PubMed | Babol University of Medical Sciences and Razi Institute of Pathobiology
Type: Journal Article | Journal: Epidemiology and infection | Year: 2016
To determine the time to appearance of antibody against hepatitis B surface antigen (anti-HBs) after clearance of hepatitis B surface antigen (HBsAg) in chronically infected individuals, we followed up 3963 cases with positive antibody against hepatitis B e antigen (anti-HBe) from 1991 to 2014. Of these, 101 (67 males, 34 females) lost HBsAg. These serocleared cases were checked every 6-month interval regarding HBsAg, anti-HBs, liver function tests, and liver sonography. Hepatitis B virus DNA was assessed at the time of seroclearance or the appearance of anti-HBs. The mean age of these patients at entry to this study was 344 13 years. The mean follow-up duration until seroclearance of HBsAg was 66 43 years. After the mean follow-up of 437 45 months, anti-HBs appeared in 64 (634%) cases. The cumulative probabilities of anti-HBs appearance for 2, 5 and 10 years were 243%, 58% and 782%, respectively. The appearance of anti-HBs was associated with age 35 years and seroclearance of HBsAg (hazard ratio 196, 95% confidence interval 132-338, P = 0016) but not with sex. The results show that anti-HBs may develop in 782% of cases within 10 years of HBsAg clearance. Age 35 years at HBsAg loss was associated with earlier development of anti-HBs.