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Cancino J.L.B.,Instituto Superior Of Ciencias Y Tecnologias Avanzadas Instec | Gual M.R.,Instituto Superior Of Ciencias Y Tecnologias Avanzadas Instec | Marin C.F.C.,Institute Oncologia Y Radiobiologia INOR | Gonzalez J.J.G.,Institute Oncologia Y Radiobiologia INOR | And 2 more authors.
IFMBE Proceedings | Year: 2013

In the present work the development of an in-house irradiator for irradiation at low dose rate (below to 1cGy/min) is described. The knowledge about the biological effects of irradiation at low dose rate is limited. Otherwise the irradiation with beta particles will be also of interest as it's happens in systemic radiotherapy; the biological effects of low dose could be also studied. The cell irradiator consists in an acrylic rectangular box with a tubular capillary array where a radiactive solution will be dispensed inside. The radionuclides used as source could be Y90 or P32. The MCNPX code was used for the calculation of the spatial doses rate profiles in the target (a slice of 3mm in depth of water). The absorbed dose rates for 1MBq of activity are 1.403mGy/h and 3.029mGy/h for P32 and Y90 respectively. The physical features of the irradiation field are appropriated with an useful area or useful irradiation field of about a 80% of total area occupied by the source. © 2013 Springer.

Loo Y.C.,Institute Oncologia y Radiobiologia INOR | Ferrera M.A.,Institute Oncologia y Radiobiologia INOR | Gil R.M.P.,Institute Oncologia y Radiobiologia INOR | Respall M.,Institute Oncologia y Radiobiologia INOR | And 2 more authors.
Revista Cubana de Plantas Medicinales | Year: 2012

Introduction: at present, scientists are resorting more frequently to nature in order to develop drugs against various illnesses such as cancer. The origin of natural products is diverse and their structure is very complex with the capacity of inhibiting through indirect effect the development of tumors by stimulating the defense mechanisms of the body. Objective: to evaluate the indirect antitumor action of plant extracts in Erlich ascitic tumor cells. Methods: a group of 50 NMRI-line mice was interperitoneally pretreated with plant extracts during 5 days. After 48 hours, Erlich ascitic tumor cells were transplanted into the mice. Another control group of mice was pretreated with 0.9 % physiological saline solution; at 48 hours they were also implanted the same tumor cells. The antitumor activity was determined by comparing the control group with the group of mice treated with extracts in terms of tumor implant rejection. The product was considered to be active if it caused 60 % tumor growth inhibition or more. Results: of the evaluated extracts, 5 obtained more than 60 percent of survival in animals at one of the tested doses, with no signs of tumor after observation during 30 days. It proved that these extracts were active. Conclusions: it was proved that these 5 extracts could be potential products in stimulating immune response, so they should be further studied in the future.

Napoles Morales M.,Institute Oncologia y Radiobiologia INOR | Diaz Ortega I.,Institute Oncologia y Radiobiologia INOR | Silveira Pablos M.,Institute Oncologia y Radiobiologia INOR | Aguilar Fabre K.,Institute Oncologia y Radiobiologia INOR | And 3 more authors.
Revista Cubana de Obstetricia y Ginecologia | Year: 2010

This is the case of a female patient presenting with Rokitansky syndrome diagnosed from 1984, evaluated in the National Institute of Oncology and Radiobiology (NIOR) by presence of pelvic tumor lesion became a wall fibroleiomyoma.

Hernandez M.A.R.,Institute Oncologia y Radiobiologia INOR | Menendez M.H.,Institute Oncologia y Radiobiologia INOR | de Oro F.O.A.V.,Institute Oncologia y Radiobiologia INOR | Pablos M.S.,Institute Oncologia y Radiobiologia INOR | And 2 more authors.
Revista Cubana de Obstetricia y Ginecologia | Year: 2010

Cervix cancer (UCC) is considered a sexually transmitted disease due to factors involved in its appearance and development and this infection is recognized as the main etiological agent of this entity. In Cuba this type of tumor is placed in 2nd category in incidence and in 4th place in mortality among the malignant disease affecting the female sex. The objective of present study is to determine the types of human virus papiloma (HVP) present in samples of cervix tumors in Cuban women, as well as to describe the behavior of different risk factors associated with this disease. Forty five samples of cervix cancer were analyzed and the presence of 20 types of HVP was determined by polymerase chain reaction with specific primers founding in them a 91,1% of positivity. Genotype 16 was the more prevalent, followed by the 18, 45, 31, 39, 51, 56, 59, PAP23A. The low risk type 6 and 11 weren't founded in samples. Promiscuity was the more interesting risk factor in our study. Knowledge of the viral types present in cervix cancer in our patients is very important when we approach the development and the use of prophylactic and therapeutical vaccines.

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