Pineda A.,Instituto Mexicano Of Seguro Social |
Verdin-Teran S.L.,National Autonomous University of Mexico |
Camacho A.,Hospital General Regional No 72 |
Moreno-Fierros L.,National Autonomous University of Mexico
Archives of Medical Research | Year: 2011
Background and Aims: Few studies have examined the presence of Toll-like receptors (TLRs) in term placentas from women with preeclampsia, such, have focused on TLR-4 and TLR-2 analysis. Whereas an increase in TLR-4 immunostaining has been observed in preeclampsia, it is even higher in placentas with chorioamnionitis compared with normal pregnancy. Expression of TLR-2 has not been associated with preeclampsia. The relationship of TLR-3 and TLR-9, which may recognize dsRNA or DNA, either derived either from microorganisms or from apoptotic cells and thus may be involved with this pathology, has not been studied in term placentas. We undertook this study to determine if there are changes in the expression and localization of TLR-2, TLR-4, TLR-3 and TLR-9 in preeclamptic term placentas as compared with normal placentas. Methods: A prospective, cross-sectional and comparative study was done in a group of ten patients with 38-40 gestation weeks, both in preeclamptic and control cases. Immunofluorescence detection of TLRs was performed in samples of placenta and analyzed by confocal microscopy. Results: It was observed that TLR-2, TLR-3, TLR-4 and TLR-9 were expressed both in normal and preeclamptic placentas, in the trophoblast, at the vascular endothelium (where TLR-2 and TLR-9 staining was pronounced), and at placental villous stroma, although increased expression was detected in preeclampsia. In addition, co-localization of TLR-2 and TLR-4 as well as of TLR-3 and TL9 was found in the trophoblast. Conclusions: TLR-2, -3, -4 and -9 expressions are increased in preeclamptic placentas. However, more studies are required to determine the role of TLRs in pregnancy immunology and to establish its relationship with preeclampsia. © 2011 IMSS.
Belinson J.L.,Cleveland Clinic |
Salmeron J.,Instituto Mexicano Of Seguro Social
International Journal of Cancer | Year: 2011
Even in the era of highly effective human papillomavirus (HPV) prophylactic vaccines, substantial reduction in worldwide cervical cancer mortality will only be realized if effective early detection and treatment of the millions of women already infected and the millions who may not receive vaccination in the next decade can be broadly implemented through sustainable cervical cancer screening programs. Effective programs must meet three targets: (i) at least 70% of the targeted population should be screened at least once in a lifetime, (ii) screening assays and diagnostic tests must be reproducible and sufficiently sensitive and specific for the detection of high-grade precursor lesions (i.e., CIN2+), and (iii) effective treatment must be provided. We review the evidence that HPV DNA screening from swabs collected by the women in their home or village is sufficiently sound for consideration as a primary screening strategy in the developing world, with sensitivity and specificity for detection of CIN2+ as good or better than Pap smear cytology and VIA. A key feature of a self-collected HPV testing strategy (SC-HPV) is the move of the primary screening activities from the clinic to the community. Efforts to increase the affordability and availability of HPV DNA tests, community education and awareness, development of strong partnerships between community advocacy groups, health care centers and regional or local laboratories, and resource appropriate strategies to identify and treat screen-positive women should now be prioritized to ensure successful public health translation of the technologic advancements in cervical cancer prevention. Copyright © 2011 UICC.
De Haro-Rodriguez M.A.,Instituto Mexicano Of Seguro Social |
Gallardo-Vidal L.S.,Instituto Mexicano Of Seguro Social |
Martinez-Martinez M.L.,Instituto Mexicano Of Seguro Social |
Camacho-Calderon N.,Autonomous University of Queretaro |
And 2 more authors.
Psicooncologia | Year: 2014
Objetive: To identify factors relating to the strategies for coping with breast cancer recently diagnosed patients. Methods: cross-sectional design, descriptive study of correlation among patients with breast cancer at the Clinica de Mama of the Hospital General Regional N°1 (HGR N°1) and Unidad Medica de Atencion Ambulatoria (UMAA), Instituto Mexicano del Seguro Social, Queretaro, Mexico in 2011. 98 patients of all ages with this diagnosis were studied with a background of diagnosis of between six to twelve months. Sociodemographic variables were studied (age, schooling, occupation, marital status), type of family, type of treatment received, and capability for coping strategies by them with “Inventory of strategies of coping”,modified and adapted in Spain by Cano et al. (2007) and reproduced in Mexico by Nava et al.(2010). In all procedures were applied with ethical considerations. An analysis was carried out using descriptive statistics, Spearman´s Rho, Pearson´s r and X2. Results: The predominant emotion upon hearing the diagnosis was fear (28,6%), the most coping strategy was problem solving. The related factors with the ability to cope were age, schooling, type of treatment received. Conclusions: Type of family, treatment received, age and schooling are strongly related tocoping strategies among patients with recent diagnosed breast cancer. © Asociación de Psicooncología de Madrid.
Mendoza-Pinto C.,systemIC |
Mendoza-Pinto C.,Instituto Mexicano del Seguro Social IMSS |
Garcia-Carrasco M.,systemIC |
Garcia-Carrasco M.,Instituto Mexicano del Seguro Social IMSS |
And 12 more authors.
Clinics | Year: 2013
Objective: To identify the prevalence and factors associated with cervical human papillomavirus infection in women with systemic lupus erythematosus METHODS: This cross-sectional study collected traditional and systemic lupus erythematosus-related disease risk factors, including conventional and biologic therapies. A gynecological evaluation and cervical cytology screen were performed. Human papillomavirus detection and genotyping were undertaken by PCR and linear array assay. results: A total of 148 patients were included, with a mean age and disease duration of 42.5±11.8 years and 9.7±5.3 years, respectively. The prevalence of squamous intraepithelial lesions was 6.8%. The prevalence of human papillomavirus infection was 29%, with human papillomavirus subtype 59 being the most frequent. Patients with human papillomavirus were younger than those without the infection (38.2±11.2 vs. 44.2±11.5 years, respectively; p = 0.05), and patients with the virus had higher daily prednisone doses (12.8±6.8 vs. 9.7±6.7 mg, respectively; p = 0.01) and cumulative glucocorticoid doses (14.2±9.8 vs. 9.7±7.3 g, respectively; p = 0.005) compared with patients without. Patients with human papillomavirus infection more frequently received rituximab than those without (20.9% vs. 8.5%, respectively; p = 0.03). In the multivariate analysis, only the cumulative glucocorticoid dose was associated with human papillomavirus infection. CONCLUSIONS: The cumulative glucocorticoid dose may increase the risk of human papillomavirus infection. Although rituximab administration was more frequent in patients with human papillomavirus infection, no association was found. Screening for human papillomavirus infection is recommended in women with systemic lupus erythematosus. © 2013 clinics.
Garcia Carrasco M.,systemIC |
Garcia Carrasco M.,Instituto Mexicano del Seguro Social |
Garcia Carrasco M.,Autonomous University of Puebla |
Mendoza Pinto C.,systemIC |
And 11 more authors.
Neurogastroenterology and Motility | Year: 2013
Background: Irritable bowel syndrome (IBS) impairs quality of life (HRQOL), as does systemic lupus erythematosus (SLE). Both are more common in women and are associated with fibromyalgia (FM). However, the relationship between IBS and SLE and its impact on HRQOL has not been explored. Therefore, we aimed to study the frequency and features likely to influence the presence of IBS-type symptoms in SLE and their impact on HRQOL. Methods: Female patients with SLE were studied. The presence of IBS-type symptoms and bowel habit subtype were established by Rome III criteria and HRQOL was assessed using the SF-36. Fibromyalgia and depression were assessed using the American College of Rheumatology criteria and CES-D scale, respectively. Key Results: A total of 105 consecutive patients (43.62 ± 11.34 years old) were included; 48.6% had IBS-type symptoms (SLE+IBS) and were classified as IBS-C: 23.5%, IBS-D: 37.3%, and IBS-M: 39.2%. In addition, 23.8% had FM. SLE+IBS vs Non-IBS SLE patients had higher SLE activity scores (2.55 ± 1.65 vs 1.74 ± 2.19; p = 0.03), were more likely to have FM (33.0% vs 14.8%; p = 0.02) and depression (41.1% vs 25.9%, p = 0.04). Logistic multivariate analysis showed that IBS-type symptoms were associated with FM (OR = 2.85, 95% CI: 1.11-7.43) and depression (OR = 1.07, 95% CI: 1.02-1.13). Finally, SLE+IBS vs Non-IBS SLE patients had lower SF-36 scores (49.65 ± 18.57 vs 62.67 ± 18.14; p = 0.02). Conclusions & Inferences: IBS-type symptoms are highly prevalent among women with SLE and are associated with FM and depression. SLE+IBS patients had worse HRQOL vs Non-IBS SLE, independently of FM status. We suggest that treating IBS symptoms may improve HRQOL in women with SLE. © 2013 John Wiley & Sons Ltd.
Jauregui-Renaud K.,Instituto Mexicano del Seguro Social |
Cruz-Gomez N.S.,Instituto Mexicano del Seguro Social |
Villanueva-Padron L.A.,Instituto Mexicano Of Seguro Social
Archives of Medical Research | Year: 2013
Background and Aims: We undertook this study to estimate the limits of agreement of repeated measures of static posturography on healthy adults and to assess the use of those limits on the interpretation of variations observed during vestibular rehabilitation of patients with chronic, peripheral vestibular disease. Methods: Twenty healthy adults and 30 vestibular patients accepted to participate. At baseline and at weeks 4, 6 and 8 of follow-up, posturography was performed with the eyes open or closed, while adding or not a layer of foam rubber to the base of support. The Dizziness Handicap Inventory was administered to patients prior to rehabilitation and at week 8. Results: At baseline, a difference between groups was observed on the sway area (. p < 0.05). Healthy subjects showed no statistical difference among the four recordings (repeatability of measurements from 85-100%). Vestibular patients showed differences among the four recordings on the area and the length/average speed of sway (. p <0.05); individual differences from baseline exceeding the limits of agreement were observed on the sway area. A decrease on the Dizziness Handicap Inventory (≥18 points) was observed on 19 patients, from whom 12 (63, 95% CI 53-73%) showed a change on the sway area (eyes closed) that was larger than the limits of agreement. Conclusions: In healthy subjects, intra-subject repeated recordings of the area and the length/average speed of sway may be reliable at intervals of 4, 6 and 8 weeks. The sway area (without vision) may be a useful sway component, among others, to follow-up vestibular patients with chronic, peripheral disease during rehabilitation. © 2013 IMSS.
Ocampo-Barrio P.,Instituto Mexicano Of Seguro Social |
Perez-Mejia A.N.,Instituto Mexicano Of Seguro Social
Semergen | Year: 2010
Objective: To describe and analyze the beliefs and perceptions regarding obesity in obese persons with who are beneficiaries of the Family Medicine Unit 94. Material and Methods: A qualitative, observational, cross-sectional and analytic study made from the perspective of symbolic interactionism carried out in a sample of 8 persons over 18years with not problems in hearingand language, with body mass 430Kg/m 2, who had no other chronic degenerative and psychiatric disease, who agreed to participate voluntarily. Their beliefs and perceptions were grouped into four suppositions: body image, risk for health, social relationship and reconducive treatments. Information was gathered using individual interviews, recorded and transcribed and classified under the different categories of the suppositions. The information was analyzed from Symbolic Interactionism and Tridimensional Analysis of Ethos. Results: The sample was made up of 6 women and 2 men. One had grade 5 obesity, two grade 2 and one grade 3. They associated obesity with success and vitality and considered themselves as "rather fat " but not as "obese." They felt discriminated and rejected because of their eating habits, consuming more food as a challenging attitude. Conclusions: Obesity needs to be studied using an interdisciplinary approach that would make it possible to consider the biological, social and cultural factors of the individual. © 2009 Elsevier España, S.L. and SEMERGEN.
Qualitative impact of cognitive impairment on daily life activities of patients with recently diagnosed multiple sclerosis [Impacto cualitativo de fallas cognitivas sobre las actividades de la vida diaria en pacientes con esclerosis múltiple de reciente diagnóstico]
Jimenez-Lopez J.L.,Instituto Mexicano Of Seguro Social |
Kleinert-Altamirano A.P.I.,Instituto Mexicano Of Seguro Social |
Rodriguez-Galindo D.M.,Instituto Mexicano Of Seguro Social |
Molina-Carrion L.E.,Instituto Mexicano Of Seguro Social
Archivos de Neurociencias | Year: 2012
Objective: to know the qualitative impact of cognitive impairment on daily life activities of patients with recently diagnosed multiple sclerosis (MS). Material and methods: patients with MS consecutively diagnosed in the previous six months underwent a neuropsychological test (Programa Integrado de Exploración Neuropsicológica - Test Barcelona) to measure their cognitive function. The daily life activities were assessed using the World Health Organization Disability Assessment Schedule II (WHODAS-II). Associations between impaired cognitive function and daily life activities affected were analyzed using the exact Fisheŕs test. Statistical significance was defined as p<0.05. Results: 17 patients were enrolled, 10 females and 7 males. 76% were employed. All of them scored cognitive function under normal percentile of the assessed areas with the exception of some corresponding to language. Only some praxis related functions showed association of statistical significance with mild difficult to carry on well the most important tasks in job. Conclusions: all the patients in this sample with recently diagnosed MS showed subtle cognitive impairment that affected mildly their performance in job. The qualitative assessment, instead of quantitative, of cognitive function in early stage o MS may allow to identify target functions to rehabilitate, with the purpose of delay early retirement of job. These preliminary results need to be confirmed with larger samples using control group. ©INNN, 2012.