Silva K.L.,Instituto Nacional Of Cancer Inca And Programa Of Pos Graduacao Em Oncologia Inca |
de Souza P.S.,Instituto Nacional Of Cancer Inca And Programa Of Pos Graduacao Em Oncologia Inca |
Nestal de Moraes G.,Instituto Nacional Of Cancer Inca And Programa Of Pos Graduacao Em Oncologia Inca |
Moellmann-Coelho A.,Hospital do Cancer I |
And 3 more authors.
Leukemia Research | Year: 2013
P-glycoprotein (Pgp) and XIAP co-expression has been discussed in the process of the acquisition of multidrug resistance (MDR) in cancer. Here, we evaluated XIAP and Pgp expression in chronic myeloid leukemia (CML) samples, showing a positive correlation between them. Furthermore, we evaluated the effects of imatinib in XIAP and Pgp expression using CML cell lines K562 (Pgp-) and K562-Lucena (Pgp+). Imatinib increased XIAP and Pgp expression in K562-Lucena cells, while in K562 cells a downregulation of these proteins was observed, suggesting that imatinib induces an increment of MDR phenotype of CML cells that previously exhibit high levels of Pgp/XIAP co-expression. © 2013 Elsevier Ltd.