PubMed | National Institute of Pathology Indian Council of Medical Research and Guru Gobind Singh Indraprastha University
Type: Journal Article | Journal: Genomics | Year: 2016
TiD is a standalone application, which relies on basic assumption that a protein must be essential for pathogens survival and non-homologous with host to qualify as putative target. With an input bacterial proteome, TiD removes paralogous proteins, picks essential ones, and excludes proteins homologous with host organisms. The targets illustrate non-homology with at least 40 out of 84 gut microbes, considered safe for human. TiD classifies proposed targets as known, novel and virulent. Users can perform pathway analysis, choke point analysis, interactome analysis, subcellular localization and functional annotations through web servers cross-referenced with the application. Drug targets identified by TiD for Listeria monocytogenes, Bacillus anthracis and Pseudomonas aeruginosa have revealed significant overlaps with previous studies. TiD takes <2h to scan putative targets from a bacterial proteome with ~5000 proteins; hence, we propose it as a useful tool for rational drug design. TiD is available at http://bmicnip.in/TiD/.
Dalal V.,National Institute of Pathology Indian Council of Medical Research |
Kaur M.,National Institute of Pathology Indian Council of Medical Research |
Siraj F.,National Institute of Pathology Indian Council of Medical Research |
Singh A.,National Institute of Pathology Indian Council of Medical Research |
Bansal A.,National Institute of Pathology Indian Council of Medical Research
Journal of the Canadian Urological Association | Year: 2015
Primary testicular lymphoma (PTL) is an uncommon disease, and accounts for about 1% to 2% of non-Hodgkin’s lymphomas and less than 5% of all testicular malignancies. Of all testicular malignances, primary testicular diffuse large B-cell lymphoma is the most common type, whose incidence is estimated at 0.26/100 000 per year. At presentation or relapse, PTL tends to spread to several extranodal sites, such as the contralateral testis, the central nervous system, skin, lung, pleura, Waldeyer’s ring, and soft tissues. Orchiectomy and chemotherapy are the preferred treatment. We report a case of a 40-year-old male presenting with a nodule on the anterior abdominal wall and with right scrotal swelling on physical examination. Histopathologic examination led to the diagnosis of cutaneous metastasis of testicular lymphoma. © 2015 Canadian Urological Association.