Serbetci T.,R.A.U.M. |
Genes C.,R.A.U.M. |
Depauw S.,Lille 2 University of Health and Law |
Depauw S.,Institute Of Recherches Sur Le Cancer Of Lille Ircl |
And 8 more authors.
European Journal of Medicinal Chemistry | Year: 2010
Benzo[c][1,7] and [1,8]phenanthroline substituted by dialkylaminoalkyl side chains at position C2 and C1, respectively, were synthesized and their biological activity evaluated. These compounds displayed more potent cytotoxicity toward L1210 cells than the parent unsubstituted compounds, associated with strong DNA interaction. The moderate TopoI inhibitory activity induced by the novel compounds suggests that other cellular targets should be responsible for the antiproliferative activity. © 2010 Elsevier Masson SAS. All rights reserved.