Instituto Nacional Of Neurologia Y Neurocirugia Innn Manuel Velasco Suarez

Mexico City, Mexico

Instituto Nacional Of Neurologia Y Neurocirugia Innn Manuel Velasco Suarez

Mexico City, Mexico
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PubMed | National Polytechnic Institute of Mexico, Subdireccion de Ensenanza y Capacitacion, Laboratorio Of Medicina Genomica, Servicio de Electromiografia y Distrofia Muscular and 2 more.
Type: Journal Article | Journal: Muscle & nerve | Year: 2016

In this study, we determined normal levels of dysferlin expression in CD14Monocytes from 183 healthy individuals and 29 patients were immunolabeled, run on an FACScalibur flow cytometer, and analyzed by FlowJo software.The relative quantity of dysferlin was expressed as mean fluorescence intensity (MFI). Performance of this diagnostic test was assessed by calculating likelihood ratios at different MFI cut-off points, which allowed definition of 4 disease classification groups in a simplified algorithm.The MFI value may differentiate patients with dysferlinopathy from healthy individuals; it may be a useful marker for screening purposes. Muscle Nerve 54: 1064-1071, 2016.

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