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Marilândia, Brazil

We present the clinical picture Hans Asperger named ‘autistic child psychopathy’ in the context of its discovery, a designation which has persisted to date, and relate that syndrome to Leo Kanner’s early infantile autism, which was discovered at the same time. We discuss the way Asperger’s work has remained neglected by researchers until the 1980s. © 2015, Associacao Universitaria de Pesquisa em Psicopatologia Fundamental. All rights reserved. Source

Peres A.J.A.,Sao Paulo State University | Tomquelski G.V.,Institute Pesquisa | Papa G.,Sao Paulo State University | Vilela R.,Federal University of Mato Grosso do Sul | Martins G.L.M.,State University of Mato Grosso do Sul
Revista Brasileirade Ciencias Agrarias | Year: 2012

The study aimed to evaluate the occurrence of pest and management of cotton genetically modified with the introduction of the bacterium Bacillus thunringiensis compared to conventional cotton in the 'Cerrado' region, installing the field experiment in 2007/2008 in Chapadão do Sul-MS. The experimental design was randomized blocks in a 2 × 3 factorial, with two managements of insecticides (with and without insecticides to control lepidopteran) and 3 modes of use of cultivars: 100% transgenic (NUOPAL), 100% non transgenic (Deltaopal) and interior area with transgenic (80% NUOPAL) with non-transgenic border (20% Deltaopal) with five replications. Evaluations were performed weekly of pest infestation, observing in 15 plants per plot the number of Alabama argillacea, Heliothis virescens and Spodoptera frugiperda. Based on these results it was concluded that: the occurrence of A. argillacea and H. virescens was lower in treated transgenic cultivar. There were no differences between transgenic and conventional farming on the occurrence of S. frugiperda. Source

Ferraz T.M.,State University of Maranhao | Netto A.T.,State University of Norte Fluminense | De Oliveira Reis F.,State University of Maranhao | Pecanha A.L.,State University of Norte Fluminense | And 5 more authors.
Theoretical and Experimental Plant Physiology | Year: 2015

Whole-canopy gas exchange measurement in papaya can provide a scientific basis to optimize irrigation and fruit yield and quality. The objectives of this study were to: (1) verify the relationship between xylem sap flow measured by the heat coefficient method, and whole canopy transpiration in ‘Gran Golden’ papaya (Carica papaya L.), (2) examine the relationship between xylem sap flow determined from calculations based on forcing water flow through a stem section, and whole canopy transpiration, and (3) verify the relationship between transpiration measured in a plant chamber and calculated reference evapotranspiration (ET0). The experiment was conducted in a commercial planting at the Caliman Agrícola SA farm, Sooretama, ES, Brazil in summer and winter. Whole-canopy gas exchange was measured in custom-built, flow-through whole-canopy Mylar® chambers. There was a correlation (r2 = 0.65) between xylem sap flow measured with the heat coefficient (K) method and whole-canopy transpiration rate measured in the chambers. However, sap flow methodology could not convert this correlated response into an accurate estimate of papaya transpiration measured with whole canopy chambers. The sap flow methodologies were linearly correlated with whole canopy transpiration but each would require additional calibration to the crop. ET0 was correlated with whole canopy transpiration in winter but not in summer likely due to stomatal control of transpiration, as a result of the high leaf temperature and ET0 in summer. The concept of sap flow to measure transpiration has value in papaya production but supplementary studies will be necessary to improve the accuracy and estimation of the whole-canopy transpiration in the papaya plant. © 2015, Brazilian Society of Plant Physiology. Source

de Albuquerque D.C.,State University of Rio de Janeiro | Neto J.D.S.,Hospital de Messejana | Bacal F.,University of Sao Paulo | Rohde L.E.P.,Hospital de Clinicas de Porto Alegre | And 48 more authors.
Arquivos Brasileiros de Cardiologia | Year: 2015

Heart failure (HF) is one of the leading causes of hospitalization in adults in Brazil. However, most of the available data is limited to unicenter registries. The BREATHE registry is the first to include a large sample of hospitalized patients with decompensated HF from different regions in Brazil. Objective: Describe the clinical characteristics, treatment and prognosis of hospitalized patients admitted with acute HF. Methods: Observational registry study with longitudinal follow-up. The eligibility criteria included patients older than 18 years with a definitive diagnosis of HF, admitted to public or private hospitals. Assessed outcomes included the causes of decompensation, use of medications, care quality indicators, hemodynamic profile and intrahospital events. Results: A total of 1,263 patients (64 ± 16 years, 60% women) were included from 51 centers from different regions in Brazil. The most common comorbidities were hypertension (70.8%), dyslipidemia (36.7%) and diabetes (34%). Around 40% of the patients had normal left ventricular systolic function and most were admitted with a wet-warm clinical-hemodynamic profile. Vasodilators and intravenous inotropes were used in less than 15% of the studied cohort. Care quality indicators based on hospital discharge recommendations were reached in less than 65% of the patients. Intrahospital mortality affected 12.6% of all patients included. Conclusion: The BREATHE study demonstrated the high intrahospital mortality of patients admitted with acute HF in Brazil, in addition to the low rate of prescription of drugs based on evidence. © 2015, Arquivos Brasileiros de Cardiologia. All rights reserved. Source

Fuchs F.D.,Federal University of Rio Grande do Sul | Scala L.C.N.,Federal University of Mato Grosso | De Mello R.B.,Federal University of Rio Grande do Sul | Mosele F.,Federal University of Rio Grande do Sul | And 25 more authors.
Journal of Hypertension | Year: 2016

Objectives: To compare the blood pressure (BP)-lowering efficacy of a chlorthalidone/amiloride combination pill with losartan, during initial management of stage I hypertension. Methods: In a randomized, double-blind, controlled trial, 655 participants were followed for 18 months in 21 Brazilian academic centers. Trial participants were adult volunteers aged 30-70 years with stage I hypertension (BP 140-159 or 90-99mmHg) following 3 months of a lifestyle intervention. Participants were randomized to 12.5/2.5mg of chlorthalidone/amiloride (N=333) or 50mg of losartan (N=322). If BP remained uncontrolled after 3 months, study medication dose was doubled, and if uncontrolled after 6 months, amlodipine (5 and 10mg) and propranolol (40 and 80mg twice daily) were added as open-label drugs in a progressive fashion. At the end of follow-up, 609 (93%) participants were evaluated. Results: The difference in SBP during 18 months of follow-up was 2.3 (95% confidence interval: 1.2 to 3.3)mmHg favoring chlorthalidone/amiloride. Compared with those randomized to diuretic, more participants allocated to losartan had their initial dose doubled and more of them used add-on antihypertensive medication. Levels of blood glucose, glycosilated hemoglobin, and incidence of diabetes were no different between the two treatment groups. Serum potassium was lower and serum cholesterol was higher in the diuretic arm. Microalbuminuria tended to be higher in patients with diabetes allocated to losartan (28.5±40.4 versus 16.2±26.7mg, P=0.09). Conclusion: Treatment with a combination of chlorthalidone and amiloride compared with losartan yielded a greater reduction in BP. © 2016 Wolters Kluwer Health, Inc. Source

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