Instituto Nacional da Propriedade Industrial

Rio de Janeiro, Brazil

Instituto Nacional da Propriedade Industrial

Rio de Janeiro, Brazil
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Coelho M.L.V.,Federal University of Rio de Janeiro | Coelho M.L.V.,Instituto Nacional da Propriedade Industrial | de Souza Duarte A.F.,Federal University of Rio de Janeiro | De Freire Bastos M.C.,Federal University of Rio de Janeiro
Current Topics in Medicinal Chemistry | Year: 2017

One of the biggest challenges faced presently by clinicians is the emergence of multidrug -resistant pathogens that can infect humans and animals. To control the infections caused by such pathogens the development of new drugs is required. Bacteria are a rich source of ribosomally -synthesized antimicrobial peptides known as bacteriocins, which are characterized by the presence of a self-defense immunity system. Labionin-containing lantibiotics and sactibiotics are posttranslationally modified bacteriocins with peculiar features. Labionin-containing peptides belong to subclass Ic lantibiotics in which the carbacyclic triamino triacid labionin, a structural variant of lanthionine, and a methyl-substitute labionin derivative are found, giving the molecule a labyrinthine structure. Sactibiotics are circular or linear peptides belonging to a distinct bacteriocin class (class V) which is characterized by the presence of cross-linkages formed by the thiol group of cysteine residues and the α-carbon of acceptor amino acids. A few examples of these bacteriocins have been described in the literature to date, although putative gene clusters with the potential to encode such peptides can be found in the genome of many bacterial species. Some peptides already under study exhibit potential biotechnological applications because of their remarkable antibacterial or antiviral activities, as well as their analgesic activity. Therefore, in this review, the main findings concerning these peptides will be addressed and discussed, with an emphasis on their potential use in clinical settings. © 2017 Bentham Science Publishers.

Jannuzzi A.H.L.,Brazilian National Institute of Technology | Vasconcellos A.G.,Instituto Nacional da Propriedade Industrial
Cadernos de Saude Publica | Year: 2017

The backlog in processing patent applications in Brazil has persisted since the enactment of Law 9,279/1996, when the country resumed granting patents on drugs. The agencies responsible for granting such patents, namely the Brazilian National Patent and Trademark Office (INPI) and the Brazilian National Health Surveillance Agency (Anvisa) cite technical and administrative reasons for the backlog. However, little research has focused on the economic impacts for health due to the inefficiency of the Brazilian patent system. The current study thus proposes a methodology to estimate the extent to which government procurement of medicines is burdened by the backlog in drug patent applications. According to the results, a total of more than BRL 14 million (USD 4.5 mil-lion) is spent unnecessarily per year by the Federal Government on just one antiretroviral drug due to the extension of the respective patent’s life. Measures to resolve this situation are urgently needed in the three branches of government. These include hiring more staff for the INPI, analysis of bills of law under review in the two houses of the Brazilian Congress to amend the Industrial Property Law, and ruling on direct class action claims of unconstitutionality to suppress the legal mechanisms that allow extending the life of patents. © 2017, Fundacao Oswaldo Cruz. All rights reserved.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: INNOSUP-3-2014 | Award Amount: 3.00M | Year: 2015

The main goal of the VIP4SME project is to sustainably enhance Intellectual Property (IP) support services to SMEs in order to allow them to understand the value of the intellectual capital they create and own, and to define strategies and management practices allowing them to better turn this capital into commercial values and competitiveness. This challenge will be jointly addressed by 31 National Intellectual Property Offices (NIPOs) from EU member states and countries participating in Horizon2020 together with 22 local partners working in close cooperation with NIPOs and which are mostly business support providers (BSPs) having easy access to their local SMEs. Synergies with other IP stakeholders and especially international organisations (EPO, OHIM, Benelux Office for Intellectual Property, WIPO) will be created. Training contents, tools and IP support services specifically designed and corresponding to identified needs of SMEs will be adapted or newly created, managed and made available to all project partners, in order to serve the improvement of IP support in all participating countries. Through an implementation plan, defining quantitative objectives for each country, and a project organisation supporting all participants in the practical implementation of new IP training and IP services, it will be ensured that at least 3,500 SMEs will be reached by high value IP support activities. Communication activities, including via the joint website, will be either targeted toward the diffusion of specific information such as cross-boarder IP information and other relevant information on the business use of IP, or toward promotion of the services and activities made available by the VIP4SME project and benefiting directly SMEs.

Da Silva G.,Instituto Nacional da Propriedade Industrial | Iha K.,Brazilian Technological Institute of Aeronautics
Journal of Aerospace Technology and Management | Year: 2012

Hypergolic reactions may be useful in civil and military applications. In the area of rocket propulsion, they constitute a potential field due to the reduced weight and complexity of fuel injection systems, allowing yet controlled use of the propulsors. This manuscript aimed at presenting different hypergolic systems and their particularities, comparing them with chemical propulsion systems, which are most commonly employed in rocket motors, for example.

da Silva G.,Instituto Nacional da Propriedade Industrial | Rufino S.C.,Instituto Nacional da Propriedade Industrial | Iha K.,Brazilian Technological Institute of Aeronautics
Journal of Aerospace Technology and Management | Year: 2013

The research for low toxicity and no damage to the environment has stimulated the development of specific investigation lines in many areas. Inevitably, the criteria for safe handling, sensitivity and, above all, specific impulse (efficiencies) of propellant compositions are still superior in relation to ecological appeals. Nowadays, however, the solid or liquid propulsion, as aerospace as military, has already compounds to efficiency and eco-friendly characteristics. This study aimed at describing "green" alternatives to propulsive systems.

Brandao R.R.,Instituto Nacional da Propriedade Industrial | Moriconi L.,Federal University of Rio de Janeiro
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2015

We study the electron/hole transport in puddle-disordered and rough graphene samples which are subject to in-plane magnetic fields. Previous treatments, mostly devoted to regimes where the electron/hole scattering wavelengths are larger than the surface height correlation length, are based on the use of transport equations with appropriate forms for the collision term. We point out in this work, as a counterpoint, that classical Lorentz force effects, which are expected to hold when the Fermi level is far enough away from the charge neutral point, can be heuristically assessed through disordered Boltzmann equations that contain magnetic-field dependent material derivatives, and keep the zero magnetic-field structure of the collision term. It turns out that the electric conductivity tensor gets a peculiar nondiagonal component, induced by the in-plane magnetic field that crosses the rough topography of the graphene sheet, even if the projected random transverse magnetic field vanishes in the mean. Numerical estimates of the transverse conductivities suggest that they are suitable of observation under conditions which are within the reach of up-to-date experimental methods. © 2015 Elsevier B.V. All rights reserved.

Coelho M.L.V.,Federal University of Rio de Janeiro | Coelho M.L.V.,Instituto Nacional da Propriedade Industrial | Coutinho B.G.,Federal University of Rio de Janeiro | Cabral da Silva Santos O.,Federal University of Rio de Janeiro | And 2 more authors.
Research in Microbiology | Year: 2014

Aureocin A70, which is produced by Staphylococcus aureus A70, is the only four-component bacteriocin described thus far. The genetic determinants responsible for its production are arranged as three transcriptional units encoded by the 7.9-kb plasmid pRJ6. While the transcriptional unit formed by the genes aurABCD encodes the bacteriocin structural peptides, a second divergent gene, aurT, codes for an ABC transporter involved in bacteriocin externalization. The third transcriptional unit is composed of two genes, orfAB, whose functions were hitherto unknown. RT-PCR analysis of orfAB expression revealed that they are arranged as an operon. When orfAB, either with or without the transcriptional terminator found downstream of orfB, was expressed in two different S. aureus strains sensitive to aureocin A70, all strains became immune to this bacteriocin. Cloning of orfB alone, with or without the transcriptional terminator, confirmed orfB participation in immunity, although full immunity was not observed. An increase in immunity was achieved when two copies of orfB were cloned oriented with the exogenous Plac promoter present in the expression vector pT181mcs. orfB (here referred to as aurI) was shown to be responsible for aureocin A70 immunity, but the full immunity phenotype seems to depend on translational coupling involving orfA, which encodes a putative transcriptional regulator, and aurI. © 2013 Institut Pasteur.

De Souza Antunes A.M.,Instituto Nacional da Propriedade Industrial | De Souza Antunes A.M.,Federal University of Rio de Janeiro
Quimica Nova | Year: 2013

The main aim of this paper was to contribute to reflections in Brazil on the need to transfer knowledge held at universities and R&D institutions over to companies, i.e. to transfer scientific knowledge of chemistry to technology. It discusses how the competitiveness of countries is increasingly dependent on their technological capacity. The chemicals industry is a fundamental driver of social, environmental, economic and industrial indicators of sustainable development. In Brazil, the chemicals industry's deficit has grown over the last three decades. Patents are important sources of information because patent documents contain 75% of all technological information available. The National Institute of Industrial Property in Brazil has created a Technology Observatory with the purpose of identifying and analyzing technological information contained in patent documents within the ambit of partnerships with government entities or business associations, in order to support their technology-related decision-making processes. The paper gives examples of ethanol and biotechnology patent documents, including pharmaceuticals, of which there are very few in Brazil. However, a few of the patent applications identified are filed in Brazil, giving the country the opportunity to transform this scientific knowledge into technology by means of partnership agreements with companies. Finally, the paper presents information on the patent applications filed by the world's leading chemicals companies as measured by their revenues, and the respective numbers of patent applications in the last five years in organic chemistry and polymers, sectors in which Brazil is currently dependent on imports for over 50% of its needs. The patent assignees in these sectors in Brazil are also identified, and the paper concludes that Brazil needs to invest in the development of professionals, providing clearly-defined career paths in technology innovation teams at R&D institutions, and to foster more initiatives such as the creation of a new research and innovation entity, EMBRAPII, since investing in science and technology is a prerequisite for knowledge production, industrial property, economic development and, consequently, the competitiveness of the country. Copyright © 2013 Sociedade Brasileira de Quimica.

Codognoto L.,University Camilo Castelo Branco | Winter E.,Instituto Nacional da Propriedade Industrial | Doretto K.M.,University of Campinas | Monteiro G.B.,University of Campinas | Rath S.,University of Campinas
Microchimica Acta | Year: 2010

Monolayers of 2-mercapto-5-methylbenzimidazole (MMB) were prepared on a polycrystalline gold electrode via a self-assembly process to produce a self-assembled monolayer. The resulting electrode was investigated by cyclic voltammetry and electrochemical impedance spectroscopy, and applied to the determination of chloramphenicol (CAP) in a pharmaceutical formulation using flow injection analysis along with amperometric detection. The amperometric cell was operated at -0.75 V (vs Ag/AgCl) at a flow rate of 3 mL min -1. The method was applied to the determination of CAP in ophthalmic solutions, and its performance was compared to a previously validated HPLC method. The response to CAP is linear in the range from 0.050 to 1.000 μmol L -1 (r = 0.9990), and the limit of detection is 44 μmol L -1. © Springer-Verlag 2010.

de Luna A.J.,Instituto Nacional da Propriedade Industrial | Santos D.A.,Instituto Nacional da Propriedade Industrial
Environmental Science and Pollution Research | Year: 2016

Worldwide, year by year, Fenton’s Technologies have been highlighted in both academic and patent scopes, in part due to their proven efficiency as environment-friendly technologies destined to the abatement of organic pollutants, and also by their growing interest to produce industrial applications. Thus, aiming to understand the effective dynamic between two worlds, academy vs patents, the present study performs a comparative analysis about publications on Fenton-based Technologies (FbT). Therefore, in this work, technological foresight techniques were adopted focusing on patent and non-patent databases, employing for this, the Web of Science (WoS) database as a prospecting tool. The main results for the last decade point out to a strong increment of the Fenton’s Technologies, as much in R&D as in patent applications in the world. Chinese Universities and firms command the scenario. There is an expressive gap between the academic and patent issues. © 2016 Springer-Verlag Berlin Heidelberg

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