Saint-André-lez-Lille, France
Saint-André-lez-Lille, France

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Roumy V.,Lille 2 University of Health and Law | Biabiany M.,Lille 2 University of Health and Law | Hennebelle T.,Lille 2 University of Health and Law | Aliouat E.M.,Lille 2 Institute Pasteur Lille | And 7 more authors.
Journal of Natural Products | Year: 2010

Three compounds were isolated from Acnistus arborescens, a tree commonly used in South and Central America in traditional medicine against several infectious diseases, some of which are caused by fungi. Bioassay-guided fractionation of a MeOH extract of leaves, based on its anti-Pneumocystis carinii activity, led to the isolation of compounds 1-3. Mono- and bidimensional NMR analyses enabled identification of two new withanolides, (20R,22R)-5β,6β-epoxy-4β,12β,20-trihydroxy-1-oxowith-2-en- 24-enolide (1) and (20R,22R)-16β-acetoxy-3β,4β;5β,6β- diepoxy-12β,20-dihydroxy-1-oxowith-24-enolide (2), and withanolide D (3). Antifungal activity on 13 fungi responsible for human infections (five dermatophytes, one nondermatophyte mold, six yeasts, and Pneumocystis carinii) was examined. Cytotoxicity of these compounds was also evaluated in vitro. © 2010 The American Chemical Society and American Society of Pharmacognosy.

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