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Massone C.,Medical University of Graz | Talhari C.,Foundation Medicine | Ribeiro-Rodrigues R.,Federal University of Espirito Santo | Sindeaux R.H.M.,Pontifical Catholic University of Parana | And 4 more authors.
Expert Review of Anti-Infective Therapy | Year: 2011

An increase in leprosy among HIV patients, similar to that observed in patients with TB, was expected approximately 20 years ago. Studies conducted in the 1990s together with those reported recently seemed to indicate that a coinfection with HIV did not alter the incidence and the clinical spectrum of leprosy and that each disease progressed as a single infection. By contrast, in countries with a high seroprevalence of HIV, TB was noted to increase. Explanations may be provided by the differences in the incubation time, the biology and toxicity of Mycobacterium leprae and Mycobacterium tuberculosis. After the introduction of HAART the leprosy-HIV coinfection manifested itself as an immune reconstitution inflammatory syndrome (IRIS), typically as paucibacillary leprosy with type 1 leprosy reaction. The incidence of leprosy in HIV-infected patients has never been properly investigated. IRIS-leprosy is probably underestimated and recent data showed that the incidence of leprosy in HIV patients under HAART was higher than previously thought. © 2011 Expert Reviews Ltd. Source


do Nascimento C.R.,Federal University of Rio Grande do Sul | Delanina W.F.B.,Instituto Lauro Of Souza Lima Ilsl | Soares C.T.,Instituto Lauro Of Souza Lima Ilsl
Anais Brasileiros de Dermatologia | Year: 2012

Paracoccidioidomycosis is a chronic, subacute or rarely acute mycosis, with visceral and cutaneous involvement. It is potentially fatal. Children account for about 5-10% of cases. In this study, we describe the relevance of discussing possible differential diagnoses as well as the importance of early treatment. © 2012 by Anais Brasileiros de Dermatologia. Source


do Nascimento C.R.,Federal University of Rio Grande do Sul | Barreto J.A.,Instituto Lauro Of Souza Lima Ilsl | Filho M.C.,Instituto Lauro Of Souza Lima Ilsl
Anais Brasileiros de Dermatologia | Year: 2012

Lipomas are common benign mesenchymal tumors composed of mature fat cells that may or may not be surrounded by a thin, fibrous capsule. The link with trauma has already been described. Lipomas involving the fingers are extremely rare but must be considered in the differential diagnosis of benign soft tissue masses in this particular location. © 2012 by Anais Brasileiros de Dermatologia. Source


Wachholz P.A.,Instituto Lauro Of Souza Lima Ilsl | Masuda P.Y.,University of Sao Paulo | Nascimento D.C.,Instituto Lauro Of Souza Lima Ilsl | Taira C.M.H.,University of Sao Paulo | Cleto N.G.,Sao Paulo State University
Anais Brasileiros de Dermatologia | Year: 2014

Background: Chronic leg ulcer may have an impact on patients' quality of life. Objectives: This study aimed to identify the impact of leg ulcers on patient's quality of life using the Dermatology Life Quality Index and to define the main factors correlated with this perception. Method: Cross-sectional, non-probabilistic sampling study. We included patients with chronic leg ulcers being treated for at least 3 months. A sociodemographic and clinical survey was conducted to assess the profile of the ulcers. We administered a screening for depressive symptoms and the Dermatology Life Quality Index. We performed a descriptive statistical analysis, chi-square test and Mann-Whitney test for categorical data, Pearson for numeric variables, and multiple regression for categorical data. Results: Forty-one patients were assessed. Their mean age was 61.78 years. Venous ulcers (48.8%) were the most prevalent. Seventy-three percent of the sample perceived no impact/low impact on quality of life in the past week, and 26.8% perceived moderate/high impact. A multiple regression analysis identified the causes of lesion, pain related to the ulcers, time of onset, and severity of the depressive symptoms as the variables that had an influence on quality of life. Conclusions: The majority of the sample perceived low or no impact of the condition on the quality of the life. The variables etiology of the lesion (p<0.001), pain related to the ulcers (p=0.001), time of onset (p=0.006), and severity of the depressive symptoms (p<0.001) had an influence on the quality of life, suggesting the need for further studies with more robust designs to confirm the causal relationship between these characteristics and quality of life. © 2013 by Anais Brasileiros de Dermatologia. Source


Teixeira L.O.,Instituto Lauro Of Souza Lima Ilsl | Silva C.M.G.C.H.,Instituto Lauro Of Souza Lima Ilsl | Akamatsu H.T.,Instituto Lauro Of Souza Lima Ilsl | Barreto J.A.,University of Sao Paulo | And 2 more authors.
Anais Brasileiros de Dermatologia | Year: 2012

This article presents a case of relapse, with isolated neural manifestation, in a multibacillary patient previously treated with multidrug therapy for multibacillary leprosy (24 doses). The patient returned to the service six years after the end of treatment, with pain in hands and legs. He was investigated, and the serological monitoring showed an important increase in anti-phenolic glycolipid serum levels. A neural recurrence was suspected, since the patient had no new skin lesions. A new biopsy in the right ulnar nerve showed a bacilloscopy of 2 +, compatible with relapse. This is a literature review of the etiological, clinical, propedeutical and diagnostic aspects of this situation so poorly understood. © 2012 by Anais Brasileiros de Dermatologia. Source

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