Institute Tecnologia e Pesquisa ITP

Aracaju, Brazil

Institute Tecnologia e Pesquisa ITP

Aracaju, Brazil
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Meneses M.O.,Institute Tecnologia e Pesquisa ITP | Dariva C.,Institute Tecnologia e Pesquisa ITP | Borges G.R.,Institute Tecnologia e Pesquisa ITP | Da Rocha S.R.P.,Virginia Commonwealth University | And 2 more authors.
Journal of Chemical and Engineering Data | Year: 2017

The development of polymeric systems for drug delivery has received attention with the aim of producing new systems as an alternative to conventional drug therapy. The design of new systems for this purpose in a compressed medium requires a knowledge of the phase behavior for the polymeric matrix in the high-pressure fluids. This work reports the phase equilibrium experimental data of binary systems involving poly(ethylene glycol) (PEG) with molecular weights of 1000 and 2000 g·mol-1 and 1,1,1,2-tetrafluoroethane (HFA-134a). The experimental data were obtained in a high-pressure variable-volume viewing cell based on the static synthetic method at temperatures from 287.4 to 334.2 K, pressures of up to 29.81 MPa, and a PEG concentration in the range of 1 to 7 wt %. Liquid-liquid equilibrium, liquid-liquid-vapor equilibrium, and, in some cases, solid-liquid equilibrium were observed under the experimental conditions of pressure, temperature, and compositions investigated. The experimental results show that temperature and pressure have significant influences on the solubility of PEG in HFA-134a. The solid-phase formation for the system PEG + HFA-134a, in the range of values investigated for temperature, pressure, and compositions, is influenced by the molecular weight of the polymer. © 2017 American Chemical Society.


PubMed | Federal University of Sergipe, Institute Tecnologia e Pesquisa ITP and Federal University of Rio Grande do Sul
Type: | Journal: BioMed research international | Year: 2014

Exposure to solar radiation, particularly its ultraviolet (UV) component, has a variety of harmful effects on human health. Some of these effects include sunburn cell formations, basal and squamous cell cancers, melanoma, cataracts, photoaging of the skin, and immune suppression. The beneficial photoprotective effects of topical formulations with the extract, Morinda citrifolia, have not been investigated. This present study aims to investigate the potential benefits of M. citrifolia topical application on the dorsal skin of mice, exposed to UVA-UVB light. Using 7 days of treatment, [before (baseline values) and 20h after UV exposure], the thickness, skin barrier damage (TEWL), erythema, and histological alterations were evaluated. The results showed that the formulations containing the extract protected the skin against UV-induced damage.


Fonseca Y.M.,University of Sao Paulo | Catini C.D.,University of Sao Paulo | Vicentini F.T.M.C.,University of Sao Paulo | Cardoso J.C.,Institute Tecnologia e Pesquisa ITP | And 2 more authors.
Journal of Pharmaceutical Sciences | Year: 2011

The present study investigated the potential use of topical formulations containing marigold extract (ME) (Calendula officinalis extract) against ultraviolet (UV)B irradiation-induced skin damage. The physical and functional stabilities, as well as the skin penetration capacity, of the different topical formulations developed were evaluated. In addition, the in vivo capacity to prevent/treat the UVB irradiation-induced skin damage, in hairless mice, of the formulation with better skin penetration capacity was investigated. All of the formulations were physically and functionally stable. The gel formulation [Formulation 3 (F3)] was the most effective for the topical delivery of ME, which was detected as 0.21 μg/cm 2 of narcissin and as 0.07 μg/cm 2 of the rutin in the viable epidermis. This formulation was able to maintain glutathione reduced levels close to those of nonirradiated animals, but did not affect the gelatinase-9 and myeloperoxidase activities increased by exposure to UVB irradiation. In addition, F3 reduced the histological skin changes induced by UVB irradiation that appear as modifications of collagen fibrils. Therefore, the photoprotective effect in hairless mice achieved with the topical application of ME in gel formulation is most likely associated with a possible improvement in the collagen synthesis in the subepidermal connective tissue. © 2010 Wiley-Liss, Inc.


PubMed | Rede de Biotecnologia do Nordeste RENORBIO, UFS and Institute Tecnologia e Pesquisa ITP
Type: | Journal: Bioresource technology | Year: 2015

The aim of this study was to evaluate the potential of Hancornia speciosa GOMES (mangaba) seeds as a novel matrix for the production of bio-oil. The study was divided into three steps: (i) characterization of the biomass (through elemental analysis (CHN), infrared spectroscopy (FTIR-ATR), thermogravimetry (TG), and determination of biomass composition; (ii) pyrolysis of mangaba seed to obtain the bio-oil; and (iii) characterization of the bio-oil (thermogravimetry and gas chromatography/mass spectrometry-GC/qMS). The TG of the sample showed a mass loss of around 90% in 450C. In the pyrolysis experiments the variables included temperature (450 and 600C), sample mass (5 and 11g) and prior heating (with or without), with the best conditions of 600C, 11g of seeds and prior heating of the furnace. The GC/qMS analysis identified carboxylic acids and hydrocarbons as the major components, besides the presence of other compounds such as furanes, phenols, nitriles, aldehydes, ketones, and amides.


Steffens C.,URI Integrated Regional University Brazil | Steffens C.,National Nanotechnology Laboratory for Agribusiness LNNA | Corazza M.L.,Federal University of Paraná | Franceschi E.,Institute Tecnologia e Pesquisa ITP | And 4 more authors.
Sensors and Actuators, B: Chemical | Year: 2012

The objective of this work was to develop gas sensors using three different techniques for the deposition of polyaniline film: (a) precipitation of polyaniline particles doped with dodecylbenzenesulfonic acid (DBSA) using supercritical carbon dioxide (SC-CO 2), (b) rapid expansion with SC-CO 2 (modified RESS) of polyaniline doped with DBSA, and (c) in situ polymerization polyaniline doped with chloridric acid. The sensors responses were evaluated at moisture and volatile organic compounds (VOCs). All of the sensors presented a satisfactory sensitivity and reversibility when exposed to VOCs. The films morphology was characterized by scanning electronic microscopy for field emission (FE-SEM). Results showed a difference regarding phase formation and behavior for the sensors obtained using SC-CO 2 coatings with polyaniline and by in situ polymerization, indicating that techniques the use of supercritical fluid techniques are promising in manufacturing such electronic devices. © 2012 Elsevier B.V. All rights reserved.


Freitas L.D.S.,UFS | Dariva C.,Institute Tecnologia e Pesquisa ITP | Jacques R.A.,Federal University of Rio Grande do Sul | Caramao E.B.,Federal University of Rio Grande do Sul
Separation and Purification Technology | Year: 2013

Pressurized liquid extraction (PLE) is a useful technology for performing quick extractions of organic compounds from a variety of matrices. In the presented study, PLE of oil from grape seed was performed, and the effect of varying some experimental parameters, such as solvent, extraction time, flush, amount of sample, number of extraction cycles and temperature, was determined. The yield and the main characteristics of the produced oil were measured. It was found that the solvent choice has an important influence on the mass yield of the grape seed oil when performing PLE. The best yield results were achieved, under all experimental conditions, when using dichloromethane as the extraction solvent. The temperature and the number of extraction cycles also demonstrated an influence on the mass yield of the oil. © 2013 Elsevier B.V. All rights reserved.


PubMed | Embrapa Tabuleiros Costeiros, Instituto Evandro Chagas IEC, Tiradentes University, University of Porto and 2 more.
Type: Journal Article | Journal: Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria | Year: 2016

This study reports on Kudoa spp. (Myxozoa, Multivalvulida) from the fish species Lutjanus analis, Bagre marinus, Aspistor luniscutis and Lutjanus jocu, which were caught in Aracaju, state of Sergipe, Brazil. The parasites formed oval plasmodia around the esophagus of L. analis, and elongated plasmodia inside the skeletal muscle of B. marinus, A. luniscutis and L. jocu. Host myoliquefaction was not observed in all the cases studied. The current study provides a morphological and morphometric description of each parasite as well as a comparison with all the species described worldwide. Lack of molecular data impaired specific identification of the parasites. The importance of these parasites is discussed and the need for further studies on infections in Brazilian fish is emphasized because of the high economic impact of some Kudoa species which cause liquefaction in hosts muscles and render these fish unsuitable for consumption.


Santos R.M.,Cid University Prof Jose Aloisio Of Campos Av Marechal Rondo S N | Santos A.O.,Cid University Prof Jose Aloisio Of Campos Av Marechal Rondo S N | Sussuchi E.M.,Cid University Prof Jose Aloisio Of Campos Av Marechal Rondo S N | Nascimento J.S.,Cid University Prof Jose Aloisio Of Campos Av Marechal Rondo S N | And 2 more authors.
Bioresource Technology | Year: 2015

The aim of this study was to evaluate the potential of Hancornia speciosa GOMES (mangaba) seeds as a novel matrix for the production of bio-oil. The study was divided into three steps: (i) characterization of the biomass (through elemental analysis (CHN), infrared spectroscopy (FTIR-ATR), thermogravimetry (TG), and determination of biomass composition; (ii) pyrolysis of mangaba seed to obtain the bio-oil; and (iii) characterization of the bio-oil (thermogravimetry and gas chromatography/mass spectrometry-GC/qMS). The TG of the sample showed a mass loss of around 90% in 450. °C. In the pyrolysis experiments the variables included temperature (450 and 600. °C), sample mass (5 and 11. g) and prior heating (with or without), with the best conditions of 600. °C, 11. g of seeds and prior heating of the furnace. The GC/qMS analysis identified carboxylic acids and hydrocarbons as the major components, besides the presence of other compounds such as furanes, phenols, nitriles, aldehydes, ketones, and amides. © 2015 Elsevier Ltd.


Nunes P.S.,Federal University of Sergipe | Bezerra M.S.,Federal University of Sergipe | Costa L.P.,Federal University of Sergipe | Cardoso J.C.,Institute Tecnologia e Pesquisa ITP | And 5 more authors.
Journal of Thermal Analysis and Calorimetry | Year: 2010

The purpose of this study was to evaluate the physical-chemical properties of collagen (CL) and usnic acid/collagen-based (UAC) films, using differential thermal analysis (DTA), thermogravimetry (TG/DTG), infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Both films were prepared by casting process using polyethylene glycol 1500 (PEG 1500) as plasticizer. In the spectrum of UAC, similar bands of the usnic acid are observed, indicating that the polymerization (film formation) did not affect the stability of the drug. Distinctly, DTA curve of UAC did not show an endothermic peak at 201 °C, indicative that the drug was incorporated into the polymeric system. These results were corroborated by the scanning electron microscopy (SEM). The TG/DTG curves of UAC presented a different thermal decomposition profile compared to the individual compounds and CL. These findings suggest the occurrence of molecular dispersion or solubilization of the drug in the collagen film. © 2010 Akadémiai Kiadó, Budapest, Hungary.


PubMed | Federal University of Sergipe and Institute Tecnologia e Pesquisa ITP
Type: Journal Article | Journal: Anais da Academia Brasileira de Ciencias | Year: 2016

The Portulaca oleracea L. (Portulacaceae) is a cosmopolitan species with a wide range of biological activities, including antioxidant and neuroprotective actions. We investigated the effects of P. oleracea extracts in a 6-hydroxydopamine rat model of Parkinsons disease, a debilitating disorder without effective treatments. Chemical profiles of aqueous and ethanolic extracts of whole plant were analyzed by thin layer chromatography and the antioxidant activity was assessed by 2,2-diphenyl-1-picrilhidrazila method. Male Wistar rats received intrastriatal 6-hydroxydopamine and were treated with vehicle or extracts (oral, 200 and 400 mg/kg) daily for two weeks. The behavioral open field test was conducted at days 1 and 15. Immunohistochemical analysis was performed 4 weeks after surgery to quantify tyrosine-hydroxylase cell counts in the substantia nigra pars compacta. Extracts presented antioxidant activity in concentrations above 300 g/kg. The chromatographic analysis revealed the presence of Levodopa, alkaloids, flavonoids, saponins, tannins, terpenoids and polysaccharides. Both extracts improved motor recovery 15 days after lesion and protected from tyrosine-hydroxylase cell loss after 4 weeks, but these effects were more evident for the aqueous extract. Because the dopamine precursor is present, in addition to antioxidant compounds and neuroprotective effects, P. oleracea can be considered as potential strategy for treating Parkinsons disease.

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