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Chen H.-G.,Jiangxi Provincial Institute of Parasitic Diseases | Xie S.-Y.,Jiangxi Provincial Institute of Parasitic Diseases | Zeng X.-J.,Jiangxi Provincial Institute of Parasitic Diseases | Huang X.-B.,Institute of Schistosomiasis Control | And 4 more authors.
Chinese Journal of Schistosomiasis Control | Year: 2011

This paper reviewed the current endemic features and situation of schistosomiasis in lake and marshland regions in China, and discussed the comprehensive control strategy for schistosomiasis with emphasis on infectious sources control, including its theoretical basis, the reality conditions of implementation and technical composition, and also introduced the effectiveness of the pilot trails and their large-scale application as well as several issues in the implementation. The aim of the review is to accelerate the process of schistosomiasis control in lake and marshland regions and promote the achievement of mid- and long-term goals in national schistosomiasis control program. Source


Xia X.,Wuhan University | Zhu H.-P.,Capital Medical University | Yu C.-H.,Wuhan University | Xu X.-J.,Institute of Schistosomiasis Control | And 2 more authors.
International Journal of Environmental Research and Public Health | Year: 2013

A Bayesian inference model was introduced to estimate community prevalence of Schistosomiasis japonica infection based on the data of a large-scale survey of Schistosomiasis japonica in the lake region in Hubei Province. A multistage cluster random sampling approach was applied to the endemic villages in the lake regions of Hubei Province in 2011. IHA test and Kato-Katz test were applied for the detection of the S. japonica infection in the sampled population. Expert knowledge on sensitivities and specificities of IHA test and Kato-Katz test were collected based on a two-round interview. Prevalence of S. japonica infection was estimated by a Bayesian hierarchical model in two different situations. In Situation 1, Bayesian estimation used both IHA test data and Kato-Katz test data to estimate the prevalence of S. japonica. In Situation 2, only IHA test data was used for Bayesian estimation. Finally 14 cities and 46 villages from the lake regions of Hubei Province including 50,980 residents were sampled. Sensitivity and specificity for IHA test ranged from 80% to 90% and 70% to 80%, respectively. For the Kato-Katz test, sensitivity and specificity were from 20% to 70% and 90% to 100%, respectively. Similar estimated prevalence was obtained in the two situations. Estimated prevalence among sampled villages was almost below 13% in both situations and varied from 0.95% to 12.26% when only using data from the IHA test. The study indicated that it is feasible to apply IHA test only combining with Bayesian method to estimate the prevalence of S. japonica infection in large-scale surveys. © 2013 by the authors; licensee MDPI, Basel, Switzerland. Source


Yang R.,Wuhan University | Zhu Z.-H.,Wuhan University | Huang X.-B.,Institute of Schistosomiasis Control | Tan X.-D.,Wuhan University
Chinese Journal of Schistosomiasis Control | Year: 2012

Objective: To evaluate the performance of small Oncomelania snail control projects in Hubei Province in 2009 and 2010, so as to explore the best snail control project in different areas. Methods: The expense-effect, expense-efficiency and cost-utility analyses were carried out to analyze the small snail control projects with reference to the relevant schistosomiasis japonica prevention and control index system. Results: The coverage rate of snail control was 40.15%, the decrease rate of the snail areas was 32.86%, the unit cost for the snail control was 0.39 Yuan/m2, the cost of reducing 1% of the snail area was 67.34 ten thousand Yuan, the total benefit was 15 554.14 ten thousand Yuan, the ratio of cost to benefit was 7.03, the net benefit was 13 341.44 ten thousand Yuan, and the ratio of cost to net benefit was 6.03, and the investment ratio was 1:2.11 in the 183 small snail control projects. Conclusion: There is an obvious and respectable short-period effect of the small snail control projects. Source


Li S.-Z.,National Institute of Parasitic Diseases | Qian Y.-J.,National Institute of Parasitic Diseases | Yang K.,Jiangsu Institute of Parasitic Diseases | Wang Q.,National Institute of Parasitic Diseases | And 6 more authors.
Geospatial Health | Year: 2012

Schistosomiasis is one of the major public health problems in the People's Republic of China (and elsewhere), seriously threatening health as well as social and economic development. An integrated control strategy, emphasising transmission control but also aimed at reducing greenhouse gases, was carried out in Jiangling county, Hubei province from 2007 to 2009. Three villages were chosen for a pilot study involving removal of cattle from neighbouring, snail-infested grasslands, improving sanitation and construction of units for household biogas production in addition to routine control measures. Both prevalence and intensity of infection in the snails in the neighbourhood were greatly reduced after two years of implementation, while the prevalence of schistosomiasis in humans in the three villages had been reduced by 29%, 34% and 24%, respectively. The removal of cattle and construction of biogas production units had an additional positive effect in that the annual, average emission of greenhouse gases such as methane (CH 4) and carbon dioxide (CO 2) were reduced by an estimated 7.8 and 80.2 tons, respectively. Source


Lei J.-H.,Huazhong University of Science and Technology | Su B.-T.,Huazhong University of Science and Technology | Xu H.,Huazhong University of Science and Technology | Shen J.-L.,Anhui Medical University | And 5 more authors.
American Journal of Tropical Medicine and Hygiene | Year: 2011

We have developed a novel egg yolk antibody (IgY)-coated magnetic beads antigen-capture immunoassay for detection of a circulating antigen of Schistosoma japonicum in serum samples of patients in schistosomiasis-endemic areas of China. This IgY-based immunomagnetic bead enzyme-linked immunosorbent assay (IgY-IMB-ELISA) uses polyclonal IgY-coated magnetic beads as a capture antibody, and a monoclonal IgG as a detection antibody. The sensitivity of the magnetic immunoassay was 100% (40 of 40) in cases of acute infection and 91.5% (107 of 117) in chronic cases of schistosomiasis, and no positive reaction was found in 0 of 49 healthy persons. Cross-reactivity was 3.3% (1 of 33) with clonorchiasis and 0% (0 of 20) with paragonimiasis. There was a significant correlation between ELISA absorbance value and egg count (eggs per gram feces) and a correlation coefficient of 0.88 in a small sample of 14 patients. The results demonstrated that the IgY-IMB-ELISA is a sensitive and specific assay for detection of human schistosomiasis japonica. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene. Source

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