Institute Tecnologia Em Farmacos Farmanguinhos R Sizenando

Rio de Janeiro, Brazil

Institute Tecnologia Em Farmacos Farmanguinhos R Sizenando

Rio de Janeiro, Brazil
SEARCH FILTERS
Time filter
Source Type

Howie R.A.,University of Aberdeen | De Souza M.V.N.,Institute Tecnologia Em Farmacos Farmanguinhos R Sizenando | Pinheiro A.C.,Institute Tecnologia Em Farmacos Farmanguinhos R Sizenando | Kaiser C.R.,Federal University of Rio de Janeiro | Wardell S.M.S.V.,CHEMSOL
Zeitschrift fur Kristallographie | Year: 2011

The molecular structures of tert-butyl (S)-2-hydroxy-[N-(substituted- benzylidene)hydrazinyl-carbonyl]-ethylcarbamates, C15H 20N3O4X (3: X 1/4 H, o-OH, o-NO2, m-NO2 and p-CN), derived from L-serine, are formally rather similar. Despite the variation in substituent, X, triclinic (3: X 1/4 H), (3: X 1/4 o-OH), (3: X 1/4 m-NO2) and (3: X 1/4 p-CN) are isostructural and exhibit, with minor variations, the same fundamental intermolecular O-H-O and N-H-O hydrogen-bond connectivity in two-dimensions in layers of molecules. In monoclinic (3: X1/4 o-NO2), however, the oxygen atoms of the nitro group function as additional O-H-O and N-H-O hydrogen-bond acceptors resulting in a more complex form of two-dimensional connectivity. © by Oldenbourg Wissenschaftsverlag, München.


Howie R.A.,University of Aberdeen | De Souza M.V.N.,Institute Tecnologia Em Farmacos Farmanguinhos R Sizenando | Ferreira M.D.L.,Institute Tecnologia Em Farmacos Farmanguinhos R Sizenando | Kaiser C.R.,Federal University of Rio de Janeiro | Wardell S.M.S.V.,CHEMSOL
Zeitschrift fur Kristallographie | Year: 2010

The molecules of the 7-chloroquinoline-4-hydrazones of the variously substituted benzaldehydes, 5, of general formula C16H 11ClN3X with X = H, o-F, m-F or m-MeO corresponding to compounds (5: X = H), (5: X = o-F), (5: X = m-F) and (5: X = m-MeO), respectively, are formally rather similar. Compounds (5: X = H) and (5: X = o-F) are isostructural but otherwise the molecular packing and intermolecular interactions show unexpectedly wide variation throughout the series. In all 5 hydrogenbonds link the essentially planar molecules edge to edge to form chains. Combination of intermolecular hydrogen-bonds and π⋯π interactions creates three-dimensional connectivity in (5: X = H), (5: X = o-F) and, utilising the methoxy oxygen atom as acceptor for a C-H⋯O hydrogen-bond, (5: X = m-MeO). Significant connectivity is no more than two-dimensional in layers of molecules in (5: X = m-F). © by Oldenbourg Wissenschaftsverlag, München.

Loading Institute Tecnologia Em Farmacos Farmanguinhos R Sizenando collaborators
Loading Institute Tecnologia Em Farmacos Farmanguinhos R Sizenando collaborators