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Ilin A.,Scientific Center for Anti Infectious Drugs | Kulmanov M.,Scientific Center for Anti Infectious Drugs | Nersesyan A.,Medical University of Vienna | Stopper H.,Institute of Toxicology and Pharmacology
Journal of B.U.ON. | Year: 2015

Purpose: The purpose of this study was to determine possible genotoxic effects of a new very promising antibacterial/antiviral drug FS-1. Methods: The drug was tested in TA98, TA100, TA102, TA1535 and TA1537 strains of Salmonella (Ames test) with and without metabolic activation, and also in mouse lymphoma L5178Y cells by means of micronucleus and comet assays. In microbes the drug was tested at concentrations up to 500 ug/plate and in mouse lymphoma cells up to 2, 000 ug/ml. Results: In both test-systems in all experiments completely negative results were obtained although FS-1 was tested at maximum tolerated doses. Conclusions: The drug is not genotoxic. This is advantageous because many antibacterial/antiviral drugs possess such activity. Source

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