Institute Pesquisa e Desenvolvimento

São José dos Campos, Brazil

Institute Pesquisa e Desenvolvimento

São José dos Campos, Brazil
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Zuri J.T.S.C.,Institute Pesquisa e Desenvolvimento | Pilla V.,Federal University of Uberlandia | Oliveira C.S.,University of Sao Paulo
IFMBE Proceedings | Year: 2013

The feet are the main sources for human body sustentation, and the distribution of body mass occurs according to the needs of mechanical adaptation. Moreover, childhood obesity can cause ostheoarticular changes through over mass and decreasing of corporal stability. This study aimed to analyze the distribution of plantar pressure of female children (aged 6-10 years). The children were divided into three groups: control, overweight and obese, according to their Body Mass Index (BMI). The footprints were analyzed by FootWork platform and divided into three parts: the forefoot, midfoot and hindfoot. The average values of plantar pressure were compared in order to investigate the differences between the three classes of children. © 2013 Springer.


Fraga M.A.,FATEC SP CEETEPS | Pessoa R.S.,Institute Pesquisa e Desenvolvimento | Massi M.,Institute Ciencia e Tecnologia | Maciel H.S.,Institute Pesquisa e Desenvolvimento
Revista Materia | Year: 2014

This paper discusses the use of silicon carbide (SiC), in bulk and thin-film form, in MEMS (Micro-Electro-Mechanical Systems) sensors for extreme environment applications, especially in aerospace. The physical and chemical properties of SiC that make it a suitable material for electronic devices and sensors are described. Concepts, developments and applications of MEMS technology are presented. An overview of the current stage of development of SiC-based MEMS sensors and an analysis of research conducted in this area in Brazil and abroad, both in universities and industries are also presented. The recent progress made, difficulties encountered and the impact of these investigations are discussed as well as the outlook for the near future. © 2014, Universidade Federal do Rio de Janeiro. All rights reserved.


Acosta-Avalos D.,Brazilian Center for Research in Physics (CBPF) | Jedlicka L.D.L.,Institute Pesquisa e Desenvolvimento | Costa M.S.,Institute Pesquisa e Desenvolvimento | Barja P.R.,Institute Pesquisa e Desenvolvimento | Da Silva E.C.,State University of Norte Fluminense
International Journal of Thermophysics | Year: 2012

In the present work the phototoxic effect of methylene blue (MB) on Candida albicans cultures was studied using the photoacoustic spectroscopy (PAS) technique. An aliquot of 50 μL of C. albicans suspension - strain ATCC 10-231 - was incubated with 50 μL of MB solution (0.5 mg/mL), at room temperature. After the proper incubation time, a colony forming unit (CFU) with approximately 3 mm diameter was chosen in each plate. The CFU selected was irradiated using an InGaAlP laser during 20 s. After irradiation and new incubation, the CFUs were collected and stored at -70 C, until spectroscopy analysis. The spectroscopy analysis was performed using an open PAS setup. The study was conducted in different groups: (1) control (non-treated); (2) irradiated with laser light; (3) treated with MB (non-irradiated); and (4) treated with MB and irradiated with laser light. The PAS measurements were performed on C. albicans in a sterile physiological solution. The measurements indicate that the presence of MB and irradiation promotes a change in the redox state of the cells to the reduced state. The absorption spectrum after photodynamic therapy (PDT) was observed 12 h and 36 h later. It was inferred that PDT can be related to structural changes in cytochrome molecules after 36 h. It is concluded that MB can be an efficient photosensitizer in C. albicans through modification of the cytochrome molecule affecting the cell metabolism. © 2012 Springer Science+Business Media New York.


Pires-Oliveira D.A.A.,University Camilo Castelo Branco | Oliveira R.F.,University Camilo Castelo Branco | Pacheco-Soares C.,Institute Pesquisa e Desenvolvimento | Rocha R.F.,São Paulo State University
Osteoporosis International | Year: 2010

The aim of the present study was to determine the action of AsGA laser irradiation on bone repair in the tibia of osteopenic rats. The animals were randomly divided into eight experimental groups according to the presence of ovarian hormone (sham group) or the absence of the hormone (OVX group), as well as being irradiated or non-irradiated. Low-level 904-nm laser (50 mJ/cm 2) accelerated the repair process of osteopenic fractures, especially in the initial phase of bone regeneration. Introduction: The development of new techniques to speed the process of bone repair has provided significant advances in the treatment of fractures. Some attention recently focused on the effects of biostimulation on bone. Methods: Forty-eight adult rats were randomly divided into eight experimental groups (six animals in each group) according to the presence of ovarian hormone (sham group) or absence of the hormone (ovariectomized (OVX) group) as well as being irradiated or non-irradiated. For the application of low-level laser therapy, the animals were anesthetized with one third of the dose sufficient to immobilize the animal and irradiated with AsGa laser (904 nm, 50 mJ/cm2 for 2 s, point form and in contact). The control animals received the same type of manipulation as the irradiated animals, but with the laser turned off. Half of the animals were killed 7 days following the confection of the bone defect, and the other half were killed 21 days after the surgery. After complete demineralization, the tibias were cut cross-sectionally in the central region of the bone defect and embedded in paraffin blocks. The blocks were then cut in semi-seriated slices and stained with hematoxylin and eosin. Results: There was new bone formation in the animals in the OVX group with laser treatment killed after 7 days (p<0.001). The lowest percentage of bone formation was observed in the OVX without laser killed after 7 days (p>0.05). All animals killed after 21 days exhibited linear closure of the lesion. Conclusion: Low-level 904-nm laser (50 mJ/cm2) accelerated the repair process of osteopenic fractures, especially in the initial phase of bone regeneration. © 2010 International Osteoporosis Foundation and National Osteoporosis Foundation.


Martins M.A.S.,Institute Pesquisa e Desenvolvimento | Ribeiro D.G.,Institute Pesquisa e Desenvolvimento | dos Santos E.A.P.,Institute Pesquisa e Desenvolvimento | Martin A.A.,Institute Pesquisa e Desenvolvimento | And 2 more authors.
Biomedical Optics Express | Year: 2010

The contamination of the Raman scattering signal with luminescence is a well-known problem when dealing with biological media excited by visible light. The viability of the shifted-excitation Raman difference spectroscopy (SERDS) technique for luminescence suppression on Raman spectra of biological samples was studied in this work. A tunable Lithrow-configuration diode laser (γ = 785 and 830 nm) coupled (directly or by optical fiber) to a dispersive Raman spectrometer was employed to study two sets of human tissues (tooth and skin) in order to determine the set of experimental parameters suitable for luminescence rejection. It was concluded that systematic and reproducible spectra of biological interest can be acquired by SERDS. © 2010 Optical Society of America.


Lobo A.O.,National Institute for Space Research | Lobo A.O.,Brazilian Technological Institute of Aeronautics | Lobo A.O.,University of Paraíba Valley | Lobo A.O.,Institute Pesquisa e Desenvolvimento | And 7 more authors.
Materials Science and Engineering C | Year: 2012

It was presented a strong difference on cell adhesion and proliferation of functionalized vertically-aligned multi-walled carbon nanotube (VACNT) scaffolds compared to raw-VACNT. Biocompatibility in vitro tests were performed on raw-VACNT after superficial modification by oxygen plasma, which changes its superhydrophobic character to superhydrophilic. Two cytocompatibility tests were applied: 1) total lactate dehydrogenase colorimetric assay for the study of proliferating cells; and 2) cellular adhesion by scanning electron microscopy. Results showed that superhydrophilic VACNT scaffolds stimulate cell growth with proliferation up to 70% higher than normal growth of cell culture. © 2010 Elsevier B.V. All rights reserved.


De Lima F.M.,Institute Pesquisa e Desenvolvimento | Bjordal J.M.,Bergen University College | Bjordal J.M.,University of Bergen | Albertini R.,Centro Universitario Nove Of Julho Uninove | And 3 more authors.
Lasers in Medical Science | Year: 2010

Low-level laser therapy (LLLT) has been found to produce anti-inflammatory effects in a variety of disorders. Bronchial smooth muscle (BSM) hyperreactivity is associated with increased Ca +2 sensitivity and increased RhoA mRNA expression. In the current study, we investigated if LLLT could reduce BSM contraction force and RhoA mRNA expression in tumor necrosis factor-α (TNF-α)-induced BSM hyperreactivity. In the study, 112 male Wistar rats were divided randomly into 16 groups, and BSM was harvested and suspended in TNF-α baths for 6 and 24 h, respectively. Irradiation with LLLT was performed with a wavelength of 660 nm for 42 s with a dose of 1.3 J/cm 2. This LLLT dose was administered once in the 6-h group and twice in the 24-h group. LLLT significantly decreased contraction force in BSM at 6 h (TNF-α + LLLT: 11.65±1.10 g/100 mg of tissue) (F=3115) and at 24 h (TNF-α+LLLT: 14.15±1.1 g/100 mg of tissue) (F=3245, p<0.05) after TNF-α, respectively, when compared to vehicle-bathed groups (control). LLLT also significantly decreased the expression of RhoA mRNA in BSM segments at 6 h (1.22±0.20) (F=2820, p<0.05) and 24 h (2.13±0.20) (F=3324, p<0.05) when compared to BSM segments incubated with TNF-α without LLLT irradiation. We conclude that LLLT administered with this protocol, reduces RhoA mRNA expression and BSM contraction force in TNF-α-induced BSM hyperreactivity. © 2010 Springer-Verlag London Ltd.


Carvalho L.F.C.S.,Institute Pesquisa e Desenvolvimento | Neto L.P.M.,Institute Pesquisa e Desenvolvimento | Oliveira I.P.,Institute Pesquisa e Desenvolvimento | Rangel J.L.,Institute Pesquisa e Desenvolvimento | And 3 more authors.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2016

In the clinical daily life various lesions of the oral cavity have shown different aspects, generating an inconclusive or doubtful diagnosis. In general, oral injuries are diagnosed by histopathological analysis from biopsy, which is an invasive procedure and does not gives immediate results. In the other hand, Raman spectroscopy technique it is a real time and minimal invasive analytical tool, with notable diagnostic capability. This study aims to characterize, by optical fiber Raman-based spectroscopy (OFRS), normal, inflammatory, potentially malignant, benign and malign oral lesions. Raman data were collected by a Holospec f / 1.8 spectrograph (Kayser Optical Systems) coupled to an optical fiber, with a 785nm laser line source and a CCD Detector. The data were pre-processed and vector normalized. The average analysis and standard deviation was performed associated with cluster analysis and compared to the histopalogical results. Samples of described oral pathological processes were used in the study. The OFRS was efficient to characterized oral lesions and normal mucosa, in which biochemical information related to vibrational modes of proteins, lipids, nucleic acids and carbohydrates were observed. The technique (OFRS) is able to demonstrate biochemical information concern different types of oral lesions showing that Raman spectroscopy could be useful for an early and minimal invasive diagnosis. © 2016 SPIE.


Rodrigues P.L.,Institute Pesquisa e Desenvolvimento | De Almeida F.S.,Institute Pesquisa e Desenvolvimento | Motisuke M.,University Federal Of ulo Unifesp | De Sousa E.,University Federal Of ulo Unifesp
Ceramica | Year: 2012

Among calcium phosphate bioceramics, tricalcium phosphate (TCP), in its polymorphic form β, receives many research efforts due to its excellent bioactivity and high resorbability rate making it suitable for the development of temporary orthopedic implants. However, this bioceramic presents a limitation in its processing which is associated with the β-γ phase transition. Then, it is necessary to use sintering additives for obtaining samples with higher densifcation and, consequently, higher mechanical properties. The aim of this work was to evaluate the effect of alumina addition on the physical and mechanical properties of β-tricalcium phosphate. Samples were prepared by uniaxial pressing followed by isostatic pressing. Afterwards, samples were submitted to heat treatments during 2 h at different temperatures (1100, 1200 and 1300 °C/2 h). Even though alumina was not responsible for increasing β-TCP/Al2O3 biocomposite mechanical strength, it acted as a good β phase stabilizer.


PubMed | Institute Pesquisa e Desenvolvimento
Type: Journal Article | Journal: Lasers in medical science | Year: 2010

Low-level laser therapy (LLLT) has been found to produce anti-inflammatory effects in a variety of disorders. Bronchial smooth muscle (BSM) hyperreactivity is associated with increased Ca+2 sensitivity and increased RhoA mRNA expression. In the current study, we investigated if LLLT could reduce BSM contraction force and RhoA mRNA expression in tumor necrosis factor-alpha (TNF-alpha)-induced BSM hyperreactivity. In the study, 112 male Wistar rats were divided randomly into 16 groups, and BSM was harvested and suspended in TNF-alpha baths for 6 and 24 h, respectively. Irradiation with LLLT was performed with a wavelength of 660 nm for 42 s with a dose of 1.3 J/cm2. This LLLT dose was administered once in the 6-h group and twice in the 24-h group. LLLT significantly decreased contraction force in BSM at 6 h (TNF-alpha + LLLT: 11.65+/-1.10 g/100 mg of tissue) (F=3115) and at 24 h (TNF-alpha+LLLT: 14.15+/-1.1 g/100 mg of tissue) (F=3245, p<0.05) after TNF-alpha, respectively, when compared to vehicle-bathed groups (control). LLLT also significantly decreased the expression of RhoA mRNA in BSM segments at 6 h (1.22+/-0.20) (F=2820, p<0.05) and 24 h (2.13+/-0.20) (F=3324, p<0.05) when compared to BSM segments incubated with TNF-alpha without LLLT irradiation. We conclude that LLLT administered with this protocol, reduces RhoA mRNA expression and BSM contraction force in TNF-alpha-induced BSM hyperreactivity.

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