Trenhago P.R.,Laboratorio Nacional Of Computacao Centifica |
Trenhago P.R.,Instituto Nacional Of Ciencia E Tecnologia Em Medicina Assistida Por Computacao Centifica |
Fernandes L.G.,Federal Rural University of Rio de Janeiro |
Fernandes L.G.,Instituto Nacional Of Ciencia E Tecnologia Em Medicina Assistida Por Computacao Centifica |
And 6 more authors.
International Journal for Numerical Methods in Biomedical Engineering | Year: 2016
This study presents a lumped model for the human cardiorespiratory system. Specifically, we incorporate a sophisticated gas dissociation and transport system to a fully integrated cardiovascular and pulmonary model. The model provides physiologically consistent predictions in terms of hemodynamic variables such as pressure, flow rate, gas partial pressures, and pH. We perform numerical simulations to evaluate the behavior of the partial pressures of oxygen and carbon dioxide in different vascular and pulmonary compartments. For this, we design the rest condition with low oxygen requirements and carbon dioxide production and exercise conditions with high oxygen demand and carbon dioxide production. Furthermore, model sensitivity to more relevant model parameters is studied. © 2016 John Wiley & Sons, Ltd.