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Mobasher M.A.,Institute Investigaciones Biomedicas Alberto Sols CSIC UAM | Mobasher M.A.,Institute Salid Carlos III | De Toro-Martin J.,Institute Salid Carlos III | De Toro-Martin J.,Complutense University of Madrid | And 10 more authors.
Journal of Biological Chemistry

Background: PTP1B is a negative modulator of insulin receptor-mediated signaling.Results: Acetaminophen increased PTP1B in hepatocytes and impaired insulin signaling.Conclusion: PTP1B plays an essential role in the impairment of insulin signaling mediated by acetaminophen in hepatocytes.Significance: Chronic acetaminophen administration might be associated with insulin resistance in the liver. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Source

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