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Chaves J.S.C.,Especialista em Vigilancia Sanitaria | Marin V.A.,Instituto Nacional Of Controle Of Qualidade Em Saude Incqs
Jornal Brasileiro de Patologia e Medicina Laboratorial | Year: 2010

Introduction: External Quality Control (EQC) is an important tool for quality assurance, assisting the laboratory in evaluating the efficiency of the analytical phase of its processes. An erroneous result of an analysis hinders the conclusion of diagnosis and the suitable treatment prescription to be followed. Health inspections in Clinical Laboratories (CL) in the State of Rio de Janeiro are made based on a sanitary inspection procedure issued by Directive SES/CVS 743, June 2006, RDC 302/2005 and current Brazilian legislation. EQC results observed from the total of 347 inspections conducted by the Division of Clinical Analysis Laboratories of the Department of Health and Civil Defense (LAC-SESDEC) during the period under review are presented below: 44% of 133 inspections performed in Clinical Analysis Laboratories had no contract with a profciency testing provider in 2006;38% of 95 inspections conducted in Clinical Analysis Laboratories did not have a contract with any profciency testing provider in 2007; and 35% of 119 inspections conducted in Clinical Analysis Laboratories had no contract with any proficiency testing provider in 2008. Sixty-two percent (134 laboratories) of 214 CL inspected in the years 2007 and 2008 had EQC, however, 65% of them did not record the corrective actions related to the nonconformities identified in a report issued by the profciency testing provider. Method: In this study, we evaluated the percentage distribution of the results of health inspections conducted in CL in the State of Rio de Janeiro from 2006 to 2008, registered at SESDEC, stating the number of CL that did not meet health requirements (item: "External Quality Control - EQC-Directive 743/2006") and the nature and the sector of these laboratories: intra and extra hospital clinical laboratories (publicly or privately owned hospitals and outsourced hospitals). Objective: Statistic evaluation of EQC in CL in the State of Rio de Janeiro during the period under review as to the nature of these laboratories. Source


Goncalves J.M.,Instituto Nacional Of Controle Of Qualidade Em Saude Incqs | de Souza M.D.C.,Federal University of Fluminense | Rocha R.C.C.,Pontifical Catholic University of Rio Grande do Sul | Medeiros R.J.,Laboratorio Of Experimentacao Animal Laean | Jacob S.C.,Instituto Nacional Of Controle Of Qualidade Em Saude Incqs
Ciencia Rural | Year: 2014

The concentrations of twenty-five elements (Al, As, Ba, Bi, Ca, Cd, Cr, Cu, Fe, Ga, K, Li, Mg, Mn, Mo, Na, Ni, Pb, Rb, Sb, Se, Sn, Sr, V and Zn) were determined in three edible mushrooms, Shiitake (Lentinula edodes), Black Shimeji (Pleurotus ostreatus) and Cardoncello (Pleurotus eryngyii) from Petrópolis, Rio de Janeiro, Brazil. Samples were collected along the year 2010 and their preparations were made after drying, milling, an acid pre-digestion and a decomposition procedure in a muffle furnace. The analytical techniques employed for the elements determination were Mass Spectrometry with Inductively Coupled Plasma and Flame Atomic Absorption Spectrometry. Two certified reference materials, Apple Leaves and Mussel Tissue, were used for the evaluation of the analytical procedure and recovery values around 98% were obtained. The results showed that the analyzed mushrooms have high levels of Cu, Fe, K, Mg, Mn and Zn containing more than 30% the recommended daily intake for these nutrients according to Brazilian legislation. These mushrooms presented a very low ratio Na/K. Regarding the levels of some contaminants, the mushrooms had concentrations of Cd, Pb and As below the recommended maximum limits allowed by Brazilian legislation. Source


Vega C.M.,Grupo de Estudos de Mamiferos Marinhos da Regiao Dos Lagos GEMM Lagos | Siciliano S.,Grupo de Estudos de Mamiferos Marinhos da Regiao Dos Lagos GEMM Lagos | Barrocas P.R.G.,Escola Nacional de Saude Publica FIOCRUZ | Hacon S.S.,Escola Nacional de Saude Publica FIOCRUZ | And 3 more authors.
Archives of Environmental Contamination and Toxicology | Year: 2010

Cadmium (Cd), mercury (Hg), and lead (Pb) were determined in samples of liver and breast muscles of first-year Magellanic penguins (Spheniscus magellanicus), from two different areas on the Brazilian coast, 35 on the Rio de Janeiro coast and 12 on the Rio Grande do Sul coast. In both areas, Cd concentrations in muscle samples were <0.025 μg/g. However, the Cd and Hg concentrations found in liver and Hg concentrations found in muscle showed a significant difference between the two regions. The geometric mean of the concentrations was higher in the specimens from Rio de Janeiro (Cd-6.8 μg/g; Hg- liver, 1.6 μg/g, and muscle, 0.4 μg/g wet weight) than in those from Rio Grande do Sul (Cd-2.3 μg/g; Hg-liver, 0.9 μg/g, and muscle, 0.1 μg/g wet weight). The site differences could be related to differences in diet influenced by geographic factors. Brazil's southeastern coast is highlyurbanized, and its coastal waters are contaminated by the waste of agricultural and industrial activities. There is a lack of information on the levels of heavy metals in S. magellanicus, however, their wide distribution and top position in the trophic chain make the use of stranded specimens an attractive source of information for monitoring heavy metals in the South Atlantic coast. © Springer Science+Business Media, LLC 2009. Source


De Araujo E.M.,Instituto Nacional Of Controle Of Qualidade Em Saude Incqs | Martins E.S.,Instituto Nacional Of Controle Of Qualidade Em Saude Incqs | Adams C.E.,University of Nottingham | Coutinho E.S.F.,FIOCRUZ | Huf G.,Instituto Nacional Of Controle Of Qualidade Em Saude Incqs
Jornal Brasileiro de Psiquiatria | Year: 2010

Objective: To evaluate the use of restraints in a large psychiatric hospital in Rio de Janeiro city, Brazil. Methods: A survey was carried on in August 2009. Data on sex, age, diagnostic, use and duration of restraints were collected from patients' notes. Result: Sample consisted on 66 patients, 59% women, with mean age of 44 years. During the study 24% of the patients were restrained at least once, but registering details of the procedure was not usual. There were no important adverse events. No associations were observed between restraints and sociodemographic and clinic variables. Conclusions: The use of restraints is a consistent practice in Rio de Janeiro's psychiatric hospitals: the same proportion was observed in three hospitals in distinct periods, 2001 and 2004, and this finding is in an intermediate position in relation to other studies results. There are no randomized trials to properly evaluate the benefits and risks of this practice, but the efficacy and safety of this intervention should be subject to the same scientific scrutiny as other treatments. Source


Presgrave O.,Brazilian Center for Validation of Alternative Methods Bra | Presgrave O.,Instituto Nacional Of Controle Of Qualidade Em Saude Incqs | Moura W.,Brazilian Center for Validation of Alternative Methods Bra | Moura W.,Instituto Nacional Of Controle Of Qualidade Em Saude Incqs | And 5 more authors.
ATLA Alternatives to Laboratory Animals | Year: 2016

The need for the creation of a Brazilian centre for the validation of alternative methods was recognised in 2008, and members of academia, industry and existing international validation centres immediately engaged with the idea. In 2012, co-operation between the Oswaldo Cruz Foundation (FIOCRUZ) and the Brazilian Health Surveillance Agency (ANVISA) instigated the establishment of the Brazilian Center for the Validation of Alternative Methods (BraCVAM), which was officially launched in 2013. The Brazilian validation process follows OECD Guidance Document No. 34, where BraCVAM functions as the focal point to identify and/or receive requests from parties interested in submitting tests for validation. BraCVAM then informs the Brazilian National Network on Alternative Methods (RENaMA) of promising assays, which helps with prioritisation and contributes to the validation studies of selected assays. A Validation Management Group supervises the validation study, and the results obtained are peer-reviewed by an ad hoc Scientific Review Committee, organised under the auspices of BraCVAM. Based on the peer-review outcome, BraCVAM will prepare recommendations on the validated test method, which will be sent to the National Council for the Control of Animal Experimentation (CONCEA). CONCEA is in charge of the regulatory adoption of all validated test methods in Brazil, following an open public consultation. Source

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