Institute of Salah Azaiez

Tunis, Tunisia

Institute of Salah Azaiez

Tunis, Tunisia
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Khlifi S.,HIGH-TECH | Jemaa H.B.,HIGH-TECH | Hmad H.B.,HIGH-TECH | Abaza H.,Institute of Salah Azaiez | And 5 more authors.
International Journal of Pharmacology | Year: 2016

Fenugreek (Trigonella foenum-graecum) seeds have been known as a traditional plant treatment for diabetes. The aims of this study were to determine the antioxidant activity of fenugreek seeds and to evaluate the antidiabetic and antihyperlipidemic effect of fenugreek seeds intake on diabetic patients. Sixty newly diagnosed diabetic patients were recruited for this study and have received two doses of fenugreek seeds (Z5 and 5 g) for 4 weeks. Phytochemicals analysis and antioxidant activity of Trigonella foenum-graecum seeds methanolic extract were also studied. The chemical analysis of fenugreek seeds exhibited a high level in total polyphenols (95 GAE g/g VM) and flavonoids (3.7 mg RE/g VM). Fenugreek seeds exertan important DPPH scavenging ability in terms of Trolox Equivalents (TE) with 1.03 ± 0.008 mg TE/g VM and also exhibited a high antioxidant potential according to ABTS test. In Tunisian type 2 diabetic patients, thead ministration of fenugreek seeds (2.5 and 5 g) for 4 weeks improved blood glucose level in dose-dependent. Total cholesterol and triglycerides rate were significantly decreased by the dose of 5g Trigonella foenum-graecum seeds. Moreover, daily oral intake ofourtreatment by diabetic subjects reduced significantly serum a-amylase activity. The present findings indicate that fenugreek seeds with abundant flavonoids and total polyphenols content may be a good adjuvant for the treatment of diabetes. © 2016 Sarra Khlifi et al.

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