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Almeda-Valdes P.,Instituto Nacional Of Ciencias Medicas Y Nutricion Salvador Zubiran | Cuevas-Ramos D.,Instituto Nacional Of Ciencias Medicas Y Nutricion Salvador Zubiran | Mehta R.,Instituto Nacional Of Ciencias Medicas Y Nutricion Salvador Zubiran | Munoz-Hernandez L.,Instituto Nacional Of Ciencias Medicas Y Nutricion Salvador Zubiran | And 8 more authors.
BMC Endocrine Disorders | Year: 2015

Background: Alterations in postprandial metabolism have been described in familial combined hyperlipidemia (FCH); however, their underlying mechanisms are not well characterized. We aimed to identify factors related to the magnitude of postprandial lipemia and apolipoprotein (apo) A-V levels in subjects with FCH. Methods: FCH cases (n = 99) were studied using a standardized meal test. Abdominal obesity was assessed using the waist to hip ratio (WHR). A linear regression model was performed to investigate the variables associated with the triglycerides incremental area under the curve (iAUC). Independent associations between metabolic variables and apo A-V iAUC were also investigated in a randomly selected subgroup (n = 44). The study sample was classified according to the presence of fasting hypertriglyceridemia (≥150 mg/dL) and abdominal obesity (WHR ≥0.92 in men and ≥0.85 in women) to explore differences in parameters. Results: The fasting apo B-48 levels (r = 0.404), and the WHR (r = 0.359) were independent factors contributing to the triglycerides iAUC (r2 = 0.29, P < 0.001). The triglycerides iAUC was independently associated with the apo A-V iAUC (r2 = 0.54, P < 0.01). Patients with both hypertriglyceridemia and abdominal obesity showed the most robust triglycerides and apo A-V postprandial responses. Conclusions: In patients with FCH the fasting apo B-48 level is the main factor associated with postprandial lipemia. Abdominal obesity also contributes to the magnitude of the postprandial response. © 2014 Almeda-Valdes et al.; licensee BioMed Central Ltd.

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