No J.H.,Institute Pasteur Korea
Acta Tropica | Year: 2016
The current treatments for visceral leishmaniasis are old and toxic with limited routes of administration. The emergence of drug-resistant Leishmania threatens the efficacy of the existing reservoir of antileishmanials, leading to an urgent need to develop new treatments. It is particularly important to review and understand how the current treatments act against Leishmania in order to identify valid drug targets or essential pathways for next-generation antileishmanials. It is equally important to adapt newly emerging biotechnologies to facilitate the current research on the development of novel antileishmanials in an efficient fashion. This review covers the basic background of the current visceral leishmaniasis treatments with an emphasis on the modes of action. It briefly discusses the role of the immune system in aiding the chemotherapy of leishmaniasis, describes potential new antileishmanial drug targets and pathways, and introduces recent progress on the utilization of high-throughput phenotypic screening assays to identify novel antileishmanial compounds. © 2016 Elsevier B.V.
Sweeney G.,Institute Pasteur Korea |
Sweeney G.,York University
Nature Reviews Cardiology | Year: 2010
A wealth of investigations, ranging from clinical and animal model studies to in vitro analyses, have generated great interest in the cardiovascular effects of leptin. Accordingly, many studies have examined the contribution of leptin to cardiac remodeling in heart failure and whether the effects of leptin on metabolism, apoptosis, extracellular matrix remodeling, and hypertrophy could explain the so-called obesity paradox. Furthermore, obesity and hyperleptinemia have often been associated with hypertension, and regulation of sympathetic tone or direct effects of leptin on contributors such as atherosclerosis, endothelial dysfunction, and thrombosis have been documented. Unfortunately, translating basic research studies in vitro, or in animal models, to human physiology has proven difficult. The degree of leptin resistance in obesity is one intriguing issue that must be resolved. Furthermore, the importance of autocrine and paracrine effects of leptin derived from the heart and perivascular adipose tissue must be further studied. Carefully planned and executed research to conclusively establish distinct effects of leptin on the cardiovascular system in normal and diseased states will be essential to harness any therapeutic potential associated with leptin's effects. © 2009 Macmillan Publishers Limited. All rights reserved.
Park J.,Seoul National University |
Oh S.,Seoul National University |
Oh S.,Institute Pasteur Korea |
Park S.B.,Seoul National University
Angewandte Chemie - International Edition | Year: 2012
Target acquired: Fluorescence difference in two-dimensional gel electrophoresis (FITGE) was developed to observe the interactions between proteins and small molecules in an intact cellular environment. FITGE proved effective over conventional methods by successfully identifying the protein target of an anti-proliferative compound in live cells through the differentiation between specific and extensive non-specific binding of photoaffinity probes. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
QURIENT Co. and Institute Pasteur Korea | Date: 2012-04-20
The present invention refers to: a compound having the general formula (I), wherein n is 0, 1, 2 or; m is 0, 1, 2 or 3; o is 0, 1, 2 or 3; W, X, Y and Z are independently selected from CH, N or N-oxide; A is NR
Institute Pasteur Korea, French Institute of Health and Medical Research | Date: 2014-04-28
The present invention relates to 4H-pyrido[1,2-a]pyrimidin-4-one compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.