Instituto Leonidas & Maria Deane

Manaus, Brazil

Instituto Leonidas & Maria Deane

Manaus, Brazil

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Cornel A.J.,University of California at Davis | Brisco K.K.,University of California at Davis | Tadei W.P.,National Institute of Amazonian Research | Rafael M.S.,National Institute of Amazonian Research | And 6 more authors.
Memorias do Instituto Oswaldo Cruz | Year: 2016

Salivary gland polytene chromosomes of 4th instar Anopheles darlingi Root were examined from multiple locations in the Brazilian Amazon. Minor modifications were made to existing polytene photomaps. These included changes to the breakpoint positions of several previously described paracentric inversions and descriptions of four new paracentric inversions, two on the right arm of chromosome 3 and two on the left arm of chromosome 3 that were found in multiple locations. A total of 18 inversions on the X (n = 1) chromosome, chromosome 2 (n = 7) and 3 (n = 11) were scored for 83 individuals from Manaus, Macapá and Porto Velho municipalities. The frequency of 2Ra inversion karyotypes in Manaus shows significant deficiency of heterozygotes (p < 0.0009). No significant linkage disequilibrium was found between inversions on chromosome 2 and 3. We hypothesize that at least two sympatric subpopulations exist within the An. darlingi population at Manaus based on inversion frequencies. © Instituto Oswaldo Cruz - Fundação Oswaldo Cruz - Ministério da Saúde 2016.


PubMed | National Autonomous University of Mexico, University of Buenos Aires, University of Santiago de Chile and Instituto Leonidas & Maria Deane
Type: Journal Article | Journal: Trends in molecular medicine | Year: 2016

Despite political turmoil and economical crisis, research in Latin America has considerably advanced over recent decades. The present Point of View outlines our perspectives on the working conditions, successes, difficulties, limitations, and challenges of biomedical scientific communities in four Latin American countries: Argentina (G.A.R.), Brazil (M.L.), Chile (A.K.), and Mexico (Y.R.).

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