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Diaz-Marrero A.-R.,Institute Productos Naturales y Agrobiologiea CSIC | De La Rosa J.M.,Institute Productos Naturales y Agrobiologiea CSIC | Brito I.,Institute Productos Naturales y Agrobiologiea CSIC | Darias J.,Institute Productos Naturales y Agrobiologiea CSIC | Cueto M.,Institute Productos Naturales y Agrobiologiea CSIC
Journal of Natural Products | Year: 2012

Dactylomelatriol (1), obtained from the sea hare Aplysia dactylomela, is the first naturally occurring omphalane-derived sesquiterpene from the marine environment. From this species the known chamigrene and modified bisabolene sesquiterpenes 2-6 were also isolated. The structure and relative configuration of 1 were established by spectroscopic evidence. Its chemical structure is related to omphalic acid, the unique terrestrial-derived omphalane sesquiterpene isolated from a liverwort. A biogenetic route for this compound is proposed. The antimicrobial activities of compounds 1-6 were evaluated against a panel of microorganisms. © 2012 The American Chemical Society and American Society of Pharmacognosy. Source

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