Zdravkovic S.,Institute za Nuklearne Nauke Vinca |
Sataric M.V.,University of Novi Sad
Journal of Biosciences | Year: 2012
We rely on the helicoidal Peyrard-Bishop model for DNA dynamics. Interaction between nucleotides at a same site belonging to different strands is modelled by a Morse potential energy. This potential depends on two parameters that are different for AT and CG pairs, which is a possible source for inhomogeneity. It was shown recently (Zdravković and Satarić 2011) that certain values of these parameters bring about a negligible influence of inhomogeneity on the solitonic dynamics. We propose an experiment that should be carried out in order to determine the values of both of these parameters. © Indian Academy of Sciences.
Jovasevic J.S.,University of Belgrade |
Micic M.M.,Institute za Nuklearne Nauke Vinca |
Micic M.M.,Vinča Institute of Nuclear Sciences |
Suljovrujic E.H.,Institute za Nuklearne Nauke Vinca |
And 4 more authors.
Hemijska Industrija | Year: 2010
New hybrid hydrogels were prepared by radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid, polyvinylpyrrolidone) and silver salt. FTIR spectroscopy has confirmed binding of silver particles in hydrogels. Swelling studies performed in in vitro conditions showed dependence on PVP content and temperature. It can be seen that the antimicrobial activity of the Ag/P(HEMA/IA)PVP hybrid hydrogels depends on the PVP moiety and with the increase of PVP content the microbial contamination is more efficiently reduced. The best sensitivity was obtained for the polymers tested for antimicrobial activity against the yeast C. albicans, one of the most commonly encountered human pathogens, causing a wide variety of infections ranging from mucosal infections in generally healthy persons to life-threatening systemic infections in individuals with impaired immunity. A slightly less susceptible to antimicrobial effect of hydrogels was obtained for the Gram-positive bacteria S. aureus, where the reduction of cells was about 70% after two hours of exposure, for the sample with the highest PVP content. The least susceptible to the antimicrobial activity of hydrogels examined was the Gram-negative bacteria E. coli, where the percent of cell reduction was below 20%. Bearing in mind the influence of the time of exposure of microbes to the Ag/ /P(HEMA/IA)/PVP hybrid hydrogels, it was observed that the reduction of the number of cells depends on time, microbial culture and type of hybrid hydrogel sample. Due to their swelling and antimicrobial properties, silver/poly(2-hydroxyethyl methacrylate/itaconic acid)/poly(vinylpyrrolidone) hybrid hydrogles show potential to use in the field of biomedicine, especially for treatment of skin and burns in dermocosmetics.
Milicevic D.S.,Institute za Nuklearne Nauke Vinca |
Milicevic D.S.,Vinča Institute of Nuclear Sciences |
Suljovrujic E.H.,Institute za Nuklearne Nauke Vinca |
Suljovrujic E.H.,Vinča Institute of Nuclear Sciences
Hemijska Industrija | Year: 2010
In this paper, changes in structure and physical properties of stabilized isotactic polypropylene (iPP) were created by gamma irradiation, up to a dose of 700 kGy, in different media: air, deionized distilled (DD) water and acetylene. Two main effects occur when polyolefins, such as iPP, are subjected to ionizing radiation: crosslinking and scission of macromolecules. The domination of one or the other of these competitive processes is determined by both the structural peculiarities of the polymers and the experimental irradiation conditions. Gel and infrared (IR) spectroscopy measurements were used to determine the changes in the degree of network formation and oxidative degradation, respectively. Sol-gel analysis was studied in detail using the Charlesby-Pinner (C-P) equation. The radiation-induced changes in the structure and evolution of oxygen-containing species were also studied through dielectric loss (tan δ) analysis in a wide temperature and/or frequency range. Evolution of low temperature dielectric relaxations with gamma irradiation was investigated. The results showed that degradation was the major reaction in the initial step of irradiation, no matter what the atmosphere was. The C-P equation seemed applicable when stabilized iPP was irradiated within a certain dose range in various atmospheres. The iPP irradiated in acetylene/air had the lowest/highest values for oxidation level, dielectric losses, Dg and G(s)/G(x) values. The calculated Dg values are 1.5 and 5 times larger for the irradiation in DD water and air than for the acetylene. Furthermore, our data confirm that oxidation strongly affects the gel point but has a much lower effect on the G(s)/G(x) ratio. In the case of dielectric relaxation measurements, the connection between the oxidative degradation and dielectric properties is well established and is in good agreement with IR spectroscopy measurements. The amount of carbonyl, hydroperoxide and other polar groups is much higher for the irradiation in air than in other media, leading to higher dielectric losses. Disappearance of low temperature (δ and γ) relaxations with gamma radiation confirmed great sensitivity of iPP structure to radiation-induced changes. Complete "vanishing" of the γ relaxation in iPP samples irradiated in air is connected with a large radiation-induced oxidative degradation in this medium. Similar crosslinking, oxidation and dielectric behaviour was observed for the samples irradiated in water and acetylene, indicating DD water as a good crosslinking medium.
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE-2009-2-7-01 | Award Amount: 1.94M | Year: 2010
A number of epidemiological studies have consistently demonstrated the protective effects of fruits and vegetables with respect to several age related diseases. The aim of this project is to investigate the protective action of agents with potential use as functional food constituents with respect to cancer, diabetes and cardiovascular disease. In collaboration between EU and Indian research centers the proposal features a multipronged approach, where the protective action of various non-toxic agents are studied in vitro as well as in rodent models with respect to induction of DNA lesions, tumours and biomarkers for the development of diabetes, diabetic retinopathy and atherosclerosis. In addition, reduced availability of carcinogens and inhibition of their metabolic activation are investigated. Testing of the protective efficacy of functional food components in intervention cross-over studies in humans exposed to carcinogens, that are normally present at significant levels in the environment, represents an approach that has rarely been resorted to, and will be implemented under this project in Europe as well as in India using sophisticated molecular, cytogenetic and other analytical methods. Although there has been remarkable progress in our understanding of the processes that lead to neoplasia and diabetes, the mechanisms underlying chemoprevention are, in general, little understood. The results from this project are expected to provide an improved insight with respect to this topic.
Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: SiS-2009-188.8.131.52 | Award Amount: 5.34M | Year: 2010
European authorities and the international scientific community acknowledge the importance of Inquiry-Based Science and Mathematics Education (IBSME) to develop an integrated strategy for scientific literacy and awareness from primary to secondary school, reinforcing scientific careers. Scienceduc and Pollen FP6 projects as well as SINUS-Transfer have successfully implemented IBSME in a large number of European cities. Europe is now facing the urgent need to disseminate such approaches and enable all member States to have access, understand and implement them in a way that fits their own specificities. To go beyond best practices sharing and to provide effective know-how transfer at European level requires a dissemination model based on a systematic approach of IBSME at grassroots level, ensured by intermediary structures with successful experience in local IBSME implementation. The FIBONACCI project defines a dissemination process from 12 Reference Centres to 24 Twin Centres, based on quality and global approach. This will be done through the pairing of the former, selected for their large school-coverage and capacities for transfer of IBSME, with 12 Twin Centres 1 and 12 Twin Centres 2. These will receive training and tutoring for 2 years in order to become in turn Reference Centres and start disseminating. Transversal work between partners is organised through 5 major topics which will be explored through European training sessions and will lead to European guidelines in order to structure a common approach at European level. An external evaluation will be done to check achievement and quality. FIBONACCI will thus lead to the blueprint of a transfer methodology, valid for further Reference centre building in Europe. The project will be coordinated for 36 months by the Superior Normal School (France), with a shared scientific coordination with Bayreuth University. The Consortium will include 24 members over 21 countries, with endorsement from major institutions.
Agency: European Commission | Branch: FP7 | Program: CP-FP-SICA | Phase: ENV.2010.1.2.3-2 | Award Amount: 4.55M | Year: 2011
The project will examine the health impacts of greenhouse gas (GHG) reduction policies in urban settings in Europe, China and India, using case studies of 3-4 large urban centres and three smaller urban centres. Sets of realistic interventions will be proposed, tailored to local needs, to meet published abatement goals for GHG Emissions for 2020, 2030 and 2050. Mitigation actions will be defined in four main sectors: power generation/industry, household energy, transport and food and agriculture. The chief pathways by which such measures influence health will be described, and models developed to quantify changes in health-related exposures and health behaviours. Models will include ones relating to outdoor air pollution, indoor air quality and temperature, physical activity, dietary intake, road injury risks and selected other exposures. Integrated quantitative models of health impacts will be based on life table methods encompassing both mortality and morbidity outcomes modelled over 20 year time horizons. Where possible, exposure-response relationships will be based on review evidence published by the Comparative Risk Assessment initiative or systematic reviews. Uncertainties in model estimates will be characterized using a mathematical framework to quantify the influence of uncertainties in both model structure and parameter estimates. Particular attention will be given to economic assessments, both in terms of behavioural choices/uptake of various forms of mitigation measure (with new surveys to address evidence gaps), and in terms of health benefits and costs calculated from societal, health service and household perspectives. A decision analysis framework will be developed to compare different mitigation options. Experts and user groups will be consulted to define the mitigation questions to be examined, and the results will be discussed in consultative workshops scheduled for the final months of the project.
Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: ERACHAIRS-2013-1 | Award Amount: 2.80M | Year: 2014
Through the realization of MagBioVin project, the Institute of Nuclear Sciences Vinca, University of Belgrade (Serbia) receives important community support to upgrade its capacities related to the highly specialized research on activated magnetic nanoparticles (MNP) and radionuclide labeled magnetic nanoparticles for application in biosciences, pharmacy and medicine. This is planned to be realized by a set of comprehensive actions, such as engagement of eminent expert in the field (ERA Chair holder), bringing experimental facilities up to the most advanced EU-competitive level, cutting-edge trainings in reputable EU research institutions and intensive dissemination towards ERA, Universities and stakeholders. The Project foresees the key role of ERA Chair holder in improvement of organizational structure, research excellence and especially in communication with stakeholders. Organization of seven dedicated international workshops led by EU experts in the field, six extensive training programs for MagBioVin team members and the accent on intensified international collaboration, are few of the activities anticipated through Project implementation. These are designed to set solid foundations for a final goal: to rise both human and experimental capacities of the Vinca Institute to the level that ensures considerable scientific and technological impact within ERA and its ability to compete with leading EU research institutions on an equal basis.
Agency: European Commission | Branch: FP7 | Program: CP-CSA | Phase: Fission-2013-3.1.1 | Award Amount: 10.26M | Year: 2013
Within the OPERRA project, it is proposed that the MELODI Association, as a well-advanced network, takes the lead in establishing the necessary structures able to manage the long-term European research programmes in radiation protection, also taking advantage of the valuable experience gathered through the DoReMi network of excellence. Whilst in fields adjacent to low-dose risk research (radioecology, nuclear emergency management) scientific issues would continue to be hosted by the sister associations, Alliance and NERIS, these associations are encouraged to join MELODI to establish an umbrella structure as equal partners. OPERRA will exploit the synergies of EURATOM and other EC programmes considering the most relevant joint program areas and mechanisms for funding joint activities. The project will also strengthen the links with national funding programs as well as the European education and training structures. Also, it will take steps towards a greater involvement of those new Member States who could benefit from increased participation in the radiation research programmes. Finally, OPERRA will take steps to further integrate the joint use of infrastructures in European countries, and to develop and facilitate an easier access to research infrastructures. The final objective of this project is to build up an umbrella coordination structure that has the capacity in a legal and logistical sense to administer future calls for research in radiation protection as a whole (including low-dose risk, radioecology, nuclear emergency management, and also research activities related to the medical uses of ionizing radiation) on behalf of the European Commission. OPERRA will prepare the organisation for a first competitive call by the end of 2013 for projects in low-dose risk research and a second competitive call in 2014 for broader projects in radiation protection research, subject to the approval of EC services, with the support of Go-between administrator operator and an external advisory entity.
PubMed | Institute za nuklearne nauke Vinca
Type: Journal Article | Journal: Journal of biosciences | Year: 2012
We rely on the helicoidal Peyrard-Bishop model for DNA dynamics. Interaction between nucleotides at a same site belonging to different strands is modelled by a Morse potential energy. This potential depends on two parameters that are different for AT and CG pairs, which is a possible source for inhomogeneity. It was shown recently (Zdravkovic and Sataric 2011) that certain values of these parameters bring about a negligible influence of inhomogeneity on the solitonic dynamics. We propose an experiment that should be carried out in order to determine the values of both of these parameters.
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2012.6.5-1 | Award Amount: 12.70M | Year: 2012
CITI-SENSE will develop citizens observatories to empower citizens to contribute to and participate in environmental governance, to enable them to support and influence community and societal priorities and associated decision making. CITI-SENSE will develop, test, demonstrate and validate a community-based environmental monitoring and information system using innovative and novel Earth Observation applications. To achieve this, the project will: (i) raise environmental awareness in citizens, (ii) raise user participation in societal environmental decisions and (iii) provide feedback on the impact that citizens had in decisions. It will address the calls request for effective participation by citizens in environmental stewardship, based on broad stakeholder and user involvement in support of both community and policy priorities. The project aims to learn from citizen experience and perception and enable citizenship co-participation in community decision making and co-operative planning. The concept of CITI-SENSE rests on three pillars: technological platforms for distributed monitoring; information and communication technologies; and societal involvement. Three pilot case studies will focus on a range of services related to environmental issues of societal concern: combined environmental exposure and health associated with air quality; noise and development of public spaces, and indoor air at schools. Attention will be given to representativeness of citizen participation. The case studies will be designed in collaboration with citizens groups and decision makers. They will be based on distributed data collection using innovative static, portable and personal devices (low-cost reliable microsensor packs) that communicate with a data repositories through mobile phones or other devices. Development of participatory methods, data management strategies, and applications to facilitate exploitation of the data and information for policy, and society, will be done.