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Ruyatkina L.A.,Novosibirsk State Medical University | Iskhakova I.S.,Novosibirsk State Medical University | Nikolaev K.Y.,Institution of Internal and Preventive Medicine | Ruyatkin D.S.,Novosibirsk State Medical University
Diabetes Mellitus | Year: 2015

Most of the questions regarding vascular and rheological regulation related to normal health and disorders of carbohydrate metabolism remain unclear, which is important in the pathogenesis of angiopathy. Consequently, in the literature, there is no information about the function of endothelial vasomotion during occlusion. The present study investigated early postmenopausal women, when clinical, metabolic, and hemodynamic disturbances often manifest. Aim. To study the association between clinical and biochemical indicators of endothelial microcirculation in naturally postmenopausal women with different carbohydrate metabolism statuses. Materials and methods. We surveyed 94 postmenopausal women who were divided into three groups based on their carbohydrate metabolism status: group 1, type 2 diabetes mellitus (n = 52); group 2, prediabetes (n = 16); group 3, normoglycemia (n = 26). The following indicators were assessed: lipid profiles and anthropometric fasting plasma glucose, glycated hemoglobin, vascular endothelial growth factor (VEGF), and endothelin-1 levels. Microcirculation was evaluated by laser Doppler flowmetry (LDF). Statistical analysis was performed using SPSS software (version 17.0). Results. LDF parameters in group 3 were significantly different from group 1 during occlusion and reperfusion and also from group 2 in basal blood flow. During occlusion, the frequency of microcirculation oscillation was higher in group 1, whereas the amplitude of oxygen saturation oscillation was lower in group 3 than those in group 2. VraEr and Vra/mEr indicators during reperfusion in group 1 and VrfEf during basal blood flow in group 2 were higher than those in group 3; Vr parameters reflect the contribution of fluctuations in the relative erythrocyte volume in the probed area of skin to the modulation of vascular tone. In group 1, occlusal LDF indicators correlated with waist circumference, whereas VEGF, lipid profile parameters, and reperfusion parameters, VraEr correlated with systolic blood pressure and lipid profile. In group 2, VrfEf inversely correlated with VEGF levels, and in group 3, the frequency of microcirculation oscillation inversely correlated with endothelin-1 levels. Conclusions. We revealed the associations of metabolic, anthropometric, and hemodynamic factors as well as biochemical markers of endothelial dysfunction with microcirculation parameters in various modes of endothelial activity (basal, occlusion, and reperfusion) in postmenopausal women according to their carbohydrate metabolism status; we also describe the effect of age on microvasculature vasomotion. Source

Mustafina S.V.,Institution of Internal and Preventive Medicine | Rymar O.D.,Institution of Internal and Preventive Medicine | Sazonova O.V.,Novosibirsk State Medical University | Shcherbakova L.V.,Institution of Internal and Preventive Medicine | Voevoda M.I.,Institution of Internal and Preventive Medicine
Diabetes Mellitus | Year: 2016

Aim. A validation of the Finnish diabetes risk score (FINDRISC) was conducted among the Siberian population. FINDRISC was used to study the prevalence of risk factors for type 2 diabetes mellitus (T2DM) and to estimate the incidence of T2DM in high-risk groups during a 10-year observation period. Materials and methods. A total of 9,360 subjects aged between 45 and 69 years were enrolled in this cross-sectional, population- based study. FINDRISC was used to group 8,050 people without diabetes according to their risk for T2DM. Statistical analysis was performed using SPSS. Results. When a cutoff point of 11 was used to identify those with diabetes, sensitivity was 76.0% and specificity was 60.2%. The area under the receiver operating curve for diabetes was 0.73 (0.73 for men and 0.70 for women). More than one-third (31.7%) of the adult population of Novosibirsk was estimated to have medium, high or very high risk of developing T2DM in the next 10 years. Cases of T2DM estimated to occur during the 10 years of follow-up had significantly higher incidence of risk factors such as BMI ≥30 kg/m2, waist circumference >102 cm in men and >88 cm in women and a family history of T2DM and were more likely to take drugs to lower blood pressure. Conclusion. FINDRISC provided good results in our sample, and we recommend its use in the Siberian population. © Russian Association of Endocrinologists, 2016. Source

Kuntsevich A.K.,Institution of Internal and Preventive Medicine | Mustafina S.V.,Institution of Internal and Preventive Medicine | Malyutina S.K.,Institution of Internal and Preventive Medicine | Verevkin E.G.,Institution of Internal and Preventive Medicine | Rymar O.D.,Institution of Internal and Preventive Medicine
Diabetes Mellitus | Year: 2015

Aim. The aim of our cross-sectional study was to evaluate the nutrition (or diet) habits of people with type 2 diabetes mellitus (DM) in the urban population (45-69 years) of Novosibirsk. Materials and methods. We included 1,041 people with DM and 8,095 people without DM in this study. The nutrition data were obtained via a population survey using a questionnaire to assess the frequency of food consumption within the framework of HAPIEE, an international project. Results. The prevalence of DM was 11.4% in this study population. The nutrition intake analysis showed that carbohydrate consumption in both men and women with DM was significantly lower compared with that in those without DM, while fat and protein intake were significantly higher. In men with type 2 DM, the proportions of black bread, vegetables, dairy products and meat in the diet were significantly higher, while the proportions of white bread and sweets in the diet were significantly lower compared with their counterparts without DM. Women with DM also had significantly higher proportions of black bread, vegetables, dairy products, meat and fish in the diet and lower proportions of white bread, potatoes and sweets in the diet than the controls. The proportions of fruit, eggs and alcohol intake did not differ between the groups for both men and women. In men, there was also no difference in the proportions of potatoes, vegetables and fish intake between the groups. Conclusion. The diets of both patients with DM and the general population in Novosibirsk are not well balanced. Source

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