Sainte-Foy-de-Peyrolières, France
Sainte-Foy-de-Peyrolières, France

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Houvenaeghel G.,Institute Paoli Calmettes CRCM | Houvenaeghel G.,Jean Moulin University Lyon 3 | Cohen M.,Institute Paoli Calmettes CRCM | Bannier M.,Institute Paoli Calmettes CRCM | And 3 more authors.
Bulletin du Cancer | Year: 2013

Micrometastases or sub-micrometastases can be detected by standard histopathological method sometimes associated with immunohistochemistry in lymph nodes, bone marrowand blood. The consequence of these small size involvement may be prognostic and therapeutic. Two factors are necessary to assess this kind of involvement: the rate of involvement of non-sentinel lymph node after axillary lymph node dissection and significative difference of survivals. The rate of involvement of non-sentinel lymph node in case of micrometastases or sub-micrometastases is different from the rate of involvement in case of no lymph node metastases (7 to 8%) or in case of macrometases (30 to 50%). Micrometastase is an important factor to determine the rate of involvement of nonsentinel lymph node, the overall or disease free survival and to assess the need of radiotherapy and chemotherapy. In conclusion, micrometastases and sub-micrometastases have a clinical impact even if complementary axillary lymph node dissection is still discussed.


Houvenaeghel G.,Institute Paoli Calmettes & CRCM | Cohen M.,Institute Paoli Calmettes & CRCM | Bannier M.,Institute Paoli Calmettes & CRCM | Jauffret C.,Institute Paoli Calmettes & CRCM | And 2 more authors.
Bulletin du Cancer | Year: 2016

Surgical de-escalation for invasive Breast cancer treatment A surgical therapeutic de-escalation is going to continue but necessarily has to design in a progressive careful way and especially arranged with the other practitioners and therapeutic methods. These strategies concern as well the surgery of the breast as that of the axillary basin. © 2016 Société Française du Cancer. Publié par Elsevier Masson SAS

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