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Institute Of Orthopedic Research & Education | Date: 2016-08-26

Herein disclosed is a tissue supplied in a configuration pre-shaped to the topography of the recipient surface for covering defects in the articulating surfaces of bones. Also discussed herein is a method of preparing a graft for reconstruction of a defect in an articular surface of a bone comprising determining the topography of the native articular surface and the corresponding underside of the cartilage layer; fabricating a pair of mating surfaces having the topography of the native articular surface and the underside of the cartilage layer; harvesting a cartilage graft from a cadaveric donor; and placing said graft between the mating surfaces and subjecting said graft to sufficient pressure for a sufficient duration to cause it to change shape to that of the deforming surfaces.

PubMed | Houston Methodist Hospital and Institute of Orthopedic Research & Education
Type: Journal Article | Journal: Journal of experimental orthopaedics | Year: 2016

The objective of rehabilitation following meniscal repair is to promote healing by limiting stresses on repairs, while simultaneously preserving muscle strength and joint motion. Both protective protocols limiting weight bearing and accelerated which do not, have shown clinical success. This study assesses the effects of physiologic gait loading on the kinematic behavior of a repaired medial meniscus.The medial menisci of eight fresh cadaveric knees were implanted with arrays of six 0.8-1.0mm beads. Pneumatic actuators delivered muscle loads and forces on the knee as each specimen was subjected to a simulated stance phase of gait. Meniscus motion was measured at loading response, mid stance, and toe-off positions. Measurements were performed using biplanar radiography and RSA, with each knee: (a) intact, (b) with posterior longitudinal tear, and (c) after inside-out repair.The tissue spanning the site of the longitudinal tear underwent compression rather than gapping open in all states (intact [I], torn [T] and repaired [R] states). Average compression at three sites along the posterior half of the meniscus was: posterior horn -0.200.08mm [I], -0.390.10mm [T], and -0.200.06mm [R] (p=0.15); junction of posterior horn and body -0.110.12mm [I], -0.2112mm [T], -0.170.09mm [R] (p=0.87); and adjacent to the medial collateral ligament -0.070.06mm [I], -0.290.13mm [T], -0.070.17mm [R] (p=0.35). The entire meniscus translated posteriorly from mid-stance to toe off. Displacement was greatest in the torn state compared to intact, but was not restored to normal levels after repair.The edges of a repaired longitudinal medial meniscal tear undergo compression, not gapping, during simulated gait.

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