Progressive multifocal leukoencephalopathy following azathioprine and steroid treatment of pulmonary sarcoid disease [Progressive multifokale Leukenzephalopathie: Schwerwiegende Komplikation einer Immunsuppression]
Franzen D.,Institute |
Franzen D.,Institute Berrenrather |
Franzen D.,Prof Franzen Institute |
Mathys C.,Universitatsklinikum |
And 5 more authors.
Deutsche Medizinische Wochenschrift | Year: 2015
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system following reactivation of the John-Cunningham-Virus (JVC) in an immunocompromised host. This rare condition is characterized by rapid progressing neurologic symptoms often leading to death. In the following, we report on a rapid evolving deterioration of mental status due to PML in an 53-year-old man during treatment of pulmonary sarcoid disease using azathioprine and steroids. In contrast to reported lethal outcomes, our patient experienced a slow recovery of his cognitive impairment and later on of his palsy following termination of immunosuppression. © Georg Thieme Verlag KG Stuttgart New York.
Ismar S.M.H.,University of Auckland |
Chong N.L.,University of Auckland |
Igic B.,University of Auckland |
Igic B.,Australian National University |
And 5 more authors.
New Zealand Journal of Zoology | Year: 2011
Subtle sexual dimorphism and its perception in apparently monomorphic bird species warrant assessment of how birds identify the sex of conspecifics, particularly of prospective mates. Visual sensitivity and its potential co-variation with cryptic sexual dichromatism are still uninvestigated in most avian taxa. Using molecular sexing, reflectance spectrometry and perceptual modelling based on the sequencing of short wavelength visual pigments, we assessed the sex-specificity of coloration and colour perception in the red-tailed tropicbird Phaethon rubricauda. We also measured morphological dimorphism at a previously unstudied breeding locality for this species. Our data are in line with both physical and avian-perceived monochromatism with a potential indication of achromatic sex differences in plumage reflectance. The moderate extent of size dimorphism is consistent with reports from other Pacific breeding populations, and morphological measurements from live specimens in this study are in line with reports on museum specimens from the same sample location. Potential differences between individuals of the same sex in size and coloration warrant the assessment of sexual dimorphism in larger sample sizes of this species. © 2011 The Royal Society of New Zealand.
Toma M.,Institute |
McAlister F.A.,Massachusetts General Hospital |
Coglianese E.E.,Massachusetts General Hospital |
Vidi V.,Brigham and Womens Hospital |
And 4 more authors.
Circulation: Heart Failure | Year: 2012
Background-Low testosterone is an independent predictor of reduced exercise capacity and poor clinical outcomes in patients with heart failure (HF). We sought to determine whether testosterone therapy improves exercise capacity in patients with stable chronic HF. Methods and Results-We searched Medline, Embase, Web of Science, and Cochrane Central Register of Controlled Trials (1980-2010). Eligible studies included randomized controlled trials (RCTs) reporting the effects of testosterone on exercise capacity in patients with HF. Reviewers determined the methodological quality of studies and collected descriptive, quality, and outcome data. Four trials (n-198; men, 84%; mean age, 67 years) were identified that reported the 6-minute walk test (2 RCTs), incremental shuttle walk test (2 RCTs), or peak oxygen consumption (2 RCTs) to assess exercise capacity after up to 52 weeks of treatment. Testosterone therapy was associated with a significant improvement in exercise capacity compared with placebo. The mean increase in the 6-minute walk test, incremental shuttle walk test, and peak oxygen consumption between the testosterone and placebo groups was 54.0 m (95% CI, 43.0-65.0 m), 46.7 m (95% CI, 12.6-80.9 m), and 2.70 mL/kg per min (95% CI, 2.68-2.72 mL/kg per min), respectively. Testosterone therapy was associated with a significant increase in exercise capacity as measured by units of pooled SDs (net effect, 0.52 SD; 95% CI, 0.10-0.94 SD). No significant adverse cardiovascular events were noted. Conclusions-Given the unmet clinical needs, testosterone appears to be a promising therapy to improve functional capacity in patients with HF. Adequately powered RCTs are required to assess the benefits of testosterone in this high-risk population with regard to quality of life, clinical events, and safety. © 2012 American Heart Association, Inc.
Institute | Date: 2010-02-11
Provided is an optical communication device including optical switches. The optical communication device a first multi-mode core disposed on a substrate, the first multi-mode core extending in a first direction and second multi-mode cores disposed on a substrate, the second multi-mode cores parallelly extending in a second direction non-parallel to the first direction to intersect the first multi-mode core. The heaters respectively intersect intersectional regions between the first and second multi-mode cores.
Institute | Date: 2011-01-28
Provided are an apparatus and method for generating random data to be used when masking data to be ciphered. The apparatus for generating random data according to an exemplary embodiment of the present invention is an apparatus for generating a random function using a physically unclonable function (PUF) logic. The apparatus for generating random data logically operates first data and second data using two different types of logic gates, and inverts the logical operation values selected from the logically operated first data and second data every odd sequence and then, inputs them as the second data again, thereby making it possible to form the output data as the random data. The present invention is applied to a data encryption apparatus for encrypting data to prevent a side channel attack.