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Alcaide A.,Institute Of Quimica Avanada Of Catalonia Iqac Csic | Llebaria A.,Institute Of Quimica Avanada Of Catalonia Iqac Csic
Tetrahedron Letters | Year: 2012

A practical and versatile method for the synthesis of 1-thio- phytosphingolipid analogs through regioselective nucleophilic ring-opening reactions of phytosphingosine aziridine derivatives with thiols is described. The reactions were carried out with N-acylaziridines and a variety of thiol compounds. Microwave irradiation highly improved the yield of the ring-opening reaction and the intermediate N-acyl adducts were converted into 1-S-phytosphingolipid analogs, such as phytoceramide and phytosphingosine derivatives. © 2012 Elsevier Ltd. All rights reserved. Source

Gangoiti P.,University of the Basque Country | Camacho L.,Institute Of Quimica Avanada Of Catalonia Iqac Csic | Arana L.,University of the Basque Country | Ouro A.,University of the Basque Country | And 8 more authors.
Progress in Lipid Research | Year: 2010

Simple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial regulators of cell functions. In particular, they play important roles in the regulation of angiogenesis, apoptosis, cell proliferation, differentiation, migration, and inflammation. Decoding the mechanisms by which these cellular functions are regulated requires detailed understanding of the signaling pathways that are implicated in these processes. Most importantly, the development of inhibitors of the enzymes involved in their metabolism may be crucial for establishing new therapeutic strategies for treatment of disease. © 2010 Elsevier Ltd. All rights reserved. Source

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