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Appa Rao A.V.N.,Kakatiya University | Rajitha G.,Institute of Pharmaceutical Technology
Indian Journal of Natural Products and Resources | Year: 2014

Tarenna asiatica (L.) Kuntze ex K. Schum. (Magnoliophyta: Rubiaceae) is traditionally used as anthelmintic, antiseptic, antiulcer and to promote suppuration. The leaf-bud exudates collected from the local forests was extracted with benzene by maceration. Preliminary chemical tests were conducted for select secondary metabolites aside isolating the known flavone, corymbosin. Employing the cup-plate method, different concentrations of benzene extract and corymbosin were screened against Bacillus sphaericus, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus, using streptomycin as the standard drug. The extract evinced a weak to moderate activity against all the strains tested while corymbosin was inactive. The antioxidant activity of the benzene extract was studied by nitric oxide scavenging activity, reduction of DPPH free radical, iron-induced lipid peroxidation and superoxide scavenging activity, with ascorbic acid as the standard drug. The extract was found to be IC50 in the range of 20-60 g/mL in the assays performed.

Thaakur S.,Institute of Pharmaceutical Technology
Journal of neural transmission (Vienna, Austria : 1996) | Year: 2010

Epidemiological studies indicate that the intake of Mediterranean-style diet is inversely associated with risk of stroke, cardiovascular diseases, and cancer. Spirulina is widely used nutritional supplement rich in proteins and antioxidants. Evidence demonstrates that the impaired energy metabolism and the excessive generation of reactive oxygen radicals contribute to the brain injury associated with cerebral ischemia. In the present study, the protective effect of Spirulina was investigated in transient middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia-reperfusion injury in rats. Male albino rats were divided into six groups: control, sham-operated group, ischemic control group, and Spirulina-pretreated groups (45, 90 and 180 mg/kg/p.o.). Spirulina was administered once a day, for 7 days. The rats were subjected to a 2-h right MCAO via the intraluminal filament technique and 22 h of reperfusion. Pretreatment with Spirulina significantly reduced the histological changes and neurological deficits. Spirulina at a dose of 180 mg/kg significantly reversed the elevated brain malondialdehyde (MDA) content and restored the decreased activities of brain superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) indicating that Spirulina has the protective potential against cerebral ischemia injury and its protective effects may be due to its antioxidant property.

Swathi D.,Scient Institute of Pharmacy | Prasad K.V.S.R.G.,Institute of Pharmaceutical Technology | Sree P.R.,Scient Institute of Pharmacy | Jalaiah M.,Scient Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2013

The ethanolic extract of roots of Cocculus hirsutus has been useful of various ailments (Tuberculosis, leprosy, skin diseases, dyspepsia, pruritis etc.). To determine the gastroprotective effect of Cocculus hirsutus in model of ethanol induced ulcer rat, the ethanolic extract is given by oral gauges (100mg/kg) and (200mg/kg) half an hour prior to the administration of ethanol (1 ml of 96%).The antioxidant parameters were also determined in this model. C.hirsutus treatment significantly reduced the ulcer index, lipid peroxidation (LPO) and significant increase in catalase, nitrite, thereby justifying it's use as an anti ulcerogenic agent.

Gurrapu A.,Institute of Pharmaceutical Technology | Jukanti R.,St Peters Institute Of Pharmaceutical Science | Bobbala S.R.,St Peters Institute Of Pharmaceutical Science | Kanuganti S.,St Peters Institute Of Pharmaceutical Science | Jeevana J.B.,Institute of Pharmaceutical Technology
Advanced Powder Technology | Year: 2012

Proniosome powders proved to be the potential carriers for efficient oral delivery of lipophilic or amphiphilic drugs. Henceforth, an attempt was made to improve the oral delivery of valsartan by loading into maltodextrin based proniosome powders. The proniosome powders were prepared by varying the ratio of span 60 and cholesterol and evaluated for micromeritic properties and the results indicate acceptable flow properties. The formulation containing equimolar ratio of span 60 and cholesterol showed smaller vesicle size, high surface charge and entrapment efficiency. The formation of niosomes and surface morphology of optimized proniosome formulation was studied by optical and scanning electron microscopy, respectively. FT-IR, differential scanning calorimetry, and powder X-ray diffraction studies performed to understand the solid state properties of the drug reveal the absence of chemical interaction, drug transformation from crystalline to amorphous and molecular state. The in vitro dissolution study carried out in both simulated gastric and intestinal fluid demonstrate improved dissolution characteristics compared to pure drug. The augment in permeation enhancement from proniosome formulation across rat intestine suggest the potential of proniosome carriers for improved oral delivery of valsartan. © 2011 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder.

Thaakur S.R.,Institute of Pharmaceutical Technology | Pokkula S.,Institute of Pharmaceutical Technology
International Journal of Pharma and Bio Sciences | Year: 2013

The present study was aimed at investigating the ameliorative effects of Vanda testacea (VT) in sciatic nerve transection (axotomy)-induced peripheral neuropathy in rats. Adult male albino rats weighing 130-150gm were used for the study, and were divided into five groups and axotomy was performed on left sciatic nerve in group II to group V. Tail cold-hyperalgesia, motor co-ordination, foot deformation tests, and total calcium levels were estimated to assess the extent of neuropathy. Superoxide dismutase (SOD), catalase (CAT), lipid peroxides (LPO), calcium, prostaglandin E2 levels were estimated. Hydro-alcoholic extract of VT was administered at a dose of 175 and 350 mg/kg/p.o for 15 days. VT attenuated sciatic nerve transection-induced motor in-coordination, reversed axotomy-induced alterations in lipid peroxides, total calcium, superoxide dismutase, catalase levels in a dose-dependent manner. Ameliorative effects of VT in axotomy-induced neuropathy may be due to its antioxidant, calcium and prostaglandin attenuating actions.

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