Institute of Rural Health

Lublin, Poland

Institute of Rural Health

Lublin, Poland
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Receive press releases from MedAware Systems, Inc.: By Email Broomfield, CO, May 03, 2017 --( Dr. Piland is a recognized authority in healthcare economics and research, Dr. Piland is Research Professor, Emeritus, Institute of Rural Health, Idaho State University. He also served as Director of the Institute for thirteen years. Dr. Piland brings over forty-five years of experience in health services research, health care financing, and healthcare economics. Prior to his tenure at Idaho State University, he served as Director of the Medical Group Management Center for Research; was founding director of the Lovelace Medical Foundation’s Institute for Health and Population Research. He also served as Health Economist and Assistant Manager of Health Services Research at Stanford Research Institute (now SRI International). Dr. Piland held senior administrative and faculty positions at the Colorado Health Institute; the University of Colorado School of Medicine; the University of New Mexico School of Medicine; the University of Denver; the San Diego Veterans Administration Medical Center; and the Veterans Medical Research Foundation. He served as Principal Investigator on more than 30 major health services research projects and published over 100 scientific and health policy related articles and book chapters and has coauthored four books. He holds numerous awards, including the Indian Health Service (USDHHS) Director Award; Professional Leadership Award from the American Lung Association; Scientific Research Award from the Lovelace Medical Foundation; and a United States Public Health Service Training Fellowship, among others. “We are honored to have Dr. Piland join our Scientific Advisory Board” said Founder and Chief Science Officer, Dr. Zung Vu Tran. He adds, “Dr. Piland brings a wealth of knowledge and experience in healthcare economics and research that will add critical economic data components that are highly valuable to our customers.” About MedAware Systems, Inc. MedAware Systems, Inc. disrupts the health informatics industry by forever changing the way Pharma and medical device companies, physicians, payers and consumers derive usable evidence from published clinical trials research. The Company’s Science of Health Informatics (SOHInfo™) is a Scientific-Data-as-a-Service (SDaaS™) solving the problem of making the vast and chaotic body of human clinical trials research instantly available and indispensable in understanding medical treatment safety and efficacy. SOHInfo organizes and standardizes data from all human clinical trials and provides immediate and actionable information on evidence-based medical treatments and outcomes. Broomfield, CO, May 03, 2017 --( PR.com )-- MedAware Systems, Inc. announced today that Dr. Neill Piland is joining the Company’s Scientific Advisory Board.Dr. Piland is a recognized authority in healthcare economics and research, Dr. Piland is Research Professor, Emeritus, Institute of Rural Health, Idaho State University. He also served as Director of the Institute for thirteen years.Dr. Piland brings over forty-five years of experience in health services research, health care financing, and healthcare economics. Prior to his tenure at Idaho State University, he served as Director of the Medical Group Management Center for Research; was founding director of the Lovelace Medical Foundation’s Institute for Health and Population Research. He also served as Health Economist and Assistant Manager of Health Services Research at Stanford Research Institute (now SRI International). Dr. Piland held senior administrative and faculty positions at the Colorado Health Institute; the University of Colorado School of Medicine; the University of New Mexico School of Medicine; the University of Denver; the San Diego Veterans Administration Medical Center; and the Veterans Medical Research Foundation.He served as Principal Investigator on more than 30 major health services research projects and published over 100 scientific and health policy related articles and book chapters and has coauthored four books. He holds numerous awards, including the Indian Health Service (USDHHS) Director Award; Professional Leadership Award from the American Lung Association; Scientific Research Award from the Lovelace Medical Foundation; and a United States Public Health Service Training Fellowship, among others.“We are honored to have Dr. Piland join our Scientific Advisory Board” said Founder and Chief Science Officer, Dr. Zung Vu Tran. He adds, “Dr. Piland brings a wealth of knowledge and experience in healthcare economics and research that will add critical economic data components that are highly valuable to our customers.”About MedAware Systems, Inc.MedAware Systems, Inc. disrupts the health informatics industry by forever changing the way Pharma and medical device companies, physicians, payers and consumers derive usable evidence from published clinical trials research. The Company’s Science of Health Informatics (SOHInfo™) is a Scientific-Data-as-a-Service (SDaaS™) solving the problem of making the vast and chaotic body of human clinical trials research instantly available and indispensable in understanding medical treatment safety and efficacy. SOHInfo organizes and standardizes data from all human clinical trials and provides immediate and actionable information on evidence-based medical treatments and outcomes. Click here to view the list of recent Press Releases from MedAware Systems, Inc.


Luszczki J.J.,Institute of Rural Health | Luszczki J.J.,Medical University of Lublin | Florek-Luszczki M.,Institute of Rural Health
Pharmacological Reports | Year: 2012

Background: The aim of the study was to determine the type of interaction between pregabalin (a 3rd -generation antiepileptic drug) and WIN 55,212-2 mesylate (WIN - a highly potent non-selective cannabinoid CB1 and CB2 receptor agonist) administered in combination at a fixed ratio of 1:1, in the acute thermal pain model (hot-plate test) in mice. Methods: Linear regression analysis was used to evaluate the dose-response relationships between logarithms of drug doses and their resultant maximum possible antinociceptive effects in the mouse hot-plate test. From linear equations, doses were calculated that increased the antinociceptive effect by 30% (ED30 values) for pregabalin, WIN, and their combination. The type of interaction between pregabalin and WIN was assessed using the isobolographic analysis. Results: Results indicated that both compounds produced a definite antinociceptive effect, and the experimentally-derived ED30 values for pregabalin and WIN, when applied alone, were 29.4 mg/kg and 10.5 mg/kg, respectively.With isobolography, the experimentally derived ED30 mix value for the fixed ratio combination of 1:1 was 5.7 mg/kg, and differed significantly from the theoretically calculated ED30 add value of 19.95 mg/kg (p < 0.01), indicating synergistic interaction between pregabalin and WIN in the hot-plate test in mice. Conclusions: Isobolographic analysis demonstrated that the combination of WIN with pregabalin at a fixed ratio of 1:1 exerted synergistic interaction in the mouse model of acute thermal pain. If the results from this study could be adapted to clinical settings, the combination of WIN with pregabalin might be beneficial for pain relief in humans. Copyright © 2011 by Institute of Pharmacology Polish Academy of Sciences.


Florek-Luszczki M.,Institute of Rural Health | Wlaz A.,Medical University of Lublin | Luszczki J.J.,Medical University of Lublin | Luszczki J.J.,Institute of Rural Health
European Journal of Pharmacology | Year: 2014

The aim of the presented study was to characterize the anticonvulsant effects of levetiracetam in combination with various antiepileptic drugs (carbamazepine, phenytoin, topiramate and vigabatrin) in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes; type II isobolographic analysis was used to characterize the consequent anticonvulsant interactions between the various drug combinations for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. With type II isobolographic analysis, the combinations of levetiracetam with carbamazepine and phenytoin for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.01) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive. Levetiracetam combined with topiramate and vigabatrin for the fixed-ratio of 1:10 exerted supra-additive interaction (P<0.05), and simultaneously, the two-drug combinations for the fixed-ratios of 1:1, 1:2 and 1:5 produced additive interaction in the mouse 6 Hz psychomotor seizure model. The combinations of levetiracetam with carbamazepine and phenytoin for the fixed-ratios of 1:5 and 1:10, as well as the combinations of levetiracetam with topiramate and vigabatrin for the fixed-ratio of 1:10 appear to be particularly favorable combinations exerting supra-additive interaction in the mouse 6 Hz psychomotor seizure model. Finally, it may be concluded that because of the synergistic interactions between levetiracetam and carbamazepine, phenytoin, topiramate and vigabatrin, the combinations might be useful in clinical practice. © 2013 Elsevier B.V.


Blaszczyk B.,School of Economics and Law in Kielce | Lason W.,Polish Academy of Sciences | Czuczwar S.J.,Medical University of Lublin | Czuczwar S.J.,Institute of Rural Health
Pharmacological Reports | Year: 2015

This paper summarizes current views on clinical manifestation, pathogenesis, prognosis and management of antiepileptic drug (AED)-induced adverse skin reactions. Cochrane Central Register of Controlled Trials, MEDLINE (PubMed) and ISI Web of Knowledge were searched. The recent classification, among drug-induced skin injuries, points to Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), acute generalized exanthematous pustulosis and hypersensitivity syndrome (HSS), which may be also recognized as a drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS). The use of aromatic AEDs, e.g. phenytoin, carbamazepine, oxcarbazepine, phenobarbital, primidone, zonisamide, and lamotrigine is more frequently associated with cutaneous eruption and other signs or symptoms of drug hypersensitivity. There is a high degree of cross-reactivity (40-80%) in patients with hypersensitivity or allergic reactions to AEDs. Pharmacogenetic variations in drug biotransformation may also play a role in inducing these undesired effects. It is suggested that avoidance of specific AEDs in populations at special risk, cautious dose titration and careful monitoring of clinical response and, if applicable, laboratory parameters can minimize the serious consequences of idiosyncratic reactions. © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.


Wasinski B.,National Veterinary Research Institute | Dutkiewicz J.,Institute of Rural Health
Annals of Agricultural and Environmental Medicine | Year: 2013

Leptospirosis is a widespread although recently neglected zoonosis recognized worldwide. The disease seems to be underestimated, especially in countries located in the temperate climatic zone. The presented article concerns the main characteristics of leptospirosis and describes formerly known and recently observed environmental, occupational and recreational risk factors significant in the spreading and pathogenesis of the disease. The aspects of epidemiology significant in the temperate climatic zone are emphasized. The majority of cited articles present cases of the disease reported from Europe or North America. Climatic changes (warming) and extreme weather events such as foods are potential risk factors of leptospirosis. Also, some socio-economic phenomena, such as the intensive migration of people resulting in the transfer of the infections acquired in tropical countries, or worsening of economic status in the cities, increase the probability of disease. Apart from the danger connected with rodents, which are the main vectors of leptospires, occurrence of the disease in dogs and cats can generate a higher risk of infection for humans. Infections may also be acquired during various types of agricultural work and during recreational activities, such as swimming. The results of recent investigations show that ticks are also potential vectors of leptospires. The more frequent emergence of leptospirosis in countries located in the temperate climatic zone emphasize the need to verify knowledge related to the risk of its appearance, and to consider this disease during diagnostic processes.


Brzezinski K.,Institute of Rural Health
Wspolczesna Onkologia | Year: 2012

Chemotherapy-induced peripheral neuropathy (CIPN) is a toxic neuropathy, a syndrome consisting of highly distressing symptoms of various degrees of severity. It includes numbness of distal extremities, long-term touch, heat, and cold dysaesthesia and, in more severe cases, motor impairment affecting daily functioning. Each form of the syndrome may be accompanied by symptoms of neuropathic stinging, burning, and tingling pain. In the case of most chemotherapeutic agents, the incidence and severity of CIPN are dependent on the cumulative dose of the drug. The syndrome described is caused by damage to the axons and/or cells of the peripheral nervous system. Chemotherapeutic agents have distinct mechanisms of action in both neoplastic tissue and the peripheral nervous system; therefore, CIPN should not be regarded as a homogeneous disease entity. The present article is an attempt to systematize the knowledge about the toxic effects of chemotherapy on the peripheral nervous system.


Epidemiological population studies indicate that the nutrition of women at reproductive age and during pregnancy exerts an effect not only on the term of delivery, development of the foetus and birth weight, but also on the susceptibility of off spring to civilization diseases in adulthood, according to the hypothesis of Developmental Origin of Heath and Diseases (DOHaD). The author analyses the results of epidemiological studies conducted in 2011 in a randomly selected representative population of 6,000 Polish adolescents aged 14-24 (of the total of adolescents, a population of females was selected for analysis), and the results of foetal period health monitoring of mother and child (PRAMS) which has been conducted in Poland since 2009 in the population of mothers and their newborn babies staying after delivery in all hospitals in Poland. Analysis of these two population studies indicates that a high percentage of Polish women at reproductive age are dieting. At the same time, confirmation of the fact of becoming pregnant occurs between weeks 5-8 after conception. This shows that until that time, the foetuses of women on the Apple weight loss diet develop conditions of nutritional deficits which, according to the DOHaD hypothesis, may result in epigenetic changes which increase the susceptibility of off spring in adulthood to civilization diseases: cardiovascular disorders, type 2 diabetes or metabolic syndrome. This hypothesis is confirmed by the high percentages of newborns in Poland born with low birth weight or prematurely born, as well as the fact that the percentage of anemia in pregnant Polish women is twice as high as in other developed countries. Simultaneously, a large number of babies are born with excessive birth weight (macrosomia). The author considers that in the countries of East-Central Europe the phenomenon observed is characteristic at present of the developing countries of the Third World, called the 'double burden of malnutrition'. This situation creates risk of the occurrence of an epidemics of civilization diseases in our part of Europe of a greater intensity than in other developed countries. The author postulates that the educational actions in the area of health promotion in the control of overweight and obesity should be differentiated according to gender and age. The activities to-date in the field of overweight and obesity control in Poland has led to an increase in the number of girls and young women suffering from nutritional disorders as a result of too drastic methods of losing weight. According to the DOHaD hypothesis applied, this may have tragic results for their off spring and for future generations.


Szymanska J.,Medical University of Lublin | Sitkowska J.,Institute of Rural Health
Future Microbiology | Year: 2013

Aim: The study aimed to determine qualitative and quantitative contamination of dental unit reservoir water with aerobic and facultative anaerobic bacteria, with regards to health risk to dental staff and patients. Materials & methods: The study material included water samples from 107 unit reservoirs. Conventional microbiological methods were used. The isolated bacteria were divided into three groups according to pathogenic mechanisms. Results: Dental unit water contamination was widespread. The isolated bacteria average concentration was 1.1 × 105 CFU/ml, with Ralstonia pickettii as the prevailing species (49.33%). The total potentially pathogenic bacteria were 54.54% of all the isolated bacteria. Bacteria causing infectious and invasive diseases constituted over one-half of this group, while allergizing and immunotoxic bacteria occurred in smaller quantities. Conclusion: The presence of over 50% potentially pathogenic microorganisms among the isolated bacteria and their very high concentrations call for the daily use of effective methods to reduce dental unit water contamination and health risk. © 2013 Future Medicine Ltd.


Solecki L.,Institute of Rural Health
Annals of Agricultural and Environmental Medicine | Year: 2012

The objective of the study was to recognize and evaluate the annual exposure of private farmers to whole body mechanical vibration on selected family farms of mixed production profile (plant-animal). The scope of study covered the carrying out of time schedules of agricultural activities, and measurements of the frequency weighted vibration acceleration (m/s2), expressed as effective values (r.m.s.) for each of three spatial directions on the seat surface within the period of the whole year. The basic vibration parameter was vibration dose (d). The following values were determined: total monthly vibration dose, mean equivalent daily vibration dose, and mean equivalent daily vibration acceleration. The highest values of the total monthly vibration dose (d) were observed in April and August (55.3-56.7 m2/s4. h). The mean equivalent of daily vibration acceleration showed the highest values in four months of the year: April, August, September and October (0.49-0.60 m/s2); the average value of this parameter for the whole year reached the level of 0.44 m/s2 - below the standard. Due to the occurrence in agricultural vehicles of mechanical shocks (mean values of maximum vibration acceleration: 0.82-1.00 m/s2; exceeding the standard), and exceeding of the daily exposure action value, proper steps should be undertaken with respect to the protection of private farmers against risk resulting from exposure to mechanical vibration while performing work activities.


Zukiewicz-Sobczak W.A.,Institute of Rural Health
Postepy Dermatologii i Alergologii | Year: 2013

Allergic diseases such as allergic rhinitis, pharyngitis, laryngitis, asthma, airborne dermatitis, or allergic conjunctivitis, can be caused or aggravated by components of bioaerosol from natural environment or from indoor environment in enclosed spaces, workplaces and homes. The main components of bioaerosol are fungi and their metabolites, which are common in the environment.

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