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Bose A.,Institute of Pharmacy and Technology | Sahoo M.,Institute of Pharmacy and Technology
Oriental Pharmacy and Experimental Medicine | Year: 2012

Ethanol extract of the of rhizome of Nymphaea alba, at graded doses was investigated for anti-diarrhoeal activity in term of reduction in the rate of defecation in castor oil induced diarrhoea and anti-inflammatory activity in term of reduction in inflammation of rat paw. To understand the mechanism of its anti-diarrhoeal activity, its effect was further evaluated on intestinal transit and castor oil induced intestinal fluid accumulation (enteropooling). At various doses (100 & 200 mg/kg body weight) the extract showed a remarkable anti-diarrhoeal activity evidenced by the reduction in the rate of defecation. Results are comparable to that of standard drug diphenoxylate (5 mg/kg body weight). A single oral dose of N. alba extract of 100 mg/kg body weight produced a significant decrease in the severity of diarrhoea. Extract produced profound decrease in intestinal transit (25. 73 and 37. 29%) also significantly inhibited castor oil induced enteropooling comparable to that of intraperitoneal injection of standard drug atropine sulphate at doses of 0. 1 mg/kg body weight and loperamide at 5 mg/kg body weight respectively. Results indicate N. alba possess significant anti-diarrhoeal activity and may be a potent source of anti-diarrhoeal drug in future. But the extract did not show anti-inflammatory activity. © 2012 Institute of Oriental Medicine, Kyung Hee University.


Sahoo M.,Institute of Pharmacy and Technology
Oriental Pharmacy and Experimental Medicine | Year: 2013

Ethanol extract of the of rhizome of Nymphaea alba, at graded doses was investigated for the central depressant activity of the ethanol extract of rhizome. The behavioral effect of the extract (75, 150 and 300 mg/kg) was evaluated using diazepam induced sleep test, hole-board test, beam walking assay, staircase test, open field test and elevated plus maze assay, all in mice. The findings of this study suggest that the extract of N. alba rhizome contains some bioactive principles that are sedative in nature. © 2013 Institute of Oriental Medicine, Kyung Hee University.


Patro S.K.,Institute of Pharmacy and Technology | Kanungo S.K.,Institute of Pharmacy and Technology | Choudhury N.S.K.,S Cb Medical College
E-Journal of Chemistry | Year: 2010

A simple, rapid and accurate and stability indicating RP-HPLC method was developed for the determination of valsartan in pure and tablet forms. The method showed a linear response for concentrations in the range of 50-175 μg/mL using 0.01 M NH4H2PO4 (pH 3.5) buffer: methanol [50:50] as the mobile phase with detection at 210 nm and a flow rate of 1 mL/min and retention time 11.041 min. The method was statistically validated for accuracy, precision, linearity, ruggedness, robustness, forced degradation, solution stability and selectivity. Quantitative and recovery studies of the dosage form were also carried out and analyzed; the % RSD from recovery studies was found to be less than 1. Due to simplicity, rapidity and accuracy of the method, we believe that the method will be useful for routine quality control analysis.


Patro S.K.,Institute of Pharmacy and Technology | Swain S.R.,Institute of Pharmacy and Technology | Choudhury N.S.K.,Scb Medical College
E-Journal of Chemistry | Year: 2010

A new, simple, specific, accurate and precise RP-HPLC method was developed for determination of lamivudine in pure and tablet formulations. A Thermo BDS C18 column in isocratic mode, with a mobile phase consisting of 0.01 M ammonium dihydrogen orthophosphate buffer adjusted to pH 2.48 by using formic acid and methanol in the ratio of 50:50 was used. The flow rate was set at 0.6 mL/min and UV detection was carried out at 264 nm. The retention time of lamivudine and nevirapine were 2.825 min and 4.958 min respectively. The method was validated for linearity, precision, robustness and recovery. Linearity for lamivudine was found in the range of 50-175 μg/mL. Hence, it can be applied for routine quality control of lamivudine in bulk and pharmaceutical formulations.


Das C.,The Pharmaceutical College | Dash S.,Institute of Pharmacy and Technology
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Tecoma stans Linn. (Leguminosae) is an useful traditional plant used in the treatment of diabetes, yeast infection, syphilis. Leaves and flower have medicinal value for the treatment of various cancer. The plant is considered as an effective remedy for snake and rats bites and for scorpion sting, diuretic, vermifuge and tonic. Only a very limited research has been carried out on the plant, under the present study assumes singular significance and it is supposed to contribute a great deal to the existing literature. The present paper highlights the macroscopic and microscopic characters of leaf and petiole studies of the plant (leaves). These observations would be of immense value in the botanical identification and standardization of the drug in crude form. This study would help distinguish the drug from its other species.


Dash G.K.,Institute of Pharmacy and Technology
International Journal of Pharma and Bio Sciences | Year: 2011

The petroleum ether, chloroform, methanol and aqueous extracts of the leaves of Ageratum conyzoides Linn. (Asteraceae) were evaluated for their wound healing activity in rats using excision (normal and infected), incision and dead space wound models respectively. The effects of test samples on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation, wound breaking strength, weights of the granulation tissue, determination of hydroxyproline, super oxide dismutase (SOD), catalase and histopathology of the granulation tissues. Nitrofurazone (0.2% w/w) in Simple ointment I. P. was used as reference standard for the activity comparison. The results of the study revealed that the animals treated with methanol and aqueous extracts of A. conyzoides showed faster rate of wound healing compared to other extracts under study. The chloroform extract of the selected plants also produced promising results but the effects are seen to be of lesser extent than the corresponding methanol and aqueous extracts. The petroleum ether extract did not produce significant results. The present work justifies the use of the leaves of A. conyzoides for wound healing activity as claimed in the folklore literature.


Parhi R.,Gandhi Institute of Technology and Management | Suresh P.,Institute of Pharmacy and Technology
Materials Science and Engineering C | Year: 2016

Matrix type of simvastatin transdermal film (SSTF) was developed with poly(vinyl alcohol) (PVA) and eudragit RL100 (EG) using response surface methodology (RSM) to investigate combined effect of the selected process variables like SS concentration, PVA:EG ratio and the dibutyl phthalate (DBT) concentration at different levels on dependent variables such as tensile strength and flux, with an aim to optimize a suitable combination of drug, polymer and plasticizer ratio. The study reveals that the effect of DBT concentration was highest on tensile strength, while SS concentration exhibited pronounced effect on SS flux through the abdominal skin of rat. According to Derringer's desirability prediction tool, the composition of optimized film was found to be 2% of SS, 2:1 ratio of PVA:EG and 40% of DBT. Under these conditions, the SSTF exhibited a predicted value of tensile strength and flux of 11.871 MPS and 43.569 μg/cm2/h, respectively. The in vivo hypolipidemic study conducted for 14 days in hyperlipidemia induced Sprague-Dawley rats reveals that the optimized SSTF exhibited significant lowering of blood lipid level. The absence of skin irritation indicates that the prepared film was safe and well tolerated as transdermal formulation. Thus, the film may serve as an alternative therapy to oral dosage form of SS. © 2015 Elsevier B.V. All rights reserved.


PubMed | Institute of Pharmacy and Technology and Gandhi Institute of Technology and Management
Type: | Journal: Materials science & engineering. C, Materials for biological applications | Year: 2015

Matrix type of simvastatin transdermal film (SSTF) was developed with poly(vinyl alcohol) (PVA) and eudragit RL100 (EG) using response surface methodology (RSM) to investigate combined effect of the selected process variables like SS concentration, PVA:EG ratio and the dibutyl phthalate (DBT) concentration at different levels on dependent variables such as tensile strength and flux, with an aim to optimize a suitable combination of drug, polymer and plasticizer ratio. The study reveals that the effect of DBT concentration was highest on tensile strength, while SS concentration exhibited pronounced effect on SS flux through the abdominal skin of rat. According to Derringers desirability prediction tool, the composition of optimized film was found to be 2% of SS, 2:1 ratio of PVA:EG and 40% of DBT. Under these conditions, the SSTF exhibited a predicted value of tensile strength and flux of 11.871 MPa and 43.569 g/cm(2)/h, respectively. The in vivo hypolipidemic study conducted for 14 days in hyperlipidemia induced Sprague-Dawley rats reveals that the optimized SSTF exhibited significant lowering of blood lipid level. The absence of skin irritation indicates that the prepared film was safe and well tolerated as transdermal formulation. Thus, the film may serve as an alternative therapy to oral dosage form of SS.


Das S.K.,Institute of Pharmacy and Technology | Grewal A.S.,Institute of Pharmacy and Technology | Banerjee M.,Institute of Pharmacy and Technology
International Journal of Pharmaceutical Sciences Review and Research | Year: 2011

The research development of heavy metal is not a new area of science, having existed for around more than a century. The study of heavy metal is called heavy metal science. It is a provocative field of science, having experienced steady and strong growth over its history, with many companies investing large amounts of money into the development of new method to estimating and eliminating heavy metal from the different house hold thing, cosmetics, food and drug formulation. This review was focused on the heavy metal toxicity and its estimating different analytical technique that are now in development.


Biswal S.,Institute of Pharmacy and Technology | Sahoo U.,Institute of Pharmacy and Technology | Sethy S.,Institute of Pharmacy and Technology | Kumar H.K.S.,Institute of Pharmacy and Technology | Banerjee M.,Institute of Pharmacy and Technology
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

A large number of efforts were made to synthesize different heterocyclic compounds and their derivatives in the past decade and were found to posses promising antitumor, anticonvulsant, antimicrobial, anti-tubercular and anti diabetic activities. Although indole moiety is very small but is fascinated by scientists because of the diverse biological activities by not only indole but its various substituted derivatives as well. This review was focused on the indole and its derivatives that are now in development. Due to its wider applications in pharmaceutical industries, they will replace many existing heterocyclic based pharmaceuticals. Now days, many drugs are in the world market, while several hundred are in clinical trials.

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