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Cvjetkovic I.H.,Public Health Institute of Vojvodina
HealthMED | Year: 2012

Introduction: Erysipelas is acute dermoepidermitis most often caused by group A beta-haemolytic streptococci. The disease is more common in females, older age, immunocompromised persons and those suffering from chronic diseases. Goal: to determine distribution of erysipelas patients related to sex and age, predisposing factors, clinical characteristics related to sex and duration of hospitalization. Methods: Retrospective analysis of medical histories of 86 erysipelas patients (54 females, 32 males) hospitalized at the Clinic for Infectious Diseases, Clinical centre of Vojvodina during 3-years period was made. In the studied patients the following parameters were monitored: demographic data (sex, age), predisposing factors for erysipelas, clinical characteristics of disease, duration of hospitalization, type and duration of used antibiotic therapy and outcome of disease. Statistical analysis was performed by using χ2-test and t-test. Results: Most of involved female patients were 70 to 79 years old; the majority of males were 50 to 59 years old. The most common localization of erysipelas was lower leg, both in females (68.6%) and males (81.3%). The most common clinical form of erysipelas in both sexes was classic form (51.8% of females, 46.9% of males). Most common clinical characteristics in both sexes were fever, general complaints and local signs of inflammation, leucocytosis with polynucleosis, elevated sedimentation rate and elevated serum fibrinogen. When it comes to clinical manifestations of erysipelas, significant differences in relation to sex were not found. There was a statistically significant difference in terms of average values of ALT (t=3,0323, p<0,05), and average values of AST (t=2,0244, p<0,05) between genders, in favour of males. Average duration of antibiotic treatement was 15 days in females and 14 days in males. Average duration of hospitalization was 14 days in females vs. 13 days in males. Conclusion: In our study erysipelas occurred more often in females. The majority of females with erysipelas belonged to age group of 70-79 years, but males most commonly suffered from erysipelas at age of 50-59 years. The most significant predisposing factors in both sexes were diabetes mellitus, chronic heart and blood vessel diseases, obesity, and alcohol abuse among males. Erysipelas was clinically expressed most commonly with fever, general complaints, local signs of inflammation and leucocytosis. There was statistically significant increase of alanine- and aspartate-aminotranspherase among males. The outcome of disease was favourable and complications were rare. There was no fatal outcome among studied erysipelas patients. A notable number of relapsing erysipelas cases was recorded.

Srdjenovic B.,University of Novi Sad | Mrdjanovic J.,Oncology Institute of Vojvodina | Galovic A.J.,Public Health Institute of Vojvodina | Kladar N.,University of Novi Sad | And 3 more authors.
Central European Journal of Biology | Year: 2014

The effect of ELF-EMF on DNA through changes in antioxidative enzyme activities has not been sufficiently explored yet. The aim of this study was to determine ELF-EMF effect on antioxidative enzymes in cancer cell line and genotoxic potential on normal human lymphocytes. K562 cells were exposed to 50 Hz ELF-EMF (40 μT, 100 μT; 3 h, 24 h) and spectrophotometric determination of lipid peroxidation and antioxidative enzyme activities was conducted. Genotoxicity of ELF-EMF (50 Hz, 100 μT) was investigated by cytokinesis-block micronucleus assay in a normal human lymphocytes (exposure 24 h and 48 h). Results demonstrated that ELF-EMF did not alter the process of lipid peroxidation and superoxide dismutase activity. Catalase activity was increased only after application of 100 μT EMF for 24 h. Glutathione-S-transferase and -reductase activities were increased. Treatment with 100 μT ELF-EMF (24 h, 48 h) significantly reduced micronuclei incidence, while cell proliferation was significantly increased. Results indicate that 50 Hz ELF-EMF (40 μT, 100 μT) are week stressors which alone cannot generate enough ROS to induce process of lipid peroxidation in cancer cell line but strong enough to induce response of antioxidative system. Furthermore, 100 μT ELF-EMF in human lymphocytes did not exhibit genotoxic potential during 24 h and 48 h treatment, but stimulated cell proliferation. © 2014 Versita Warsaw and Springer-Verlag Wien.

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