatments at 15 days/4°C had a lower loss compared with eggs analyzed at day 0/20°C. © 2012 Springer Science+Business Media B.V.


The main role of iodine is the synthesis of thyroid hormone. Thyroid hormones are related to brain development and metabolic regulation. Urinary iodine excretion is a useful and important indicator of the iodine status of a population. The World Health Organization (WHO) recommends that the median urinary iodine concentration in a population of pregnant women should range between 150 and 249 μg/L and in a population of school children it should range between 100 and 200 μg/L. Objective: To determine the prevalence of iodine deficiency in school children and pregnant women of Trujillo State, in the Andean region of Venezuela. Material and Methods: Cross-sectional survey of 400 school children aged 7-14 years and 300 pregnant women. Random urine samples were collected and analyzed for urinary iodine by Sandell-Kolthoff reaction. The criteria suggested by WHO to indicate iodine deficiency were applied. Results: Median urinary iodine for school children was 175 μg/L; and 6,25% of children had urinary iodine concentrations below 50 μg/L. Median urinary iodine for pregnant women was 228 μg/L; and 25% of pregnant women had urinary iodine concentrations below 150 μg/L. Conclusions: On the basis of the WHO criteria, the iodine intake in school children and pregnant women in Trujillo State, Venezuela, is adequate. Copyright ® 2011 por la Sociedad Argentina de Endocrinología y Metabolismo.


Toro Y.M.,Instituto Nacional Of Nutricion | Guerra M.,Simon Bolivar University of Venezuela | Espinoza C.,Instituto Nacional Of Nutricion | Newman A.,Simon Bolivar University of Venezuela
Anales Venezolanos de Nutricion | Year: 2011

Cereals are an important source of macronutrients that vary with the processing and preparation before their consumption. Cooking improves the taste of food, nice and makes them nicer and more digestible. The objective was to evaluate the changes produced in the proximate composition of precooked cornmeal, white rice, pasta and baby cereals at the time of preparation at home, aiming to update and provide data to the Venezuelan Food Composition Table (TCA). Eighty-seven samples of food products were purchased among precooked cornmeal, white rice, pasta and baby cereals. The samples were acquired at government outlets (MERCAL) and supermarket chains in different areas of Caracas. Eleven lots were obtained, which were analysed raw and cooked (usual home preparation). The analyses performed were moisture, protein, fat and ash, using official methods. The percentage results indicate significant differences (p <0.05) for the evaluated parameters between raw and cooked products for different brands. All raw cereals have humidity lower than 11.12%, and show protein percentage variations from 7.07 to 15.02, fat from 1.18 to 2.50 and ash from 0.40 to 2.38 meeting the provisions of the corresponding COVENIN standard. In the samples prepared for consumption, the percentage variations are: humidity between 56.31 and 75.97, protein from 2.53 to 5.38, fat from 0.36 to 1.22, and ash from 0.16 to 0 72. The major change these foodstuffs experience by domestic food processing is the moisture (water absorption and evaporation), which dilutes and modifies the components, which in the case of proteins are reduced by more than 50%, and thus for calculating the supply of macronutrients, the content should be considered as the foodstuff is consumed. The results obtained are similar to those reported in the 2000 version of the TCA.

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