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Vo D.D.,CNRS Chemistry Institute of Rennes | Gautier F.,University of Nantes | Gautier F.,Institute Of Cancerologie Of Louest | Gautier F.,Biogenouest Institute Of Recherche Therapeutique Of Luniversite Of Nantes | And 5 more authors.
Tetrahedron | Year: 2014

We describe here the synthesis of a series of new molecules containing phenol and heteroaromatic moieties, compounds, which have been evaluated for their ability to inhibit Bax/Bcl-xL interactions in BRET assays. Among them, a triazole derivative 13, exhibit a very promising activity, being more potent than the reference compounds acylpyrogallol 1 and ABT 737. These preliminary results demonstrate that derivatives of this family can be attractive to develop new molecules with potent anticancer activity. © 2013 Elsevier Ltd. All rights reserved. Source

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