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Coniglio R.I.,Instituto Bioquimico Clinico Integral SRL | Ferraris R.,Hospital Pedro Ecay | Prieto A.,Hospital Pedro Ecay | Vasquez L.A.,Sanatorio Austral | And 6 more authors.
Acta Bioquimica Clinica Latinoamericana | Year: 2013

Type 2 diabetes mellitus (T2DM) is very common in the population but not always diagnosed. Alterations in the metabolism of glucose (Glu) and the metabolic syndrome (MS) are presented years before T2DM. A cross-population study, randomized and stratified by socioeconomic level in 223 subjects aged 45 and over at risk for T2DM was performed. SM was determined according to AHA / NHLBI. Objectives: a) to determine the frequency of subjects with impaired fasting Glu and SM; b) to determine the relationship between different indices of insulin resistance (IR), QUICKI, HOMA, insulin (Ins) and Ins/Glu with MS and its components. Results: elevated fasting Glu (100-125 mg/dL) was 19.3% (males 22.1%, women 17.8% (ns)), Glu≥126 mg/dL, 2.2%, SM 38.1% (males 33.8%, women 40.4% (ns)). IR was associated with waist and triglycerides (p <0.001), HDL cholesterol and blood pressure (p<0.01). With ROC curves were found the cutoff values IR for predicting MS: QUICKI <0.33, HOMA>2.1, Ins>10 mU/L, Ins/Glu>1.8. HOMA-IR>2.1 vs MS showed: sensitivity 72.6%, specificity 70.1%, positive predictive value 60.4%, negative predictive value 80.3%. For logistic regression analysis found predictors of MS: HOMA> 2.1, OR=8.76 (95% CI 4.37-17.55), p<0.001; family history of diabetes, OR=4.74 (95% CI 2.23-10.05), p.0.001; low level of formal education OR=2.69 (95% CI 1.33-5.46), p=0.006. Conclusions: The frequency of impaired fasting Glu was no greater than for the general population but SM was very common in women. HOMA-IR> 2.1 and QUICKI <0.33 were strong predictors of SM associated with increases in waist and triglycerides. Family history of diabetes and low levels of formal education shaped a strong predictor of SM profile.

Coniglio R.I.,Bioquimica UBA | Coniglio R.I.,Fundacion Of La Asociacion Of Laboratorios Of Alta Complejidad Alac | Coniglio R.I.,Instituto Bioquimico Clinico Integral SRL | Nellem J.,Bioquimico | And 5 more authors.
Acta Bioquimica Clinica Latinoamericana | Year: 2011

The metabolic syndrome (MS) includes an aggregate of components that is associated with the risk of diabetes mellitus and atherosclerosis. The calculation of the global risk score (GR) for coronary disease (Framingham Study) allows their categorization. The objectives of this work were to describe: a) the frequency of the associations of the MS components; b) the distribution of the frequency of low, moderate and high GR values in employees with MS defined by the National Cholesterol Education Program (ATP III). From an observational and multicentric study of 2,806 employees of both sexes between 40-65 years old from Argentina 625 subjects with MS were selected. The frequency of subjects with three components was 67.4%, 28.6% with four, and 4% with five. The most frequent combination in men was central obesity with arterial pressure ≥130/85 mmHg or treated and triglycerides ≥150 mg/dL 26.5%. In women, it was similar but, 20.5% were with low HDL cholesterol. In men, 26.5% had MS without central obesity and 27.8% had MS with glucose ≥110 mg/dL. Moderate or high GR was found in 62.2% of men and 13.9% of women, but 37.8% of men and 86.1 % of women had low GR. The results showed the heterogeneity of MS presentation according to the frequency of its components, and they indicate the need to include GR in the clinical evaluation.

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