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Lopez F.,University of Santiago de Compostela | Lopez F.,Institute Quimica Organica General CSIC | Mascarenas J.L.,University of Santiago de Compostela
Chemical Society Reviews

This feature review describes the development of catalytic [4+2] and [4+3] cycloadditions of allenes, as efficient and practical methodologies for assembling six and seven-membered cyclic systems. The different methodologies have been classified depending on the type of key reactive intermediate that was proposed in the catalytic cycle. This journal is © the Partner Organisations 2014. Source

Faustino H.,University of Santiago de Compostela | Alonso I.,University of Santiago de Compostela | Mascarenas J.L.,University of Santiago de Compostela | Lopez F.,University of Santiago de Compostela | Lopez F.,Institute Quimica Organica General CSIC
Angewandte Chemie - International Edition

Gold standard: Allenamides react with aldehydes or ketones having γ, δ, or ε alkenyl groups, upon activation with suitable gold catalysts, to provide oxa-bridged systems containing seven- to nine-membered carbocycles, in a formal cascade cycloaddition. By using chiral phosphoramidite/gold or bisphosphine/gold catalysts it is possible to obtain the oxa-bridged seven- and eight-membered rings with good to high enantioselectivity. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Gomez A.M.,Institute Quimica Organica General CSIC
Topics in Current Chemistry

This chapter summarizes the concepts and chemistry developed by Ley's group in relation to the relevance of reactivity tuning in oligosaccharide coupling reactions. The recognition that protecting groups affect the reactivity of glycosyl donors allowed Ley's group to make imaginative use of their 1,2-diacetal protecting groups. The combination of 1,2-diacetals with the presence of different anomeric leaving groups provides up to four different levels of reactivity. The exploitation of these reactivity levels in chemoselective glycosylation processes (reactivity tuning) has allowed the development of highly simplified routes to several complex oligosaccharides in step-wise or one-pot procedures. © 2011 Springer-Verlag Berlin Heidelberg. Source

Rasero-Almansa A.M.,CSIC - Institute of Materials Science | Corma A.,Polytechnic University of Valencia | Iglesias M.,CSIC - Institute of Materials Science | Sanchez F.,Institute Quimica Organica General CSIC
Green Chemistry

The multifunctional heterogeneous catalyst iridium-Zr-based MOF is able to effectively catalyze the hydrogenation of aromatic compounds in high yields under mild conditions. The catalyst was found to be highly active and reusable, giving similar reactivity and selectivity after at least five catalytic uses. This journal is © the Partner Organisations 2014. Source

Aljarilla A.,Complutense University of Madrid | Lopez J.C.,Institute Quimica Organica General CSIC | Plumet J.,Complutense University of Madrid
European Journal of Organic Chemistry

Metathetical processes play a prominent role in the development of useful transformations because of their mildness, tolerance of functional groups, and synthetic potential. On the other hand, carbohydrates have gained well-deserved relevance in the study of biological processes. This review summarizes a decade of efforts in the application of cross metathesis (CM) reactions to the preparation of some relevant glycoconjugates. Cross-metathesis processes have been successfully applied to carbohydrate substrates during the last decade to give rise to a variety of glycoconjugates, including glycosylamino acids, cyclodextrin derivatives, carbohydrate-based vaccines, oligosaccharides, and glycoporphyrins © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

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