Instituto Nacional Of Cancer Inca And Programa Of Pos Graduacao Em Oncologia Inca

Rio de Janeiro, Brazil

Instituto Nacional Of Cancer Inca And Programa Of Pos Graduacao Em Oncologia Inca

Rio de Janeiro, Brazil

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Silva K.L.,Instituto Nacional Of Cancer Inca And Programa Of Pos Graduacao Em Oncologia Inca | de Souza P.S.,Instituto Nacional Of Cancer Inca And Programa Of Pos Graduacao Em Oncologia Inca | Nestal de Moraes G.,Instituto Nacional Of Cancer Inca And Programa Of Pos Graduacao Em Oncologia Inca | Moellmann-Coelho A.,Hospital do Cancer I | And 3 more authors.
Leukemia Research | Year: 2013

P-glycoprotein (Pgp) and XIAP co-expression has been discussed in the process of the acquisition of multidrug resistance (MDR) in cancer. Here, we evaluated XIAP and Pgp expression in chronic myeloid leukemia (CML) samples, showing a positive correlation between them. Furthermore, we evaluated the effects of imatinib in XIAP and Pgp expression using CML cell lines K562 (Pgp-) and K562-Lucena (Pgp+). Imatinib increased XIAP and Pgp expression in K562-Lucena cells, while in K562 cells a downregulation of these proteins was observed, suggesting that imatinib induces an increment of MDR phenotype of CML cells that previously exhibit high levels of Pgp/XIAP co-expression. © 2013 Elsevier Ltd.

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