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Das C.,The Pharmaceutical College | Dash S.,Institute of Pharmacy and Technology
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Tecoma stans Linn. (Leguminosae) is an useful traditional plant used in the treatment of diabetes, yeast infection, syphilis. Leaves and flower have medicinal value for the treatment of various cancer. The plant is considered as an effective remedy for snake and rats bites and for scorpion sting, diuretic, vermifuge and tonic. Only a very limited research has been carried out on the plant, under the present study assumes singular significance and it is supposed to contribute a great deal to the existing literature. The present paper highlights the macroscopic and microscopic characters of leaf and petiole studies of the plant (leaves). These observations would be of immense value in the botanical identification and standardization of the drug in crude form. This study would help distinguish the drug from its other species. Source

Parhi R.,Gandhi Institute of Technology and Management | Suresh P.,Institute of Pharmacy and Technology
Materials Science and Engineering C | Year: 2016

Matrix type of simvastatin transdermal film (SSTF) was developed with poly(vinyl alcohol) (PVA) and eudragit RL100 (EG) using response surface methodology (RSM) to investigate combined effect of the selected process variables like SS concentration, PVA:EG ratio and the dibutyl phthalate (DBT) concentration at different levels on dependent variables such as tensile strength and flux, with an aim to optimize a suitable combination of drug, polymer and plasticizer ratio. The study reveals that the effect of DBT concentration was highest on tensile strength, while SS concentration exhibited pronounced effect on SS flux through the abdominal skin of rat. According to Derringer's desirability prediction tool, the composition of optimized film was found to be 2% of SS, 2:1 ratio of PVA:EG and 40% of DBT. Under these conditions, the SSTF exhibited a predicted value of tensile strength and flux of 11.871 MPS and 43.569 μg/cm2/h, respectively. The in vivo hypolipidemic study conducted for 14 days in hyperlipidemia induced Sprague-Dawley rats reveals that the optimized SSTF exhibited significant lowering of blood lipid level. The absence of skin irritation indicates that the prepared film was safe and well tolerated as transdermal formulation. Thus, the film may serve as an alternative therapy to oral dosage form of SS. © 2015 Elsevier B.V. All rights reserved. Source

Sahoo M.,Institute of Pharmacy and Technology
Oriental Pharmacy and Experimental Medicine | Year: 2013

Ethanol extract of the of rhizome of Nymphaea alba, at graded doses was investigated for the central depressant activity of the ethanol extract of rhizome. The behavioral effect of the extract (75, 150 and 300 mg/kg) was evaluated using diazepam induced sleep test, hole-board test, beam walking assay, staircase test, open field test and elevated plus maze assay, all in mice. The findings of this study suggest that the extract of N. alba rhizome contains some bioactive principles that are sedative in nature. © 2013 Institute of Oriental Medicine, Kyung Hee University. Source

Senapati A.K.,Institute of Pharmacy and Technology | Swain S.R.,MET Group of Institutions | Satyanarayana S.,Andhra University
Pharmacologyonline | Year: 2011

The objective of the present study was to evaluate acute and subchronic toxicity studies of Pterospermum acerifolium (P. acerifolium) flowers in albino mice and rats. Phytochemical investigation was also carried out to know type of phytoconstituents present in the flowers of P. acerifolium. Hydroalcoholic flower extracts at a dose of 1000, 2000 and 4000 mg/kg was administered orally to the test groups while distilled water was given to the control. The parameters measured include food and fluid intake, body weight, absolute and relative weight of various organs [Lung, Liver, Pancreas, Kidney, Heart and Spleen], haematological parameters [total white blood cell (WBC) and packed cell volume (PCV)], and tests for liver function: Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase and total bilirubin. The lethal dose (LD50) was found to be greater than 4000 mg/kg (p.o.) in both mice and rats. Rats treated with the extract had no progressive increase in body weight. No significant increase in fluid and food intake was observed in rats treated with hydroalcoholic extract of P. acerifolium flowers. There were no significant changes in both the absolute and relative organ weights between the control and the test groups. The liver enzymes and haematological parameters were statistically equal in all the groups. P. acerifolium hydroalcoholic flower extract is found to be non-toxic in albino rats. Source

Dash G.K.,Institute of Pharmacy and Technology
International Journal of Pharma and Bio Sciences | Year: 2011

The petroleum ether, chloroform, methanol and aqueous extracts of the leaves of Ageratum conyzoides Linn. (Asteraceae) were evaluated for their wound healing activity in rats using excision (normal and infected), incision and dead space wound models respectively. The effects of test samples on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation, wound breaking strength, weights of the granulation tissue, determination of hydroxyproline, super oxide dismutase (SOD), catalase and histopathology of the granulation tissues. Nitrofurazone (0.2% w/w) in Simple ointment I. P. was used as reference standard for the activity comparison. The results of the study revealed that the animals treated with methanol and aqueous extracts of A. conyzoides showed faster rate of wound healing compared to other extracts under study. The chloroform extract of the selected plants also produced promising results but the effects are seen to be of lesser extent than the corresponding methanol and aqueous extracts. The petroleum ether extract did not produce significant results. The present work justifies the use of the leaves of A. conyzoides for wound healing activity as claimed in the folklore literature. Source

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