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Maheswari K.U.,Karpaga Vinayaga Institute of Medical science | Sathyanarayanan G.,Institute of Physiology and Experimental Medicine | Sheeladevi R.,Dr Alm Postgraduate Institute Of Basic Medical Science
Biomedicine (India) | Year: 2014

Materials and Method: Aqueous extracts of Triphala and its individual fruits were prepared and its antioxidant activity was studied by scavenging assays using DPPH, superoxide anion and nitric oxide by checking for the absorbance in spectrophotometer. Lower absorbance of the reaction mixture indicates higher free radical scavenging activity. The data were compared using SPSS server version 10 and the values are expressed as Mean ±SD.Result: Triphala and its individual components showed effective antioxidant activity from 20ng/ml concentration onwards for DPPH assay and no significant statistical changes seen for superoxide assay. Only 25μg/ml of T. chebula was effective for nitric oxide assay.Conclusion: From these reports it can be concluded that all the components in Triphala is having the ability to quench free radicals.Introduction: Antioxidants become companions to the unpaired electrons of free radicals, thus minimizing the threat of molecular, cellular and tissue damage caused by free radicals. Inspite of various reports about Triphala's antioxidant capability, a drug of equal parts of three medicinal plants namely Terminalia chebula, Terminalia bellerica and Emblica officinalis, no clear in-vitro study for understanding the antioxidant role of its individual components is available. This lacuna forms the basis for this study.Aim: The aim is to find out the anti oxidant potential of Tripala

Muralikrishnan K.,Stanley Medical College | Balasubramanian K.,Stanley Medical College | Rao B.V.,Institute of Physiology and Experimental Medicine
Indian Journal of Physiology and Pharmacology | Year: 2011

Hypertension (HT) is a major silent disease affecting young people because of their hereditary and modern lifestyles. Target organ damages occur before overt hypertension is diagnosed. Many offspring of HT parents show early changes in their cardiovascular autonomic functions. Heart rate variability (HRV) provides a window to understand the cardiac autonomic balance. This study was designed to quantify and to compare the HRV among the normotensive young male offspring without history of parenteral hypertension & diabetic (control group, n=25, age 20.8±2.4, BMI 24.4±3.1) with parenteral history of hypertension & non diabetic (study group n=25, age 19.7±1.9, 24.05±3.5). Blood pressure, heart rate (HR), indices of short term HRV during supine rest and quiet standing, HR variation during timed controlled deep breathing was compared between the two groups. There were significant difference in low frequency (LF) power, HF power, total power. LF and HF expressed also in normalized units at rest and standing. In time domain standard deviation of normal to normal RR interval (SDNN) at supine rest and standing were significant. Respiratory sinus arrthymia (RSA), HF in normalized units, deep breathing difference (BDD) and the ratio of maximum RR to minimum RR were also significant in the control group than study group. In the present study there was an increased sympathetic and decreased parasympathetic activity in the study group. These findings are an early marker of cardiovascular autonomic impairment in subjects with parenteral history of hypertension.

Karthikkeyan K.,Institute of Physiology and Experimental Medicine | Padma K.,Institute of Physiology and Experimental Medicine | Vishwanatha Rao B.,Institute of Physiology and Experimental Medicine
Indian Journal of Physiology and Pharmacology | Year: 2015

Chronic Obstructive Pulmonary Disease (COPD), a progressive and partially reversible disease, has drawn world-wide attention for its moderate prevalence rate and causing central and peripheral neuropathy. Considering its severity in causing visual pathway impairment, the present investigation was carried out to find out the functional integrity of the visual pathway through visual evoked potentials (VEP) and to determine the factors influencing the condition in COPD patients. A total of 30 COPD patients of both sexes, classified according to the severity of the disease based on spirometric indices, were subjected to VEP testing and series of wave forms were measured and compared with equal number of control subjects. The latency of N75 and P100 were prolonged (P<0.01) and the P100 amplitude was reduced significantly (P<0.01) in COPD patients. Thus, the influence of COPD causing the optic neuropathy is apparent from the significant VEP changes. Non-invasive procedure can possibly be utilized as a routine screening test for COPD patients for better medical care. © 2015, Association of Physiologists and Pharmacologists of India. All Rights Reserved.

Muralikrishnan K.,Stanley Medical College | Balasubramanian K.,Stanley Medical College | Jawahar Ali S.M.,Stanley Medical College | Vishwanatha Rao B.,Institute of Physiology and Experimental Medicine
Indian Journal of Physiology and Pharmacology | Year: 2013

Obesity has been shown to affect cardiovascular function. Heart rate variability (HRV) has been an accepted method of measuring cardiovascular autonomic function. The aim of the study is to evaluate the impact of obesity on HRV using Poincaré plot (POP) analysis. A finding of sympathovagal imbalance in pre-obese adults in respiratory sinus arrhythmia (RSA) could provide important diagnostic information about early subclinical autonomic dysfunction in obesity. Thirty one obese (BMI 26.84±2.47) adult males (25.42±7.86 years) were compared with 31 normal subjects (25.38±4.61 years). In all participants, anthropometric and blood pressure (BP) measurements were performed. After rest at supine position for 5 minutes, they were asked to do control deep breathing for 1 minute. HRV was measured in terms of POP analysis. Differences in Resting heart rate (RHR) (P≤0.025), Pulse pressure (PP) (P≤0.048), SD1 (P≤0.042) and SD2 (P≤0.039) of the POP between the two groups were significant. Correlation between Body mass index (BMI) and (PP) (p=0.19); SD1 (p=0.47) and SD2 (p=0.39) of the POP were significant in obese groups. Obesity is related to sympathovagal imbalance characterized by depressed parasympathetic tone and increased sympathetic activity. Nonlinear methods like POP permit simple assessment of autonomic function, despite measuring different aspects of HRV.

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