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Mexico City, Mexico

Patent
The Broad Institute Inc., Massachusetts General Hospital and Instituto Carlos Slim Of La Salud | Date: 2015-02-10

The present invention features a highly sensitive assay for detecting frameshift mutations for high throughput use. Also provided herein are methods for diagnosing or determining a predisposition for developing medullary cystic kidney disease type 1 (MCKD1) in a subject by detecting a frameshift mutation in the GC-rich variable number of tandem repeats (VNTR) sequence of the mucin 1 gene (MUC-1).


Tapia-Conyer R.,Instituto Carlos Slim Of La Salud | Gallardo-Rincon H.,Instituto Carlos Slim Of La Salud | Saucedo-Martinez R.,Instituto Carlos Slim Of La Salud
Gaceta Medica de Mexico | Year: 2012

The increasing prevalence of non-communicable diseases (NCDs) has impacted the health systems by demanding unbearable costs of care and diminishing people's quality of life. The Instituto Carlos Slim de la Salud, a non-profit organization, has developed the model Casalud to convene partnerships with state governments to establish a reengineering process of primary care clinics, improving the delivery of services and leveraging on the different technological platforms to connect them with the households. The model Casalud strengthens the delivery of services and increases the timely demand of care. It is actually implemented in seven states seeking a progressive scale-up. Source


Tapia-Conyer R.,Instituto Carlos Slim Of La Salud | Lyford S.,West Health Institute | Saucedo R.,Instituto Carlos Slim Of La Salud | Casale M.,West Health Institute | And 9 more authors.
International Journal of Telemedicine and Applications | Year: 2015

Background. Fetal and neonatal morbidity and mortality are significant problems in developing countries; remote maternal-fetal monitoring offers promise in addressing this challenge. The Gary and Mary West Health Institute and the Instituto Carlos Slim de la Salud conducted a demonstration project of wirelessly enabled antepartum maternal-fetal monitoring in the state of Yucatán, Mexico, to assess whether there were any fundamental barriers preventing deployment and use. Methods. Following informed consent, high-risk pregnant women at 27-29 weeks of gestation at the Chemax primary clinic participated in remote maternal-fetal monitoring. Study participants were randomized to receive either prototype wireless monitoring or standard-of-care. Feasibility was evaluated by assessing technical aspects of performance, adherence to monitoring appointments, and response to recommendations. Results. Data were collected from 153 high-risk pregnant indigenous Mayan women receiving either remote monitoring (n=74) or usual standard-of-care (n=79). Remote monitoring resulted in markedly increased adherence (94.3% versus 45.1%). Health outcomes were not statistically different in the two groups. Conclusions. Remote maternal-fetal monitoring is feasible in resource-constrained environments and can improve maternal compliance for monitoring sessions. Improvement in maternal-fetal health outcomes requires integration of such technology into sociocultural context and addressing logistical challenges of access to appropriate emergency services. © 2015 Roberto Tapia-Conyer et al. Source

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