Time filter

Source Type

Osorio E.Y.,University of Texas Medical Branch | Rodriguez L.D.,Instituto Colombiano Agropecuario Instituto Colombiano Agropecuario | Rodriguez L.D.,University of Texas Medical Branch | Bonilla D.L.,Baylor College of Medicine | And 6 more authors.
American Journal of Tropical Medicine and Hygiene | Year: 2012

Little information is available on transplacental transmission of Leishmania spp. We determined the frequency and impact of congenital infection caused by Leishmania panamensis or L. donovani in experimentally infected hamsters. A polymerase chain reaction showed that congenital transmission occurred in 25.8% (24 of 93) of offspring born to L. panamensis-infected hamsters and 14.6% (11 of 75) offspring born to L. donovani-infected hamsters. Mortality during lactation was higher in offspring born to L. panamensis-infected hamsters and offspring born to L. donovani-infected hamsters than controls, and lymphoproliferation to Leishmania was more frequent in offspring born to L. panamensis-infected hamsters (17.4%, 11 of 63) than in offspring born to L. donovani-infected hamsters (8.5%, 3 of 35). After weaning, only offspring born to L. donovani-infected hamsters had lower weight gain (P < 0.001) and hematocrit levels (P = 0.0045) than controls. Challenge of offspring born to L. panamensis-infected hamsters with L. panamensis showed no differences in lesion evolution, and offspring born to L. donovani-infected hamsters were more susceptible to L. donovani challenge than controls. Consequently, prenatal exposure of hamsters to L. donovani significantly increased the mortality risk and susceptibility to secondary homologous infection. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.

Loading Instituto Colombiano Agropecuario Instituto Colombiano Agropecuario collaborators
Loading Instituto Colombiano Agropecuario Instituto Colombiano Agropecuario collaborators