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Tasic-Otasevic S.A.,University of Niš | Tasic-Otasevic S.A.,Institute of Public health Nis | Gabrielli S.V.,University of Rome La Sapienza | Genchi C.,University of Milan
Veterinary Parasitology | Year: 2015

Dirofilaria immitis and Dirofilaria repens infections are mosquito-borne diseases, mainly of dogs. Both parasites are zoonotic, and they sometimes cause serious infections in humans. The aim of this short review was to examine the situation in the Balkan Peninsula, from where it is not always easy to obtain suitable data, often reported in journals and other publications difficult to be retrieved and with poor or no visibility. The review included data from international and regional literature, doctoral theses, and conference proceedings. © 2015 Elsevier B.V.


Kocic B.,University of Niš | Kocic B.,Institute of Public Health Nis | Filipovic S.,University of Niš | Petrovic B.,University of Niš | And 5 more authors.
Journal of B.U.ON. | Year: 2010

Purpose: In view of the crucial importance of early detection and diagnosis of breast cancer for subsequent treatment and prognosis, the aim of this study was to identify clinical and biological characteristics of breast cancer at the time ofdiagnosis. Methods: The study enrolled 449 breast cancer patients in Clinical Centre Nis. Results were analyzed using Student's t-test for paired and unpaired samples, chi-square test, Mantel-Haenszel test and Fisher's test of exact probability. Results: The average patient age was 56.2±12 years (range 23-85). Seventy-three percent of the affected women were postmenopausal and 8.3% below 40 years of age. Operable disease was identified in 78% of the cases, and metastaticin 3.6%. TNM clinical stage IIA was identified in 27.6% of the patients, T2 in 49.2% and Tis in 0.9%. Almost 44% had negative axillary lymph nodes. Most common monopolization of metastatic disease was the liver and the supraclaviculor lymph nodes, and combined localization was the liver and bones. Histologic and nuclear grades 2 and ductal carcinoma were most common. Estrogen receptor positive (ER+) status was 3-fold higher than ER negative (ER-) status. Human epidermal growth factor receptor 2 (HER2) positive patients were most commonly ER-. The most common primary tumor site was the upper lateral quadrant. Left breast was more commonly involved. Radical surgery was the most common type of operation. Conclusion: In view of the unfavorable age of patients at the time of diagnosis and clinical and biological tumor characteristics, the results confirmed that it is of vital importance to provide breast cancer prevention, screening, and to organize breast cancer units according EUSOMA guidelines. © 2010 Zerbinis Medical Publications.


Tasic-Otasevic S.A.,University of Niš | Tasic-Otasevic S.A.,Institute of Public health Nis | Gabrielli S.V.,University of Rome La Sapienza | Tasic A.V.,Institute of Public health Nis | And 8 more authors.
BMC Infectious Diseases | Year: 2014

Background: The Northern part of Serbia is hyperendemic-endemic for canine dirofilarioses. Considering this fact, many human dirofilarial infections could be expected, however only about 30 cases in Serbia have been described until today. Aims of this survey were to assess the people reactivity to the antigens of D. repens and D. immitis and to identify risk factors for the contact exposure.Methods: Investigation included sera taken from 297 people (179 women and 118 men) living in different areas of Serbia (Pančevo, Novi Sad, Zaječar, Leskovac, Vranje, Niš, Pirot). Sera were analysed by means of two indirect enzyme-linked immunosorbent (ELISA) home-designed that use as antigens adult somatic/metabolic polyproteins of D. repens (DR) and D. immitis (DI), respectively. The results were elaborated using the statistical method of descriptive and quantitative analysis.Results: Significant differences by area in the reactivity of human sera to dirofilarial antigens were not observed (p = 0.056). A high seroreactivity was demonstrated in people from the towns of northern Serbia (Pančevo = 27,1%; Novi Sad = 16,3%), as well as in people from Zaječar (eastern Serbia = 15,8%) and Vranje (southern Serbia = 15,1%). No differences were evidenced between people reactivity to polyproteins of the two dirofilarial species, nor differences related to the gender of examinees. Factor risks evidenced were: i) place of residence; ii) spending work time outdoors during the mosquito season; iii) spending time outdoors and nearby rivers, lakes, swamps or canals; unespectedly, iv) cat owning.Conclusion: The findings emerging from this investigation indicate that clinicians and public health authorities should pay greater attention to this zoonosis. Continuing education and training of physicians will greatly contribute to the knowledge of the actual impact of filarial worms on animal and public health, and allow for the planning of suitable measures to prevent the infections. © 2014 Tasić-Otašević et al.; licensee BioMed Central Ltd.


Marjanovic G.,University of Niš | Marjanovic G.,Clinical Center Nis | Tasic N.M.,University of Niš | Tasic N.M.,Institute of Public Health Nis | And 10 more authors.
Archives of Biological Sciences | Year: 2012

Visceral leishmaniosis (VL) has emerged as an important opportunistic parasitosis associated with human immunodeficiency virus (HIV) infection. The aim of this paper is to report the first case of Leishmania/HIV coinfection in a patient from Niš (Southeastern Serbia). Microscopical examination of Giemsa-stained bone marrow (BM) smears show the presence of Leishmania spp. amastigotes based on their morphological characteristics. In spite of the parasitological finding, the serological test applied gave negative results. Molecular analyses confirmed the infection and allowed us to identify the leishmania species as Leishmania infantum (100% identity). VL/HIV coinfection has important clinical, diagnostic and epidemiological implications. In fact, the failure of serological tests is expected in this condition, and the application of molecular diagnostics to the blood may offer, apart from an easy and non-invasive diagnostic opportunity, the possibility of warning about the risk of possible nosocomial infections.


Randelovic G.,University of Niš | Mladenovic V.,Institute of Public Health Nis | Ristic L.,Institute of Public Health Nis | Otasevic S.,University of Niš | And 4 more authors.
European Journal of Pediatrics | Year: 2012

This study aimed to establish the vaginal introitus microbial flora in girls with and without symptoms of vulvovaginitis, and to present the distribution of isolated microorganisms by age groups in girls with vulvovaginitis. We enrolled 500 girls with vulvovaginitis symptoms, aged 2-12 years, referred by their pediatricians for microbiological examination of the vaginal introitus swabs, and 30 agematched asymptomatic girls. Similar microbial flora was isolated in both groups, but the symptomatic girls had significantly more common positive microbiological findings compared to controls (p<0.001). In symptomatic girls, the following pathogenic bacteria were isolated: Streptococcus pyogenes (4.2%), Haemophilus influenzae (0.4%), and Staphylococcus aureus (5.8%). Bacteria of fecal origin were found in vaginal introitus swabs in 33.8% of cases, most commonly Proteus mirabilis (14.4%), Enterococcus faecalis (12.2%), and Escherichia coli (7.0%). The finding of fecal flora wasmore common compared to controls, reaching a statistical significance (p<0.05), as well as in girls aged up to 6 years (p<0.001). Candida species were found in 2.4% of girls with vulvovaginitis symptoms. Conclusion: The microbial ecosystem in girls with clinical signs of vulvovaginitis is complex and variable, and the presence of a microorganism does not necessarily imply that it is the cause of infection. The diagnosis of vulvovaginitis in prepubertal girls requires a complex and comprehensive approach, and microbiological findings should be interpreted in the context of clinical findings. © Springer-Verlag 2012.


Vrbic S.,University of Niš | Vrbic S.,Clinical Center Nis | Pejcic I.,University of Niš | Pejcic I.,Clinical Center Nis | And 6 more authors.
Journal of B.U.ON. | Year: 2013

The therapeutic strategy for breast cancer with the use of targeted drugs is, at present, mainly focused on coping with HER2. Currently, lapatinib and trastuzumab are in widespread use. Virtually all completed and in progress clinical trials have demonstrated a significant enhancement in the rate of pathologic complete response (pCR), the primary endpoint in these studies, in cases of patients with HER2-positive breast cancer that received trastuzumab in the neoadjuvant setting. Use of lapatinib in the neoadjuvant setting should be considered experimental. When a 12-month course of trastuzumab was added to adjuvant chemotherapy, the disease-free survival (DFS) was greater and the overall survival (OS) was also greater. Although trastuzumab is approved as single-agent therapy, most patients are treated with trastuzumab plus cytotoxic agents. Trastuzumab, administered as single agent, produces durable objective responses and is well tolerated by women with HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. Dual targeting approach with a combination of trastuzumab and lapatinib improved progression-free survival (PFS) as compared with lapatinib alone in patients with metastatic breast cancer who have not had a response to trastuzumab. The combination of pertuzumab plus trastuzumab plus docetaxel, as compared with placebo plus trastuzumab plus docetaxel, when used as first-line treatment for HER2-positive metastatic breast cancer, significantly prolonged PFS. Novel anti-HER2 targeted therapies are needed to utilise novel approaches to combat trastuzumab resistance.


Tasic S.,University of Niš | Tasic S.,Institute of Public Health Nis | Miladinovic-Tasic N.,University of Niš | Miladinovic-Tasic N.,Institute of Public Health Nis | And 4 more authors.
Central European Journal of Medicine | Year: 2010

Fungal peritonitis is a rare but serious complication in patients with chronic renal failure on continuous ambulatory peritoneal dialysis (CAPD). The purpose of this study was to report the prevalence of fungal peritonitis in patients on CAPD in the Clinical Center-Nis (South Serbia) in the period from 1997 until the end of 2007. Fungal species were isolated in 66 cases (4.5%) of 1471 peritoneal fluid (PF) samples that we examined. During the study period, 22 (1.5%) cases of fungal peritonitis were registered. In 19 cases, Candida isolates were identified, Candida albicans (C. albicans) being the most common species (n=15). Two cases of fungal peritonitis caused by Aspergillus fumigatus and 1 possible case caused by Cladosporium cladosporioides (Cl. cladosporioides) were also detected. © Versita Warsaw and Springer-Verlag Berlin Heidelberg.


Kocic B.,University of Niš | Kocic B.,Institute of Public Health Nis | Filipovic S.,University of Niš | Vrbic V.,University of Niš | Pejcic I.,University of Niš
Journal of B.U.ON. | Year: 2011

Purpose: It is widely believed that breast cancer in young women is characterized by a relatively unfavorable prognosis and unusual pathological features. The aim of this study was to investigate clinicopathological and biological characteristics in young patients with breast cancer. Methods: The study enrolled 1029 consecutive female breast cancer patients who were admitted to the Clinical Centre Nis between July 2002 and December 2008. Results: 91 (8.8%)patients were under and 938 (91.2%) were over 40 years. The mean age was 35.9 years for those under 40 years and 58.3 for those older than 40 years. In both patient groups, left breast was most commonly involved; the most common primary tumor site was the upper lateral quadrant; the most common histological type was ductal carcinoma; histological and nuclear grade 2 was most common. In the younger group of patients, the proportion of patients with T3 and T4 disease was higher (13.0 vs. 9.3% and 16.5 vs. 12.0%), the number of patients with histological and nuclear grade 3 disease was higher (27.5 vs. 24.7% and 37.4 vs. 33.2%), the proportion of patients with 4-9 and >10 positive lymph nodes was higher (22.6 vs. 18.3% and 7.1 vs. 4.0%), and the percentage of family history of breast cancer was higher (5.5 vs. 3.1%), without statistically significant differences between the two age groups. Patients in the younger age group exhibited higher estrogen (ER)/progesterone (PR) receptor negativity (32.6 vs. 24.4%) (p<0.05). Conclusion: Although uncommon, breast cancer in young women is worth special attention. The underlying causes of the disease must be investigated in large population-based studies in the future. © 2011 Zerbinis Medical Publications.

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