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Baviskar D.,Institute of Pharmaceutical Education | Jain D.,P.A. College
Tropical Journal of Pharmaceutical Research | Year: 2013

Purpose: To develop and optimise sustained release (SR) matrix tablets of diltiazem hydrochloride (DHL). Methods: DHL tablets were prepared by direct compression and consisted of hydroxyprpoylmethyl cellulose, Kollidon SR and Eudragit RSPO. A 32 full factorial design was applied to study the effect of polymers used on drug release from the DHL. The tablets were also evaluated for physicochemical characteristics and release kinetics. In vivo human volunteer studies were carried out on the optimised formulation with a commercial sustained release product serving as reference. Results: The physicochemical characteristics of all prepared tablets were satisfactory. The developed drug delivery system provided prolonged drug release rates over a period of 24 hours. The release profile of the developed formulation was described by the Higuchi model. Mean time of occurrence for maximum (peak) drug concentration (Tmax) was 2.05 ± 0.52 and 2.30 ± 0.57 h for the optimized and commercial formulations, respectively, while mean maximum concentration of drug (Cmax) was 501.74 ± 0.05 and 509.65 ± 0.06, ng/ml respectively. Good correlation between the dissolution profiles and bioavailability was observed using the method of linear regression analysis and correlation coefficient. Conclusion: A fair correlation between in vitro dissolution and in vivo data was found. The results obtained indicate successful development of a sustained release formulation of diltiazem. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved. Source


Baviskar D.T.,Institute of Pharmaceutical Education | Biranwar Y.A.,Institute of Pharmaceutical Education | Bare K.R.,Institute of Pharmaceutical Education | Parik V.B.,Institute of Pharmaceutical Education | And 2 more authors.
Tropical Journal of Pharmaceutical Research | Year: 2013

Purpose: To develop diclofenac sodium gel using high molecular weight hydroxypropyl methylcellulose (HPMC) and Carbopol 934P for topical and systemic delivery. Methods: Diclofenac sodium gel was prepared with HPMC K100M and Carbopol 934P as gelling agents. The formulations were examined for pH, spreadability, consistency, viscosity, homogeneity, drug content and stability. In vitro drug release was evaluated using Franz diffusion cell. Carrageenaninduced rat paw oedema model was used for the evaluation of the anti-inflammatory activity of the gels. A commercial diclofenac sodium gel product was used as the reference drug. Results: Formulations containing glycerin as permeation enhancer gave drug release patterns comparable to that of the reference product. The drug content of F2, F5 and F9 was 99.81, 99.75 and 99.96 %, respectively. Accelerated stability results showed no significant variation in the appearance and drug release after storage for 3 months. Conclusion: Diclofenac sodium gel containing HPMC K100M and Carbopol 934P exhibited pronounced anti-inflammatory activity and could be further developed for topical and systemic delivery. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved. Source


Sonawane Kalyani V.,Institute of Pharmaceutical Education | Biranwar Yogeshkumar A.,Institute of Pharmaceutical Education | Rajput Amarjit P.,Institute of Pharmaceutical Education | Baviskar Dheeraj T.,Institute of Pharmaceutical Education | Jain Dinesh K.,P.A. College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

The main object of this study was to obtain a reliable determination of symptoms prevalence in patients with cancer due to performing the systematic review of studies assessing related topic multiple biomedical imaging techniques are used in various phases of cancer management. Imaging forms an important part of cancer clinical protocols and it is probable to furnish morphological, structural, metabolic and functional information. Integration with other diagnostic tools such as in vitro tissue and fluids analysis assists in clinical decision-making. Care and treatment of advanced care are focused on the management and relief of symptoms, as well as increase the patient's satisfaction and quality of life. Information of symptom prevalence is important for clinical practice. For ensure the safety and optimize efficacy and careful patient selection for involving in the phase I trials is warranted. Therefore a validation study on existing phase I prognostic scores and subsequently aimed to make it an even more simple prognostic score. The results of this study should be used to guide doctors and nurses in symptoms management. Proper attention to symptoms burden and suffering should be the basis for individually tailored treatment aimed at improving or maintaining quality of life of patient. Source


Baviskar D.T.,Institute of Pharmaceutical Education | Pawar M.P.,Institute of Pharmaceutical Education | Kale S.S.,Institute of Pharmaceutical Education | Jain P.D.,IPS ACADEMY | Jain D.K.,IPS ACADEMY
Asian Journal of Chemistry | Year: 2011

A simple rapid, selective sensitive and novel high pressure liquid chromatographic (HPLC) method was developed and validated for the assay of propranolol. Sample preparation was performed by liquid-liquid extraction in ethyl acetate. The organic solvent was evaporated and the residue dissolved in a mobile phase. Aliquots of 60 μL were injected automatically into the chromatograph. The separation of propranolol was achieved on a reversed phase C18 column with a mobile phase consisting of 10 mM ammonium acetate, acetonitrile,: TEA (70:30:0.01 v/v/v). Quantitation of propranolol was performed by UV detection at 210 nm. The linearity range was 5 to 80 ng/mL. Interday and intra day accuracy and precision was found 91.26-109.13, 2.79-5.79 and 92.15-108.52, 1.52-5.67 respectively. Long term stability for 30 days of propranolol in human plasma was proved as per guidelines. Source

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