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Bhunia S.,Institution Association for the Cultivation of Science | Chatterjee N.,CSIR - Central Electrochemical Research Institute | Das S.,CSIR - Central Electrochemical Research Institute | Das Saha K.,CSIR - Central Electrochemical Research Institute | Bhaumik A.,Institution Association for the Cultivation of Science
ACS Applied Materials and Interfaces | Year: 2014

We have designed a urea functionalized novel nanoporous material, POP-PU, which showsaggregation induced white light emission in the presence of suitable polar solvents. This nanomaterial has been explored as a pseudowhite light emitter where the polymeric luminogen moiety can interact with the suitable polar solvent, leading to charge transfer. Thus, solvent assisted rotational freezing of nonrigid polymeric nanoparticles gives radiative emission and the whole solution emits white light with color temperature of 8533 K. This nanoporous material also holds the pockets (donor-donor-acceptor array) for specific biomolecular interaction. Among three pyrimidine based nucleotide bases, only cytosine can amplify the PL emission intensity of POP-PU and the other two bases cannot, suggesting its future potential as a biosensor. Further, this urea functionalized porous organic nanomaterial can be utilized as an efficient drug-delivery vehicle for liver cancer diagnostics and therapy based on the specific biomolecular interaction at its surface. © 2014 American Chemical Society.


Kumari V.,Institution Association for the Cultivation of Science | Chatterjee N.,CSIR - Central Electrochemical Research Institute | Das S.,CSIR - Central Electrochemical Research Institute | Bhunia S.,Institution Association for the Cultivation of Science | And 2 more authors.
RSC Advances | Year: 2015

We report the synthesis of self-aggregated mesoporous ZnS nanoparticles with large mesoscopic void spaces via anionic surfactant mediated templating pathway. High BET surface area and mesoporosity of the material has motivated us to use it as a drug-delivery vehicle employing doxorubicin as a chemotherapeutic drug. The study indicates the novel approach to restrict the leukemic cell proliferation by the induction of apoptosis has been achieved through the doxorubicin loaded mesoporous ZnS nanoparticle (MZns-Edox). We found concentration and time dependently inhibition of cell viability that provokes apoptosis via mitochondrial pathway with the generation of ROS and the destabilization of mitochondrial membrane permeability. It leads to the release of various apoptotic factors like AIF, EndoG, Cyt c that may activate the caspase pathway. In this study, we established the apoptotic induction property of the drug loaded mesoporous ZnS nanoparticles against leukemic cells. Thus, mesoporous ZnS nanomaterial based drug-delivery system can activates the apoptotic pathway in time dependent response with a minimal concentration of doxorubicin and it can regulates lymphocytic leukemia cell growth. © The Royal Society of Chemistry.


PubMed | Institution Association for the Cultivation of Science
Type: Journal Article | Journal: ACS applied materials & interfaces | Year: 2014

We have designed a urea functionalized novel nanoporous material, POP-PU, which showsaggregation induced white light emission in the presence of suitable polar solvents. This nanomaterial has been explored as a pseudowhite light emitter where the polymeric luminogen moiety can interact with the suitable polar solvent, leading to charge transfer. Thus, solvent assisted rotational freezing of nonrigid polymeric nanoparticles gives radiative emission and the whole solution emits white light with color temperature of 8533 K. This nanoporous material also holds the pockets (donor-donor-acceptor array) for specific biomolecular interaction. Among three pyrimidine based nucleotide bases, only cytosine can amplify the PL emission intensity of POP-PU and the other two bases cannot, suggesting its future potential as a biosensor. Further, this urea functionalized porous organic nanomaterial can be utilized as an efficient drug-delivery vehicle for liver cancer diagnostics and therapy based on the specific biomolecular interaction at its surface.

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