Vo D.D.,CNRS Chemistry Institute of Rennes |
Gautier F.,University of Nantes |
Gautier F.,Institute Of Cancerologie Of Louest |
Gautier F.,Biogenouest Institute Of Recherche Therapeutique Of Luniversite Of Nantes |
And 5 more authors.
We describe here the synthesis of a series of new molecules containing phenol and heteroaromatic moieties, compounds, which have been evaluated for their ability to inhibit Bax/Bcl-xL interactions in BRET assays. Among them, a triazole derivative 13, exhibit a very promising activity, being more potent than the reference compounds acylpyrogallol 1 and ABT 737. These preliminary results demonstrate that derivatives of this family can be attractive to develop new molecules with potent anticancer activity. © 2013 Elsevier Ltd. All rights reserved. Source