Festa C.,University of Naples Federico II |
De Marino S.,University of Naples Federico II |
D'Auria M.V.,University of Naples Federico II |
Monti M.C.,University of Salerno |
And 4 more authors.
Tetrahedron | Year: 2012
DCCC chromatography followed by HPLC purification on the polar extract of marine sponge Theonella swinhoei resulted in the isolation of five new cyclopeptides, perthamides G-K. The new structures, featuring unprecedented amino acid units, were determined by interpretation of extensive spectroscopic and spectrometric data (MS, 1H and 13C NMR, COSY, HSQC, HMBC, and ROESY). Pharmacological analysis demonstrated that these natural cyclopeptides are endowed with anti-inflammatory potential as assessed by their ability to reduce carrageenan-induced mouse paw oedema. © 2011 Elsevier Inc. All rights reserved.