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News Article | November 18, 2016
Site: www.prnewswire.co.uk

Laureates to be recognized by Research and Academic Leaders at Awards Ceremony on December 1st in Moscow The organizers of Prix Galien Russia have today released the nominees for the third edition of the Awards. The Prix Galien Russia Committee (or Jury) comprises 15 renowned leaders in biomedical research and academia and is responsible for evaluating nominees based on scientific files. Laureates will be honored at the Prix Galien Russia Awards Ceremony at Volkhonka Mansion, on the 1st of December 2016 The Prix Galien Russia Committee designates a laureate in 6 different categories by evaluating scientific applications files submitted by the candidates based solely on two questions: Frederic Boucheseiche, General Secretary of Prix Galien Russia, reiterated the uniqueness and importance of Prix Galien by emphasizing the fact that the Jury's decision is based only on scientific and medical criteria, that marketing and commercial considerations never enter into the Jury's decision, and by restating that pharmaceutical companies cannot sponsor the event. "Organizing an awards ceremony under such strict principles is extremely challenging, but this is the condition that guarantees the impartiality of the jury's decision. Prix Galien Russia uses the same strict criteria as in all other countries where the award is held, making its legitimacy indisputable." Frederic Boucheseiche. Nominees for the Prix Galien Russia 2016 Awards are: Development of a new generation of Antivirals of the family of azoloazines - Institute of Organic Synthesis OncoFinder platform for personalized selection of drugs in oncology - First Oncology Research and Advisory Center ImmunoQuantex  "Femoflor®"+    «ImmunoQuantex" - DNA-Technology LLC/ Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology" Ministry of Healthcare of the RF Prix Galien Russia was inaugurated in Moscow in 2013 under the auspice of an exceptional awards committee composed of eminent specialists involved in the sphere of Russian and international pharmaceutical research. A Prix Galien Award is considered the biomedical industry's highest accolade and recognizes the technical, scientific and clinical research skills necessary to develop innovative medicines. Around the world, Prix Galien rewards outstanding achievements in improving the global human condition through the development of innovative therapies. Created in France 40 years ago, Prix Galien has selection committees in 16 countries around the world.


Nurkenov O.A.,Institute of Organic Synthesis | Fazylov S.D.,Institute of Organic Synthesis | Satpaeva Z.B.,Institute of Organic Synthesis | Turdybekov K.M.,International Scientific and Industrial Holding Phytochemistry | And 4 more authors.
Russian Journal of General Chemistry | Year: 2015

Hydrolysis of thiosemicarbazides obtained by reacting p-hydroxybenzoic acid hydrazide with alkyl isocyanates occurs via intramolecular heterocyclization affording substituted 4-3-(4-hydroxyphenyl)-1H-1,2,4-triazole-5(4H)-thiones in a high yield. © 2015 Pleiades Publishing, Ltd.


Kubas H.,Merz Pharmaceuticals GmbH | Meyer U.,Merz Pharmaceuticals GmbH | Krueger B.,Merz Pharmaceuticals GmbH | Hechenberger M.,Merz Pharmaceuticals GmbH | And 7 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2013

A virtual screening approach using various in silico methodologies led to the discovery of 2-(m-tolylamino)-7,8-dihydroquinazolin-5(6H)-one (1) as a moderately active negative allosteric modulator (NAM) of the metabotropic glutamate receptor subtype 5 (mGluR5) showing high selectivity against the subtype mGluR1. Modifications of the parent compound by rational design yielded a series of highly potent derivatives which will serve as valuable starting points for further hit-to-lead optimization efforts toward a suitable drug candidate for the treatment of l-DOPA induced dyskinesia. © 2013 Elsevier Ltd. All rights reserved.


Il'in A.I.,Anti Infective Drugs Research Center | Kulakov I.V.,Institute of Organic Synthesis | Leonova N.V.,Anti Infective Drugs Research Center | Kasymbekova S.S.,Anti Infective Drugs Research Center | And 2 more authors.
Russian Journal of General Chemistry | Year: 2011

Reactions of (N-1-methylglucosaminocarbonothioyl)-4-bromobenzamide with copper(II) sulfate in the ratios 1:1 and 2:1 affords the corresponding chelate complexes of the metal. Their structure was proved by high resolution mass spectrometry. The complex of (N-1-methylglucosaminocarbonothioyl)-4- bromobenzamide with copper(II) sulfate (ratio 1:1) exhibits pronounced antibacterial activity. © Pleiades Publishing, Ltd., 2011.


Kubas H.,Merz Pharmaceuticals GmbH | Meyer U.,Merz Pharmaceuticals GmbH | Hechenberger M.,Merz Pharmaceuticals GmbH | Klein K.-U.,Merz Pharmaceuticals GmbH | And 5 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2013

The metabotropic glutamate receptor subtype 5 has evolved into a promising target for the treatment of various diseases of the central nervous system, such as Fragile X and l-DOPA induced dyskinesia. One of the most advanced clinical compound is Novartis' AFQ-056 (Mavoglurant), which served us as a template for a scaffold hopping approach, generating a structurally diverse set of potent analogs. Both the limited aqueous solubility and the relatively poor metabolic stability of AFQ-056 were improved with hexahydrocyclopenta[c]pyrrole derivative 54a, which proved to be a valuable candidate for further development. © 2013 Elsevier Ltd. All rights reserved.


You G.,Institute of Organic Synthesis | Cheng Z.,Institute of Organic Synthesis | Peng H.,Institute of Organic Synthesis | He H.,Institute of Organic Synthesis
Journal of Applied Polymer Science | Year: 2014

A novel, halogen-free, phosphorus-nitrogen containing flame retardant 2[4-(2,4,6-Tris{4-[(5,5-dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)hydroxymethyl]phenoxy}-(1,3,5)-triazine (TNTP) was successfully synthesized in a three-step process, and characterized by FTIR, NMR spectroscopy, mass spectra, and elemental analysis. A series of modified DGEBA epoxy resin with different loadings of TNTP were prepared and cured by 4,4-diaminodiphenylsulfone (DDS). Thermal gravimetric analysis and vertical burning test (UL-94) were used to evaluate the flame retardancy of TNTP on DGEBA epoxy resin. The results showed that TNTP had a great impact on flame retardancy. All modified thermosets by using TNTP exhibited higher Tg than pure DGEBA/DDS. The loading of TNTP at only 5.0 wt % could result in satisfied flame retardancy (UL-94, V-0) together with high char residue (27.3%) at 700°C. The addition of TNTP could dramatically enhance the flame retardancy of DGEBA epoxy resins, which was further confirmed by the analysis of the char residues by scanning electron microscopy and FTIR. Furthermore, no obviously negative effect was found on the Izod impact strength and flexural property of DGEBA epoxy resins when TNTP loading limited in 5.0 wt %. DGEBA/DDS containing 2.5 wt % TNTP could enhance Izod impact strength from 10.47 to 10.94 kJ m-2, and showed no appreciable effect on the flexural property (85.20 MPa) comparing with pure DGEBA/DDS (87.03 MPa). Results indicated that TNTP as a phosphorus-nitrogen synergistic intumescent flame retardant could be used for DGEBA epoxy resin. © 2014 Wiley Periodicals, Inc.


Ignatovich L.,Institute of Organic Synthesis | Romanovs V.,Institute of Organic Synthesis | Muravenko V.,Institute of Organic Synthesis | Sleiksha I.,Institute of Organic Synthesis | And 2 more authors.
Chemistry - A European Journal | Year: 2014

New highly cytotoxic 1-{3-[1-(5-organylsilyl-furan-2-yl)silinan-1-yl]propyl}amines and some trimethylgermyl analogues (IC50 1-7 μgmL-1) have been synthesized by a hydrosilylation reaction of aliphatic and heterocyclic N-allylamines in the presence of Speier's catalyst. The effects of the silacycle, the element-organic substituent in position 5 of the furan ring, and the structure of the amine on the cytotoxicity of the new compounds have been studied. Highly cytotoxic 1-{3-[1-(5-or-ganylsilylfuran-2-yl)silinan-1-yl]propyl}amines and some trimethylgermyl analogues (IC50 1-7 μgmL-1) have been synthesized by a hydrosilylation reaction of aliphatic and heterocyclic N-allylamines in the presence of Speier's catalyst. The effects of the silacycle, the element-organic substituent in position 5 of the furan ring, and the structure of the amine on the cytotoxicity of the new compounds have been studied. copy; 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Kulakov I.V.,Institute of Organic Synthesis | Turdybekov D.M.,Scientific Production Holding Phytochemistry
Chemistry of Heterocyclic Compounds | Year: 2010

Bicyclic pyrimido[2,1-b][1,3]thiazines were produced by the acylation of 4-aryl-substituted 3,4-di-hydropyrimidine(1H)-2-thiones with 3-bromopropionyl chloride, and their structures were proved by the data from X-ray crystallographic analysis. ©2010 Springer Science+Business Media, Inc.


Agelmenev M.E.,Institute of Organic Synthesis | Muldakhmetov Z.M.,Institute of Organic Synthesis | Bratukhin S.M.,Institute of Organic Synthesis | Polikarpov V.V.,Institute of Organic Synthesis
Molecular Crystals and Liquid Crystals | Year: 2011

In this work the results of the behavior modeling of several nematic liquid crystals layers located on the flat carbon substrate in the absence of boundary conditions are presented. Copyright © Taylor & Francis Group, LLC.

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