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Vellasco Junior W.T.,Federal University of Fluminense | Gomes C.R.B.,Institute Tecnologia em Farmacos Farmanguinhos | Vasconcelos T.R.A.,Federal University of Fluminense
Mini-Reviews in Organic Chemistry | Year: 2011

Benzoxathiolones and its derivatives are important pharmacophores with diversified pharmacological activities like antibacterial, antimycotic, antioxidant and anti-inflammatory. These different biological applications for benzoxathiolone compounds have motivated new studies in searching novel derivatives with better activity results and also other applications in pharmaceutical industry. Owing to the importance of this system, the aim of this review is to present the main aspects of the chemistry and biological properties of 1,3-benzoxathiol-2-ones. © 2011 Bentham Science Publishers Ltd. Source


Leishmania causes tegumental and visceral diseases called leishmaniasis. Disease control is possible interrupting the transmission cycle, but HIV co-infection, chemotheraphy toxicity and lack of a vaccine are paramount difficulties. So, is necessary to study new Leishmania molecules and investigate the possibility to develop rational drugs using these molecules as targets. Leishmania express many peptidases during their life, and cysteine are the most abundant protease and many inhibitors were developed but failed to kill parasites. On the other hand, inhibitors of serine proteases killed promastigotes, indicating the possibility of these enzymes to be important targets in the development of anti-Leishmania drugs. Source


Neuenfeldt P.D.,Federal University of Pelotas | Duval A.R.,Federal University of Pelotas | Drawanz B.B.,Federal University of Pelotas | Rosales P.F.,Federal University of Pelotas | And 4 more authors.
Ultrasonics Sonochemistry | Year: 2011

An efficient multicomponent reaction of arenealdehydes, mercaptoacetic acid and piperonilamine under ultrasound irradiation to afford 2-aryl-3-(piperonylmethyl)-1,3-thiazolidin-4-ones is reported. Applying this methodology, eleven heterocycles were synthesized and isolated in good yields after short reaction times. © 2010 Elsevier B.V. Source


Costa T.E.M.M.,Institute Tecnologia em Farmacos Farmanguinhos | Dias A.P.M.,Federal University of Fluminense | Scheidegger E.M.D.,Instituto Oswaldo Cruz
Ciencia e Saude Coletiva | Year: 2011

Since the commercial approve in 1996, the global area of transgenic crops has raised more than 50 times. In the last two decades, governments have been planning strategies and protocols for safety assessment of food and feed genetically modified (GM). Evaluation of food safety should be taken on a case-by-case analysis depending on the specific traits of the modified crops and the changes introduced by the genetic modification, using for this the concept of substantial equivalence. This work presents approaches for the risk assessment of GM food, as well as some problems related with the genetic construction or even with the expression of the inserted gene. Source


Ferreira M.D.L.,Institute Tecnologia em Farmacos Farmanguinhos | De Souza M.V.N.D.,Institute Tecnologia em Farmacos Farmanguinhos | Wardell S.M.S.V.,CHEMSOL | Tiekink E.R.T.,University of Malaya
Acta Crystallographica Section E: Structure Reports Online | Year: 2012

In the title compound, C19H18ClN3O 3, the r.m.s. deviation through the 23 non-H and non-meth-oxy atoms is 0.088 Å, indicating a planar mol-ecule with the exception of the meth-oxy groups. One meth-oxy group, surrounded on either side by the other meth-oxy groups, is almost normal to the benzene ring to which it is connected [C-O-Car-Car torsion angle = 81.64 (15)°]. In the crystal, N-H⋯O, C-H⋯O and π-π inter-actions [between quinoline residues; centroid-centroid distance = 3.4375 (8) Å] link mol-ecules into a three-dimensional architecture. Source

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