ITV Institute of Textile Technology and Process Engineering

Denkendorf, Germany

ITV Institute of Textile Technology and Process Engineering

Denkendorf, Germany
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Hartmann H.,University of Tübingen | Hossfeld S.,University of Tübingen | Schlosshauer B.,University of Tübingen | Mittnacht U.,University of Tübingen | And 6 more authors.
Journal of Controlled Release | Year: 2013

Binding, stabilizing and promoting cellular uptake of siRNA are all critical efforts in creating matrices for the localized delivery of siRNA molecules to target cells. In this study, we describe the generation of chitosan imidazole/siRNA nanoplexes (NPs) embedded in nano scope polyelectrolyte multilayers (PEMs) composed of hyaluronic acid and chitosan for sustained and localized drug delivery. Regular PEM build-up, successful integration of NPs and controlled release under physiological conditions were shown. Biological efficacy was evaluated in neuronal cell culture concerning cell adhesion, viability, NPs uptake and gene silencing. The additionally shown biological functionalization of neuronal implants possesses potential for future applications in the field of regenerative medicine and treatment of spinal cord injuries. © 2013 Elsevier B.V.

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